Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Novel Mechanisms of Multiple-Organ and Tissue Injury
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:25 pm
"Host-Microbiome Interactions in Alcohol-Associated Diseases"
8:25 pm - 8:40 pm
Discussion
8:40 pm - 9:15 pm
"Triggers, Pathways and Mediators of Alcohol-Induced Tissue Inflammation"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Proteostasis (Protein Homeostasis) in Alcohol-Induced Organ Injury
9:00 am - 9:20 am
"Autophagy, a Common Mechanism for Alcohol-Induced Liver and Pancreatic Injury"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Regulation of Endoplasmic Reticulum Protein Processing with Alcohol"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Precision Monitoring of Alcohol in Health and Disease"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Establishment of a Cellular Model to Study Ethanol-Induced Lipophagy"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Targeting Proteostasis Pathways: New Therapeutic Paradigm in Alcoholic Liver Disease"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Mechanism of Skeletal Muscle Proteostasis and Sarcopenia in Alcoholic Liver Disease"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Activation of mTORC1 Contributes to the Development of Alcoholic Liver Injury in Mice"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Vitamin D3 Upregulated Protein 1-Depdendant Autophagy and Fatty Acid Oxidation Attenuates Liver Steatosis"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Alcohol, Stem Cells, and Cancer
7:30 pm - 7:50 pm
"The Effects of Alcohol on Epithelial Stem Cells of the Oral Cavity and Esophagus During Carcinogenesis"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Aldehyde Dehydrogenases in Cancer Stem Cells"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Cell Fate Decision and Metabolic Reprograming of Tumor-Initiating Stem-Like Cells in Alcohol-Associated Injury and Cancer"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Alcohol Modulates Hormonal and Oncogenic Signaling in Breast Cancer Cells"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Alcohol Promotes Esophageal Tumor Growth by Enriching Cancer Stem Cells with a High Autophagy Capacity"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:20 am
"IL-1 Receptor Like 1 (ST2) Protects Against Alcoholic Liver Injury and Inflammation"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Caspase 11-Gasdermin-D Pathway in Alcoholic Hepatitis"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Molecular Mechanisms of Alcoholic Kidney Disease: Role of Neutrophils"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"MIF Inhibition Protects Hepatocytes from Ethanol-Induced Injury Independent of Neutrophil Accumulation"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Mesenteric Lymphatic/Perilymphatic Adipose Tissue Crosstalk: Mechanism of Alcohol Immunomodulation"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Alcohol Intoxication and the Pulmonary Inflammatory Response After Injury"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Hippo Signaling in Alcohol-Induced Multiple Organ Injury and Inflammation"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Circulating Microbiome Changes Are Associated with the Development and Severity of Alcoholic Hepatitis"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Non-Coding RNA and Extracellular Vesicles
7:30 pm - 7:50 pm
"Extracellular Vesicles and Alcoholic Liver Disease"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Non-Coding RNA as Novel Regulator of Alcoholic Fatty Liver"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Exosomes and TLR3 in Liver Fibrosis"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"The Let7/Lin28 Axis Regulates Activation of Hepatic Stellate Cells in Alcoholic Liver Injury"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"ER Stress-Dependent Release of Mitochondrial DNA Enriched Microparticles Contributes to Acute-on-Chronic Alcoholic Neutrophilia and Hepatotoxicity"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Alcohol, Gut Microbiota, Intestinal Barrier Function, and Fat Metabolism
9:00 am - 9:20 am
"Alcohol:Fat Interactions in the Development/Treatment of Alcoholic Liver Disease"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Adiponectin-FGF15/19 Signaling, a Pivotal Adipose-Gut-Liver Axis in Alcoholic Steatohepatitis"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"The Impact of Adiosity on Alcoholic Hepatitis: Just Enough Fat Is Good for You"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Absence of Perilipin 2 Prevents the Increase of Long-Chain Ceramides in the Lipid Droplet Fractions of Alcohol-Fed Mice"
10:25 am - 10:30 am
Discussion
10:30 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"Microbiota, Gut Leakiness to Endotoxins and Circadian Disruption in Alcohol Use Disorders"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
"Alcohol-SIV/HIV-ART Interactions Promote Metabolic Dysregulation"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Targeting the Gut Microbial TMA-Lyase for the Treatment of Alcohol-Induced Liver Injury"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Impact of Chronic Ethanol Consumption on Pathophysiology and Mucosal Gene Expression of the Gastrointerestinal Tract in Rhesus Macaques"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Alcohol-Induced Organ Injury: Current and Future NIAAA Priorities"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Mitochondria in Alcohol-Induced Organ Damage
7:30 pm - 7:50 pm
"Targeting of Mitochondrial Dynamics and Survival Mechanisms by Alcohol in Heart and Liver"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Role of the Circadian Clock in Alcohol-Induced Alterations in Hepatic Mitochondrial Energy Metabolism"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Mitochondria-Targeted Cyp2E1 Modulates Alcohol Liver Toxicity"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Beneficial and Harmful Level of Alcohol Interact with Mechanical Stretch Pattern on Mitochondrial Function in Vascular Smooth Muscle Cells"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Alcohol-Induced Muscle Damage in C. elegans "
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Preclinical/Translational Approaches and Treatment in Alcohol-Associated Diseases
9:00 am - 9:20 am
"Therapeutic Strategy in Severe Alcoholic Hepatitis: From Present to Future Development of New Molecules"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Novel Therapeutic Targets for Alcoholic Hepatitis"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Performance of Liver Function Tests in the GenomALC Chohor for Alcohol Consumption: New Gender Cutoffs in Alcoholics with Liver Cirrhosis"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Cellular Biogenergetics: Personalizing Treatment in Alcoholic Liver Disease"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Multitarget Approach for the Pharmacotherapy of Liver Fibrosis"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Role of SAMe in Liver Injury and Cancer"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Alcohol: A Simple Nutrient with Complex Actions on Bone in the Adult Skeleton"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Post-Metabolic Signaling and Stress Pathways
7:30 pm - 7:50 pm
"Deleterious Effects of Binge Drinking on Chronic Ethanol Feeding-Induced Metabolic Dysregulation and Cardiovascular Dysfunction in Mice"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Alcohol and The Heart: Interference of Compensatory Remodeling"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Ethanol and Precision Medicine: New Considerations for an Old Problem"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"MicroRNA21 Inhibtion Restores Binge Drinking Impaired Microvascular Function in Young Adults"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Alcohol-Induced LPP3 Suppression Leads to Blood-Brain Barrier Dysfunction"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure