Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm
Keynote Session: Organ-Organ Crosstalk in Alcohol-Induced Tissue Injury
Discussion Leader: Shannon Twardy (CU Anschutz Medical Campus, United States)
3:45 pm - 3:50 pm
Introduction by Discussion Leader
3:50 pm - 4:20 pm
Derrick Samuelson (University of Nebraska Medical Center, United States)
"Gut-Lung Crosstalk in Alcohol-Associated Bacterial Pneumonia"
4:20 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cellular and Molecular Dysfunction from Ethanol Exposure
Discussion Leader: Marti Ortega (BIDMC - Harvard Medical School, United States)
7:30 pm - 7:45 pm
Eden Gallegos (Louisiana State University Health Sciences Center New Orleans, United States)
"Alcohol and Nutrient Stress Produce Differential Lipid Droplet Accumulation in Rat Primary Hepatocyte Spheroids: Implications in Alcohol-Mediated Liver Injury"
7:45 pm - 7:55 pm
Discussion
7:55 pm - 8:10 pm
Sha Neisha Williams (KUMC, United States)
"Aging Exacerbates Alcohol-Induced Steatosis and Inflammation but Not Cell Death in Mice"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:35 pm
Lenny Pommerolle (National Institutes of Health, United States)
"Lung is More Sensitive to Alcohol Effects than Liver for Immune Dysregulation: Immuno-Metabolic Role of Branch-Chain Amino Acids and mTOR Signaling"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:00 pm
Courtney McGinnis (University of Colorado - Anchutz Medical Campus, United States)
"Regulation of Hepatic Lysine N-acetylation Facilitated by Cysteine Proximity Due to Alcohol Toxicity"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Laura Tran (Rush University, United States)
"Impact of Circadian Misalignment on the Resiliency of Epithelial Barrier Function to Alcohol in Colonic Organoids"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Targeting Novel Molecular Pathways to Prevent and Treat Alcohol-Related Disease
Discussion Leader: Jianguo Wu (Cleveland Clinic, United States)
9:00 am - 9:15 am
Taylor Fitzpatrick-Schmidt (LSUHSC-New Orleans, United States)
"Cardiometabolic Risk Factors, Alcohol Use, and Cognitive Decline in People Living with HIV"
9:15 am - 9:25 am
Discussion
9:25 am - 9:40 am
Marko Mrdjen (Cleveland Clinic, United States)
"Targeted Metabolomics of Gut-Derived Microbial Metabolites in Alcohol-Associated Liver Disease"
9:40 am - 9:50 am
Discussion
9:50 am - 10:05 am
Bryan Mackowiak (National Institute on Alcohol Abuse and Alcoholism (NIH), United States)
"Albumin Protects Against Alcohol-Induced Liver Injury, Potentially by Sequestering Liver-Generated Acetaldehyde"
10:05 am - 10:15 am
Discussion
10:15 am - 10:30 am
Yilin Yang (Yale University, United States)
"Lack of Reticulon 4B (Nogo-B) Increases Endoplasmic Reticulum Sheet Structure and Facilitates Anti-Inflammatory Macrophage Polarization, Mitigating Alcohol-Associated Liver Injury"
10:30 am - 10:40 am
Discussion
10:40 am - 10:55 am
Kathryn Crotty (Emory University, Department of Medicine, United States)
"Examination of Zinc, S-adenosylmethionine, and Combination Therapy Versus Placebo in Veterans with Alcohol Use Disorders"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Building a Strong Foundation for a Career in Science
Discussion Leader: Lauren Rutt (University of Colorado Anschutz Medical Center , United States)
1:30 pm - 2:30 pm
Panel Discussion
Building a Strong Foundation for a Career in Science
Derrick Samuelson (University of Nebraska Medical Center, United States)
Leon Coleman (UNC-CH Bowles Center for Alcohol Studies, United States)
Ilhem Messaoudi (University of Kentucky, United States)
Patricia Molina (LSU Health Sciences Center New Orleans, United States)
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes