Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Molecular and Cellular Mechanisms of Fibrosis
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:25 pm
"The Complex Role of the ECM in Liver Fibrosis"
8:25 pm - 8:40 pm
Discussion
8:40 pm - 9:15 pm
"Circadian Rhythms and the Muscle Molecular Clock: Why Muscles Need to Keep Time"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Protein and Organelle Homeostasis: Novel Mechanisms of Alcohol-Induced Organ Injury
9:00 am - 9:20 am
"Regulation of Inflammatory Liver Injury by Autophagy"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Role of SNARE Proteins in Dysregulated Autophagy in Alcoholic Pancreatitis"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Ethanol-Based Perturbation of Lipid Droplet Catabolism in Hepatocytes"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Pyroptosis in Alcoholic Liver Disease"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Mitochondrial Depolarization and Disregulated Mitophagy Occur in both Alcoholic and Non-Alcoholic Fatty Liver Disease"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
" Critical Role of TFEB-Mediated Lysosomal Biogenesis in Alcohol-Induced Pancreatitis in Mice and Humans"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Hepatic Ceramide Reduction Alleviates Alcoholic Steatosis and Insulin Resistance in Female Mice"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Impaired Autophagy Flux in Alcoholic Liver Disease: A Link Between miR155, Impaired Autophagosome Function and Exosome Production"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:50 pm
"Small Molecule Inhibition of Gut Microbial Choline Metabolism as a Therapeutic Strategy in Alcoholic Liver Disease"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Microbiota and Gut Barrier in Alcoholic Liver Disease"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"Alcohol Consumption Alters sIgA-Binding of Intestinal Microbes"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Gut Microbial Metabolite, Urolithin A Mitigates ALD by Enhancing Gut Barrier Integrity and Blocking Inflammation"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Deletion of TRPV6 Channel Attenuates Alcohol and Stress-Induced Gut Barrier Dysfunction, Endotoxemia and Liver Damage"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Intestinal Stem Cell Proliferation and Differentiation in Alcoholic Liver Disease"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Alcohol and Cell-Cell Communications: From Extracellular Vesicles to Cyto-, Chemo- and Adipokines
9:00 am - 9:20 am
"Secretin Modulation of Biliary Senescence in Alcohol-Induced Liver Damage"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Extracellular Vesicle-Mediated Activation of Kupffer Cells in ALD"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"HMGB-1: DAMP Extroardinare"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Regulation of Alcohol and Sweet Preference by the Hormone FGF21"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Kupffer Cells Undergo Anti-Inflammatory Changes in Response to Short-Term Alcohol Exposure"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Hepatocyte- and Myeloid-Derived Macrophage Migration Inhibitory Factor Contribute to Steatosis and ER Stress in Models of Ethanol Feeding in Mice"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Intestinal miRNA Release by Phosphorylation of RNA-Binding Protein AUF1"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"A New Mechanism of Liver Sinusoidal Endothelial Cell (LSEC) Dysfunction in Alcoholic Liver Disease: The Role of Cytochrome P450 E1 (CYP2E1) and HSP90 Acetylation"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Big Data and Bioinformatics: Emerging Insights from Omics
7:30 pm - 7:50 pm
"Integrated 'Omics' Approach for Biomarker Discovery in Alcoholic Hepatitis"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Application of Protein Arrays in Studying Severe Alcoholic Hepatitis and Beyond"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"miRNA Regulation of PBMCs in Alcoholic Hepatitis"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Clinical Risk Factors for Alcoholic Cirrhosis in a Large Cohort of Heavy Drinkers"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Genetic Factors, Post-Metabolic Signaling and Stress Pathways
9:00 am - 9:20 am
"Acetaldehyde Dehydrogenase 2 Deficiency, Alcoholic LIver Disease and Cancer"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Lipins in Regulating Lipid Metabolism"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Human Genetic Studies Reveal Heterogenous Causes of Fatty Liver Disease"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Endocannabinoid-CB1-R Signaling Contributes to the Acute Cardiovascular Effects of Alcohol: Role of Gut-Liver-Heart Connection"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"The Epigenetic Regulator SIRT6 Protects the Liver from the Alcohol-Induced Tissue Injury via Control of Oxidative Stress"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Impact of Chronic Alcohol and Hepatocyte Circadian Clock Disruption on Diurnal Rhythms of Lipid Droplet-Associated Genes and Hepatic Steatosis in Mice"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"The Hippo Kinase Mst1 Protects Alcoholic Induced Liver Damage by Inhibiting Inflammation"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Dysregulated Adult Splicing Program in Hepatocytes Leads to Severe Alcoholic Hepatitis"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Mitochondrial Dynamics, Dysfunction and Adaptation
7:30 pm - 7:50 pm
"Crosstalk of Microbiota and Host Mitochondria in Metabolic and Longevity Regulation"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Mitochondrial Dysfunction in Skeletal Muscle"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Mitochondrial Dynamics and Turnover in Liver Disease"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Disruption of Mitochondrial Dynamics Accelerate Alcohol-Induced Liver Injury in Mouse by Regulating Mitophagy"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Alcohol-Induced Mitochondrial Derangements in the Alveolar Macrophage"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Translational and Clinical Approaches for Treatment of Alcohol-Induced Tissue Injury
9:00 am - 9:20 am
"Controversies in Clinical Trials in ALD"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Cardiovascular Risk Associated with Binge Drinking in Young Adults"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Interactions Between Alcohol Consumption and Metabolic Syndrome in the General Population"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Clinical Trials for Alcoholic Hepatitis: Anakinra"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Alcohol-Associated Alterations in Lung Immunity"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Severity of Human Alcoholic Liver Disease Is Associated with Reduced NAD+ Content"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Immune Checkpoint Axes Are Dysregulated in Patients with Alcoholic Hepatitis"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Systemic Effects of Alcohol: Cross-Talk Between Multiple Organs
7:30 pm - 7:50 pm
"Alcohol, Aging and HIV: Dissecting Mechanisms Driving Enhanced Comorbidities"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Lung-Liver Interactions in Alcoholic Liver Disease"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"Adipocyte Apoptosis Enhances Hepatic Fat Accumulation and Liver Injury in the Experimental Models of Alcoholic and Nonalcoholic Steatohepatitis"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Adipose FGFR1 Regulates Binge Alcohol-Induced Adipolipolysis and Hepatic Fat Accumulation in Mice"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Stress Signaling: New Mechanisms of Alcohol-Evoked Cardiac Arrhythmias"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Chronic Alcohol-Induced Neuroinflammation Involves CCR2/5-Dependent Peripheral Macrophage Infiltration and Altered Synaptic Maturation"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure