Saturday
2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Keynote Session: Alternative Models for Alcohol-Related Research
Our speakers in this session will challenge convention by using novel methods and approaches in alcohol research.
Discussion Leaders: Xiaohui Wang (Harvard School of Dental Medicine, USA) and Sloan Lewis (University of California, Irvine, USA)
3:45 pm - 4:10 pm
Charles Lovely (University of Louisville, USA)
"Using Zebrafish to Model Gene-Ethanol Interactions and Their Impact on Craniofacial Development"
4:10 pm - 4:15 pm
Discussion
4:15 pm - 4:25 pm
Liya Pi (University of Florida, USA)
"CTGF Regulation During Liver Regeneration: Involving Yap Activity that Is Antagonized by HNF4a and Required for Ethanol-Detoxification"
4:25 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Pathophysiology of Alcohol-Related Organ Damage
Mechanisms of disease progression in multiple organs will be discussed in this session related to alcohol-induced end organ damage.
Discussion Leaders: Kyle Poulsen (Cleveland Clinic, USA) and Carlos Sanz Garcia (Cleveland Clinic Foundation, USA)
7:30 pm - 7:50 pm
Anil Noronha Antony (Thomas Jefferson University, USA)
"Impact of Chronic Alcohol Consumption on Mitochondrial Physiology in Aging Rats"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:15 pm
Jennifer Valcin (University of Alabama at Birmingham, USA)
"Impact of Chronic Alcohol and Hepatocyte Circadian Clock Disruption on Diurnal Rhythms of Lipid Droplet-Associated Genes and Hepatic Steatosis"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
Hui Qian (University of Kansas Medical Center, USA)
"Role of P62 in Chronic-Plus-Binge Alcohol-Induced Hepatic Protein Aggregates and Stress Granules"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
Jason Correnti (Perelman School of Medicine, University of Pennsylvania, USA)
"Hepatic Ceramide Reduction Alleviates Alcoholic Steatosis and Insulin Resistance in Female Mice"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Seung-Jin Kim (National Institute on Alcohol Abuse and Alcoholism, NIH, USA)
"Adipocyte Death Contributes to Alcoholic Liver Injury"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Translational/Therapeutic Developments in Alcohol-Induced Tissue Injury
This session will connect "bench to bedside" concepts in alcohol-related diseases.
Discussion Leader: Danielle Levitt-Budnar (LSU Health Sciences Center New Orleans, USA)
9:00 am - 9:25 am
Vijay Shah (Mayo Clinic, USA)
"Translational Studies in Alcoholic Hepatitis"
9:25 am - 9:30 am
Discussion
9:30 am - 9:55 am
Adam Kim (Cleveland Clinic, USA)
"miRNA Regulation of PBMCs in Alcoholic Hepatitis"
9:55 am - 10:00 am
Discussion
10:00 am - 10:25 am
Jing Ma (National Institute on Alcohol Abuse and Alcoholism, NIH, USA)
"Immunohistochemistry Analyses of Inflammatory Cells and Signaling Pathways in Severe Alcoholic Hepatitis"
10:25 am - 10:30 am
Discussion
10:30 am - 10:55 am
Shaogui Wang (University of Kansas Medical Center, USA)
"Critical Role of TFEB-Mediated Lysosomal Biogenesis in Alcohol-Induced Pancreatitis in Mice and Humans"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: What Can You Learn from Successful Scientists?
This session will adopt a "speed mentoring" format with Drs Arteel, Bailey, Pritchard and Li, allowing trainees to interactively discuss a wide range of topics related to mentor/mentee relationships (communication), self-motivation, overcoming scientific hurdles/funding issues, funding mechanisms for trainees, work-life balance and mental health.
Discussion Leaders: Holly Hulsebus (University of Colorado, USA) and Anil Noronha Antony (Thomas Jefferson University, USA)
1:30 pm - 2:30 pm
Panel Discussion
Interactive Focus Groups
Gavin Arteel (University of Pittsburgh, USA)
Shannon Bailey (University of Alabama at Birmingham, USA)
Li Lin (National Institute on Alcohol Abuse and Alcoholism, NIH, USA)
Michele Pritchard (University of Kansas Medical Center, USA)
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes
