Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Alcohol Abuse and Addiction from Mice to Humans
Discussion Leader: Patricia Janak (Johns Hopkins University, USA)
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:25 pm
Michael Bruchas (University of Washington, USA)
"Decoding Neuromodulatory Circuits in Motivated Behaviors"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:40 pm
Introduction by Discussion Leader
8:40 pm - 9:20 pm
George Koob (National Institute on Alcohol Abuse and Alcoholism, NIH, USA)
"50 Years of Neuroscience Research at NIAAA: From Membranes to Microcircuits (Allosterism, Hyperkatifiea and Allostasis)"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Neuropeptide Signaling in Alcohol-Related Behaviors
Discussion Leader: Jeff Weiner (Wake Forest School of Medicine, USA)
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
Rajita Sinha (Yale University School of Medicine, USA)
"Alcohol Adaptations of Stress Circuits and Impact on Motivation, Intake and Relapse"
9:35 am - 9:45 am
Discussion
9:45 am - 10:05 am
Zoe McElligott (University of North Carolina at Chapel Hill, USA)
"CeA Neurotensinergic Neurons in Alcohol Consumption"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
Selected from Poster Abstracts: Stacey Robinson (University of North Carolina at Chapel Hill, USA)
"Central Amygdala Somatostatin Selectively Reduces Binge-Like Ethanol Intake"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Howard Becker (Medical University of South Carolina, USA)
"Role of Neuropeptides in Stress-Enhanced Alcohol Drinking and Relapse-Like Behavior"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Selected from Poster Abstracts: Daniel Bloodgood (Stanford University, USA)
"Central Amygdala Dynorphin/Kappa Opioid Regulation of Alcohol Drinking"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Olivier George (University of California, San Diego, USA)
"What's Driving Escalation of Alcohol Drinking? Evidence in Favor of the Crystallization Hypothesis"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Selected from Poster Abstracts: Samuel Centanni (Vanderbilt University, USA)
"An Insular-BNST Circuit Regulates Negative Affect Associated with Stress and Alcohol Abstinence"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizers: Veronica Alvarez (National Institute on Alcohol Abuse and Alcoholism, NIH, USA) and Rajita Sinha (Yale University School of Medicine, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Interoceptive Processing in Alcohol-Seeking
Discussion Leader: Andrew Holmes (National Institute on Alcohol Abuse and Alcoholism, NIH, USA)
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
Amy Lasek (University of Illinois at Chicago, USA)
"Contribution of Insular Extracellular Matrix to Compulsive Alcohol Drinking"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Andrey Ryabinin (Oregon Health and Science University, USA)
"Defining the Social in Models of Social Aspects of Alcohol Drinking and Dependence"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
Joyce Besheer (Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, USA)
"Interoceptive Effects of Low Dose Alcohol"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Selected from Poster Abstracts: Tiffany Wills (LSU Health Sciences Center New Orleans, USA)
"Effects of Adolescent Alcohol Exposure on Nociception and Amygdala Neurotransmission"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
The Role of Synaptic Plasticity in Making and Breaking Alcohol-Related Behaviors
Discussion Leader: Veronica Alvarez (National Institute on Alcohol Abuse and Alcoholism, NIH, USA)
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
Camin Dean (European Neuroscience Institute Göttingen, Germany)
"Molecular Mechanisms of Forgetting"
9:35 am - 9:45 am
Discussion
9:45 am - 10:05 am
Jun Wang (Texas A&M University Health Science Center, USA)
"Persistent Reduction of Alcohol-Drinking Behavior by Optogenetic Induction of Corticostriatal Synaptic Plasticity in the Dorsomedial Striatum"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
Selected from Poster Abstracts: Paula Zamudio-Bulcock (Medical University of South Carolina, USA)
"Knock-in Mice Expressing an Ethanol-Resistant GluN2A NMDA Receptor Subunit Show Altered Responses to Ethanol"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Brian Mathur (University of Maryland School of Medicine, USA)
"Dorsal Striatal Inhibitory Microcircuit Plasticity Underlying Compulsive Alcohol Drinking"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Roh-Yu Shen (University at Buffalo, SUNY, USA)
"Prenatal Ethanol Exposure Leads to Failure of Synaptic Maturation and Persistent Cognitive/Behavioral Deficits"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Brady Atwood (Indiana University School of Medicine, USA)
"Synaptic Fingerprints of Alcohol's Effects on Dorsal Striatal Glutamatergic Transmission"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Alcohol Use Disorders and Endocannabinoid Signaling
Discussion Leader: David Lovinger (National Institute on Alcohol Abuse and Alcoholism, NIH, USA)
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
Luis Natividad (The University of Texas at Austin, USA)
"Losing Balance: Dysregulated Endocannabinoid Signaling in Stress and Addiction"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Sachin Patel (Vanderbilt University, USA)
"Targeting Endocannabinoid Synthesis to Reduce Alcohol Consumption"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Selected from Poster Abstracts: Vijay Ramchandani (National Institute on Alcohol Abuse and Alcoholism, NIH, USA)
"Genetic Variants in the Endocannabinoid Pathway Are Associated with Sleep-Related Phenotypes in Alcohol Use Disorders"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Isabelle Boileau (Campbell Family Mental Health Research Institute, Canada)
"Brain Imaging of Endocannabinoid Metabolism in Alcohol Use Disorder: PET Studies of the FAAH Probe [11-C]CURB"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Monitoring and Modulating the Brain: New Tools Focusing on Catecholamines
Discussion Leader: Rueben Gonzales (University of Texas at Austin, USA)
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:25 am
Cody Siciliano (Vanderbilt University School of Medicine, USA)
"A Cortical-Brainstem Circuit Predicts and Governs Compulsive Alcohol Drinking"
9:25 am - 9:30 am
Discussion
9:30 am - 9:50 am
Kay Tye (Salk Institute for Biological Studies, USA)
"Computational Approaches to Visualizing Cortical Activity States in Alcohol Drinking"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
Patricia Jensen (National Institute of Environmental Health Sciences, NIH, USA)
"Developmental Disruption of Locus Coeruleus-Norepinephrine Signaling Results in Phenotypes Relevant to Neurodevelopmental Disorders"
10:50 am - 11:00 am
Discussion
11:00 am - 11:20 am
Santiago Canals (Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas, Spain)
"Preclinical and Clinical Evidence of Progressive Microstructural Damage, Altered Extracellular Space, and Dopamine Diffusion in Early Abstinence"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Erin Calipari (Vanderbilt University, USA)
"A Novel Computational Framework for the Role of Dopamine in Learning and Memory"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Karla Kaun (Brown University, USA)
"To Drink or Not(ch) to Drink: Molecular Mechanisms Through Which Alcohol Influences Memory in Drosophila "
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Stress-Alcohol Interactions in the Control of Behavior
Discussion Leader: John Woodward (Medical University of South Carolina, USA)
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
Katherine Holleran (Wake Forest Baptist Health, USA)
"Interactions of Stress and Alcohol Exposure in Kappa Opioid Receptor Mediated Anxiety-Like Behavior and Dopamine Dynamics in the Nucleus Accumbens"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Verginia Cuzon Carlson (Oregon Health and Science University, USA)
"Synaptic Changes Within the Rhesus Putamen that May Underlie a Bias Towards Sensory-Motor Action Patterns: Potential Role of Glucocorticoid Receptors"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Selected from Poster Abstracts: Junghyup Suh (McLean Hospital / Harvard Medical School, USA)
"Functional Dissection of Basolateral Amygdala Neural Circuits for Alcohol Seeking Behaviors"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Robert Messing (The University of Texas at Austin, USA)
"Identifying Functional Roles for Specific Neuropeptides and GABA Expressed in CRF Neurons of the Central Amygdala"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Cortical Function and Dysfunction in Compulsive Alcohol Seeking
Discussion Leader: Heather Richardson (University of Massachusetts Amherst, USA)
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
Nadia Chaudhri (Concordia University, Canada)
"Manipulating Corticostriatal Circuits to Curtail Reward-Related Behaviour"
9:35 am - 9:45 am
Discussion
9:45 am - 9:55 am
Selected from Poster Abstracts: Christopher Lapish (Indiana University - Purdue University Indianapolis, USA)
"Neural Encoding in Medial Prefrontal Cortex During Aversion Resistant Drinking in Rodent Models of Alcohol Use Disorder"
9:55 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
Judson Chandler (Medical University of South Carolina, USA)
"Adolescent Alcohol Exposure Enhances Perineuronal Nets in the Medial Prefrontal Cortex and Impairs Fear Extinction Learning in Adulthood"
10:50 am - 11:00 am
Discussion
11:00 am - 11:20 am
Colleen Hanlon (Wake Forest School of Medicine, USA)
"Oops... I Did It Again: Promising Cortical Targets for Decreasing Risky Drinking and Relapse with Transcranial Magnetic Stimulation"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Selected from Poster Abstracts: Jennifer Rinker (Medical University of South Carolina, USA)
"Differential Engagement of the Dorsomedial Prefrontal Cortex and the Mediodorsal Thalamus During Alcohol Consumption"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Dorit Ron (University of California, San Francisco, USA)
"mTORC1 in the Orbitofrontal Cortex Contributes to Alcohol Seeking and Habit"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Selected from Poster Abstracts: Sema Quadir (Boston University School of Medicine, USA)
"Involvement of Fronto-Cortical Sigma-1 Receptors in Alcohol-Induced Hyperalgesia"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cellular Signals Controlling Alcohol Intake
Discussion Leader: Paul Slesinger (Icahn School of Medicine at Mount Sinai, USA)
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
Kazue Hashimoto-Torii (Children's National Medical Center, USA)
"Live Cell-Seq: A New Tool for Alcohol Study"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Selected from Poster Abstracts: Kimberly Nixon (The University of Texas at Austin, USA)
"Alcohol Alters Exosome Content: Implications for the Neuroimmune Actions of Alcohol"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Brian McCool (Wake Forest School of Medicine, USA)
"Ethanol Modulation of Glutamate Presynaptic Function: Mechanisms and Consequences"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Kim Raab-Graham (Wake Forest School of Medicine, USA)
"Under the Influence: How Ethanol Hijacks RNA-Binding Proteins to Change the Synaptic Landscape"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure