Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Keynote Session: Bridging the Gap Between Basic and Clinical Alcohol-Related Research
Discussion Leader: Danielle Levitt (LSU Health Sciences Center, New Orleans, USA)
3:45 pm - 4:15 pm
Ramon Bataller (University of Pittsburgh, USA)
"Alcohol-Associated Hepatitis: Novel Targets for Therapy"
4:15 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Molecular Consequences of Ethanol Consumption
Discussion Leaders: Jianguo Wu (Cleveland Clinic, USA) and Justin Creeden (University of Toledo College of Medicine & Life Sciences, USA)
7:30 pm - 7:50 pm
Paige Anton (University of Colorado Anschutz, USA)
"Exploring Microglia Autophagic Flux Impairments as a Driver of Advanced Age and Ethanol Induced Neuroinflammation"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Liya Pi (Tulane University, USA)
"Mouse Hepatic Progenitor Cells Are Activated During NASH to HCC Transition And Are Sensitive To Ethanol Pre-exposure"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Prashanth Thevkar Nagesh (BIDMC, USA)
"In vivo Inhibition of Bruton Tyrosine Kinase (BTK) Signalosome Indicates that BTK Phosphorylation is a New Therapeutic Target in Alcoholic Liver Disease"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Lore Hoes (VIB / University of Leuven, Belgium)
"Identifying Molecular Mechanisms Underlying the Effects of Ethanol on Eukaryotic Genome Instability"
9:20 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Clinical Implications of Excessive Ethanol Use
Discussion Leaders: Paige Anton (University of Colorado Anschutz, USA) and Adam Kim (Cleveland Clinic, USA)
9:00 am - 9:20 am
Suling Zeng (University of California, San Diego, USA)
"Candida Albicans-Specific Th17 Cell-mediated Response Contributes to Alcohol- associated Liver Disease"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Danielle Levitt (LSU Health Sciences Center, New Orleans, USA)
"At-Risk Alcohol and Myoblast Bioenergetic Function in SIV/HIV"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Bhagyalakshmi Shankarappa (St John's Medical College Hospital, India)
"Genetics and Epigenetics of Alcohol Liver Cirrhosis"
10:20 am - 10:30 am
Discussion
10:30 am - 10:50 am
Qi Cao (University of Maryland School of Medicine, USA)
"Cis-4-[18F]Fluoro-L-Proline PET/CT Molecular Imaging Quantifying Liver Collagenogenesis but not Existing Fibrotic Deposition in Experimental Advanced-Stage Alcoholic Liver Fibrosis"
10:50 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Beyond the Bench: Navigating Careers in Science
Discussion Leader: Prashanth Thevkar Nagesh (BIDMC, USA)
1:30 pm - 2:30 pm
Panel Discussion
Navigating Careers in Science
Samantha Yeligar (Emory University / Atlanta VA Health Care System, USA)
Elizabeth Kovacs (University of Colorado Denver, USA)
Rebecca McCullough (University of Colorado Anschutz Medical Campus, USA)
Laura Nagy (Liver Disease Research Center, Cleveland Clinic Lerner Research Institute, USA)
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes