Saturday
2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Sex Differences in Alcohol Research
Discussion Leader: Barbara Juarez (University of Washington, USA)
3:45 pm - 3:50 pm
Introduction by Discussion Leader
3:50 pm - 4:05 pm
Megan Bertholomey (University of Pittsburgh, USA)
"Sex Differences in Alcohol-Motivated Behavior: Role of Stress, Circulating Gonadal Hormones, and Glutamate Systems"
4:05 pm - 4:10 pm
Discussion
4:10 pm - 4:25 pm
Daniel Popoola (Research Institute on Addictions, University at Buffalo, USA)
"Maternal and Paternal Lineage Contributions to Transgenerational Effects of Prenatal Alcohol Exposure"
4:25 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Molecular Signatures of Alcohol Abuse
Discussion Leader: Jennifer Rinker (Medical University of South Carolina, USA)
7:30 pm - 7:45 pm
William Giardino (Stanford University, USA)
"CRISPR-Cas9 Editing of Hypocretin (Orexin) Receptor Genes in Cell Type-Specific Extended Amygdala Neurons Modulating Alcohol Drinking and Anxiety-Related Behavior "
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
Laverne Melon (Tufts University School of Medicine, USA)
"d-GABAA Receptor Mediated Tonic Inhibition on Parvalbumin Interneurons Is Critical Target for Binge Drinking and Alcohol-Associated Anxiety"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Sadie Nennig (University of Georgia, USA)
"Selective Lesioning of Nuclear Factor-kB Activated Cells in the Nucleus Accumbens Shell Attenuates Alcohol Place Preference"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Daniel da Silva e Silva (National Institute on Alcohol Abuse and Alcoholism, NIH, USA)
"The Role of LRRK2, a Parkinson's Disease-Related Protein, in Regulating Striatal Function and Alcohol Drinking in Mice"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Alexey Ostroumov (University of Pennsylvania, USA)
"Stress, Nicotine, and Drugs of Abuse Converge onto the GABAergic Circuitry of the VTA and Increase Ethanol Self-Administration"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Deborah Luessen (Wake Forest School of Medicine, USA)
"Acute Ethanol Exposure Enhances Ubiquitination and Degradation of β-Arrestin in Rat Prefrontal Cortex and Neuroblastoma N2A Cells"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Brainwide Circuits Defining Drinking
Discussion Leader: Karina Abrahao (National Institutes of Health, USA)
9:00 am - 9:15 am
Florence Varodayan (The Scripps Research Institute, USA)
"Alcohol-Induced Neuroadaptation of IL-1 Signaling at GABAergic Synapses in the Mouse Prelimbic Cortex"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Stacey Robinson (University of North Carolina at Chapel Hill, USA)
"The Role of Cortical Neuropeptides in Binge-Like Consumption of Ethanol"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Elizabeth Avegno (LSU Health Sciences Center New Orleans, USA)
"CeA Projections to PAG Mediate Alcohol Dependence-Induced Hyperalgesia in Rats"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Sarah Ewin (Wake Forest School of Medicine, USA)
"The Role of the Basolateral Amygdala-Nucleus Accumbens Circuitry in Alcohol Addiction Vulnerability"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Milan Valyear (Concordia University, Canada)
"Distinct Striatal Targets for Midbrain Dopamine Neurons that Support Alcohol-Seeking Elicited by Discrete and Contextual Environmental Cues"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
Mehdi Farokhnia (National Institute on Alcohol Abuse and Alcoholism, NIH, USA)
"Disentangling the Effects of Exogenous Ghrelin Administration in Relation to Alcohol Versus Food Reward Anticipation in Alcohol-Dependent Individuals: A Brain fMRI Study"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Grantsmanship
Discussion Leader: Anushree Karkhanis (Wake Forest School of Medicine, USA)
1:30 pm - 2:30 pm
Panel Discussion
NIH Fellowships and Early Career Development Grants
Changhai Cui (National Institute on Alcohol Abuse and Alcoholism, NIH, USA)
Antonio Noronha (National Institute on Alcohol Abuse and Alcoholism, NIH, USA)
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes
