Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Novel Mechanisms of Multiple-Organ and Tissue Injury
Discussion Leader: Jan Hoek (Thomas Jefferson University, USA)
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:25 pm
Bernd Schnabl (University of California, San Diego, USA)
"Host-Microbiome Interactions in Alcohol-Associated Diseases"
8:25 pm - 8:40 pm
Discussion
8:40 pm - 9:15 pm
Gyongyi Szabo (University of Massachusetts Medical School, USA)
"Triggers, Pathways and Mediators of Alcohol-Induced Tissue Inflammation"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Proteostasis (Protein Homeostasis) in Alcohol-Induced Organ Injury
Discussion Leader: Bin Gao (National Institutes of Health, USA)
9:00 am - 9:20 am
Wen-Xing Ding (University of Kansas Medical Center, USA)
"Autophagy, a Common Mechanism for Alcohol-Induced Liver and Pancreatic Injury"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Stephen Pandol (Cedars-Sinai Medical Center, USA)
"Regulation of Endoplasmic Reticulum Protein Processing with Alcohol"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Selected from Poster Abstracts: William Balch (The Scripps Research Institute, USA)
"Precision Monitoring of Alcohol in Health and Disease"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Selected from Poster Abstracts: Shengmin Yan (Indiana University School of Medicine, USA)
"Establishment of a Cellular Model to Study Ethanol-Induced Lipophagy"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Pranoti Mandrekar (University of Massachusetts Medical School, USA)
"Targeting Proteostasis Pathways: New Therapeutic Paradigm in Alcoholic Liver Disease"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Srinivasan Dasarathy (Cleveland Clinic, USA)
"Mechanism of Skeletal Muscle Proteostasis and Sarcopenia in Alcoholic Liver Disease"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Selected from Poster Abstracts: Mengwei Zang (University of Texas Health Science Center at San Antonio, USA)
"Activation of mTORC1 Contributes to the Development of Alcoholic Liver Injury in Mice"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Selected from Poster Abstracts: Hyo-Jung Kwon (College of Veterinary Medicine, Chungnam National University, South Korea)
"Vitamin D3 Upregulated Protein 1-Depdendant Autophagy and Fatty Acid Oxidation Attenuates Liver Steatosis"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Elizabeth Kovacs (University of Colorado Denver, USA) and Pranoti Mandrekar (University of Massachusetts Medical School, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Alcohol, Stem Cells, and Cancer
Discussion Leader: Helmut Seitz (University of Heidelberg, Germany)
7:30 pm - 7:50 pm
Lorraine Gudas (Weill Cornell Medicine, USA)
"The Effects of Alcohol on Epithelial Stem Cells of the Oral Cavity and Esophagus During Carcinogenesis"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Vasilis Vasiliou (Yale School of Public Health, USA)
"Aldehyde Dehydrogenases in Cancer Stem Cells"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Keigo Machida (Keck School of Medicine, University of Southern California, USA)
"Cell Fate Decision and Metabolic Reprograming of Tumor-Initiating Stem-Like Cells in Alcohol-Associated Injury and Cancer"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Selected from Poster Abstracts: Chin-Yo Lin (University of Houston, USA)
"Alcohol Modulates Hormonal and Oncogenic Signaling in Breast Cancer Cells"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Selected from Poster Abstracts: Prasanna Chandramouleeswaran (The University of Pennsylvania, USA)
"Alcohol Promotes Esophageal Tumor Growth by Enriching Cancer Stem Cells with a High Autophagy Capacity"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Immunologic Mechanisms
Discussion Leader: Gavin Arteel (University of Louisville, USA)
9:00 am - 9:20 am
Cynthia Ju (University of Colorado Health Science Center, USA)
"IL-1 Receptor Like 1 (ST2) Protects Against Alcoholic Liver Injury and Inflammation"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Hidekazu Tsukamoto (University of Southern California, USA)
"Caspase 11-Gasdermin-D Pathway in Alcoholic Hepatitis"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Selected from Poster Abstracts: Thomas McIntyre (Cleveland Clinic, USA)
"Molecular Mechanisms of Alcoholic Kidney Disease: Role of Neutrophils"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Selected from Poster Abstracts: Kyle Poulsen (Cleveland Clinic, USA)
"MIF Inhibition Protects Hepatocytes from Ethanol-Induced Injury Independent of Neutrophil Accumulation"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Flavia Souza-Smith (LSU Health Sciences Center New Orleans, USA)
"Mesenteric Lymphatic/Perilymphatic Adipose Tissue Crosstalk: Mechanism of Alcohol Immunomodulation"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Elizabeth Kovacs (University of Colorado Denver, USA)
"Alcohol Intoxication and the Pulmonary Inflammatory Response After Injury"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Selected from Poster Abstracts: Yingzi Yang (Harvard School of Dental Medicine, USA)
"Hippo Signaling in Alcohol-Induced Multiple Organ Injury and Inflammation"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Selected from Poster Abstracts: Puneet Puri (Virginia Commonwealth University, USA)
"Circulating Microbiome Changes Are Associated with the Development and Severity of Alcoholic Hepatitis"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Non-Coding RNA and Extracellular Vesicles
Discussion Leader: David Brigstock (Nationwide Children's Hospital, USA)
7:30 pm - 7:50 pm
Vijay Shah (Mayo Clinic, USA)
"Extracellular Vesicles and Alcoholic Liver Disease"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Li Wang (University of Connecticut, USA)
"Non-Coding RNA as Novel Regulator of Alcoholic Fatty Liver"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Won-Il Jeong (KAIST, South Korea)
"Exosomes and TLR3 in Liver Fibrosis"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Selected from Poster Abstracts: Kelly McDaniel (Baylor Scott and White Health, USA)
"The Let7/Lin28 Axis Regulates Activation of Hepatic Stellate Cells in Alcoholic Liver Injury"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Selected from Poster Abstracts: Ming-Jiang Xu (National Institute on Alcohol Abuse and Alcoholism, NIH, USA)
"ER Stress-Dependent Release of Mitochondrial DNA Enriched Microparticles Contributes to Acute-on-Chronic Alcoholic Neutrophilia and Hepatotoxicity"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Alcohol, Gut Microbiota, Intestinal Barrier Function, and Fat Metabolism
Discussion Leader: Carol Casey (University of Nebraska, USA)
9:00 am - 9:20 am
Craig McClain (University of Louisville, USA)
"Alcohol:Fat Interactions in the Development/Treatment of Alcoholic Liver Disease"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Min You (Northeast Ohio Medical University, USA)
"Adiponectin-FGF15/19 Signaling, a Pivotal Adipose-Gut-Liver Axis in Alcoholic Steatohepatitis"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Selected from Poster Abstracts: Richard Parker (Leeds Liver Unit, St James's University Hospital, United Kingdom)
"The Impact of Adiosity on Alcoholic Hepatitis: Just Enough Fat Is Good for You"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Selected from Poster Abstracts: Rotonya Carr (University of Pennsylvania, USA)
"Absence of Perilipin 2 Prevents the Increase of Long-Chain Ceramides in the Lipid Droplet Fractions of Alcohol-Fed Mice"
10:25 am - 10:30 am
Discussion
10:30 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
Ali Keshavarzian (Rush University Medical Center, USA)
"Microbiota, Gut Leakiness to Endotoxins and Circadian Disruption in Alcohol Use Disorders"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
Patricia Molina (Louisiana State University, USA)
"Alcohol-SIV/HIV-ART Interactions Promote Metabolic Dysregulation"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Selected from Poster Abstracts: Robert Helsley (Cleveland Clinic Foundation, USA)
"Targeting the Gut Microbial TMA-Lyase for the Treatment of Alcohol-Induced Liver Injury"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Selected from Poster Abstracts: Tasha Barr (University of California, Riverside, USA)
"Impact of Chronic Ethanol Consumption on Pathophysiology and Mucosal Gene Expression of the Gastrointerestinal Tract in Rhesus Macaques"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
George Koob (National Institute on Alcohol Abuse and Alcoholism, NIH, USA)
"Alcohol-Induced Organ Injury: Current and Future NIAAA Priorities"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Mitochondria in Alcohol-Induced Organ Damage
Discussion Leader: John Lemasters (Medical University of South Carolina, USA)
7:30 pm - 7:50 pm
Gyorgy Hajnoczky (Thomas Jefferson University, USA)
"Targeting of Mitochondrial Dynamics and Survival Mechanisms by Alcohol in Heart and Liver"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Shannon Bailey (University of Alabama at Birmingham, USA)
"Role of the Circadian Clock in Alcohol-Induced Alterations in Hepatic Mitochondrial Energy Metabolism"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Narayan Avadhani (University of Pennsylvania, USA)
"Mitochondria-Targeted Cyp2E1 Modulates Alcohol Liver Toxicity"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Selected from Poster Abstracts: Elizabeth Bartolak-Suki (Boston University, USA)
"Beneficial and Harmful Level of Alcohol Interact with Mechanical Stretch Pattern on Mitochondrial Function in Vascular Smooth Muscle Cells"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Selected from Poster Abstracts: Hongkyun Kim (Rosalind Franklin University of Medicine and Science, USA)
"Alcohol-Induced Muscle Damage in C. elegans "
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Preclinical/Translational Approaches and Treatment in Alcohol-Associated Diseases
Discussion Leader: Mack Mitchell (University of Texas Southwestern Medical Center, USA)
9:00 am - 9:20 am
Philippe Mathurin (Centre Hospitalier Universitaire de Lille, France)
"Therapeutic Strategy in Severe Alcoholic Hepatitis: From Present to Future Development of New Molecules"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Ramon Bataller (University of Pittsburgh, USA)
"Novel Therapeutic Targets for Alcoholic Hepatitis"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Selected from Poster Abstracts: Devanshi Seth (Centenary Institute, Royal Prince Alfred Hospital, Australia)
"Performance of Liver Function Tests in the GenomALC Chohor for Alcohol Consumption: New Gender Cutoffs in Alcoholics with Liver Cirrhosis"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Selected from Poster Abstracts: Ashwani Singal (University of Alabama at Birmingham, USA)
"Cellular Biogenergetics: Personalizing Treatment in Alcoholic Liver Disease"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
George Kunos (National Institutes of Health, USA)
"Multitarget Approach for the Pharmacotherapy of Liver Fibrosis"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Shelly Lu (Cedars-Sinai Medical Center, USA)
"Role of SAMe in Liver Injury and Cancer"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Urszula Iwaniec (Center for Healthy Aging Research, Oregon State University, USA)
"Alcohol: A Simple Nutrient with Complex Actions on Bone in the Adult Skeleton"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Post-Metabolic Signaling and Stress Pathways
Discussion Leader: Charles Lang (Penn State College of Medicine, USA)
7:30 pm - 7:50 pm
Pal Pacher (National Institute on Alcohol Abuse and Alcoholism, NIH, USA)
"Deleterious Effects of Binge Drinking on Chronic Ethanol Feeding-Induced Metabolic Dysregulation and Cardiovascular Dysfunction in Mice"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Jason Gardner (LSU Health Sciences Center New Orleans, USA)
"Alcohol and The Heart: Interference of Compensatory Remodeling"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Daria Mochly-Rosen (Stanford University School of Medicine, USA)
"Ethanol and Precision Medicine: New Considerations for an Old Problem"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Selected from Poster Abstracts: Mariann Piano (University of Illinois at Chicago College of Nursing, USA)
"MicroRNA21 Inhibtion Restores Binge Drinking Impaired Microvascular Function in Young Adults"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Selected from Poster Abstracts: Manikandan Panchatcharam (LSU Health Sciences Center Shreveport, USA)
"Alcohol-Induced LPP3 Suppression Leads to Blood-Brain Barrier Dysfunction"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure