Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Clinical Phenotypes in ALS and Related Motor Neuron Diseases
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:15 pm
"Neuroanatomic Neuropathologic Correlations with ALS Phenotypes"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
"Current and Future Therapeutic Interventions in SMA"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
"Accelerating Therapy Development: Master Platform Trial Initiatives and Subgroups"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Axonal Biology and Motor Neuron Loss
9:00 am - 9:25 am
"Nuclear Transport Receptors as Regulators of Protein Aggregation and Toxicity in ALS"
9:25 am - 9:30 am
Discussion
9:30 am - 9:55 am
"Regulation of Axonal Protein Synthesis by G3BP1 Aggregation"
9:55 am - 10:00 am
Discussion
10:00 am - 10:25 am
"Axonal Transport Defects in iPSC-Derived Motor Neurons"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"A Surprising Link Between Lysosomal and RNA Biology in ALS Pathogenesis"
11:25 am - 11:30 am
Discussion
11:30 am - 11:55 am
"ALS FUS Mutations Alter Splicing and Translation Through Loss and Gain of Function"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Decoding Motor Axon Biology in Health and ALS Using Axon-Seq"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Role of RNA Binding Proteins in Motor Neuron Degeneration
7:30 pm - 7:55 pm
"Therapy Development for Disease from TDP-43 Loss and/or Gain-of-Function"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
"Pathological TDP-43 Assemblies and Their Link to Disease Heterogeneity"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:55 pm
"ALS and RNA: Thinking Outside the Nuclear Box"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Pathological Alterations of the Spinal Motor Neurons Induced by Optogenetic TDP-43 Oligomerization"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Phosphorylation Disrupts hnRNPA2 Aggregation and Alters Interactions with mRNA Transport Granule Components"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Mechanisms of Aberrant RNA Metabolism
9:00 am - 9:25 am
"Production and Toxicity of Poly(GR) in C9ORF72-ALS/FTD"
9:25 am - 9:30 am
Discussion
9:30 am - 9:55 am
"Disassembly and Reassembly of the Nuclear Pore Complex in ALS/FTD"
9:55 am - 10:00 am
Discussion
10:00 am - 10:25 am
"Therapeutic Targeting of RNA in Spinal Muscular Atrophy"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"Molecular Mechanisms Controlling Localization and Phase Separation of ALS-Linked RNA-Binding Proteins"
11:25 am - 11:30 am
Discussion
11:30 am - 11:55 am
"Pathogenic Mutations in Gemin5 Cause Early-Onset Motor Dysfunction and Cerebellar Atrophy and Disrupt snRNP Complex"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"ADAR2 Mislocalization and Widespread RNA Editing Aberrations in C9orf72-Mediated ALS/FTD"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Role of Proteinopathies in Motor Neuron Disease
7:30 pm - 7:55 pm
"Cellular and Molecular Basis of Motor Neuron Demise: From SBMA to ALS"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
"Exploiting the Androgen Receptor Interactome to Identify Pathogenic Mechanisms in SBMA"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:55 pm
"Protein Quality Control of Membraneless Organelles: Implications in ALS and Neurodegenerative Diseases"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Investigating the Mechanisms of UPF1-Mediated Rescue of TDP-43 Toxicity"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"ALS-Implicated Protein TDP-43 Sustains Levels of STMN2, a Mediator of Motor Neuron Growth and Regeneration"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Aberrant Protein Control and Related Mechanisms
9:00 am - 9:25 am
"The Nucleolus as a Protein Quality Control Compartment"
9:25 am - 9:30 am
Discussion
9:30 am - 9:55 am
"Role of the Autophagy Inducing Kinases, ULK1 and ULK2, in Degenerative Disorders"
9:55 am - 10:00 am
Discussion
10:00 am - 10:25 am
"Loss of Nuclear TDP-43 Function as a Mechanism of ALS Pathogenesis"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"Linking Selective Autophagy to Neurodegenerative Disease"
11:25 am - 11:30 am
Discussion
11:30 am - 11:55 am
"Latest Insights from Amyloid Structures: Steric Zippers and LARKS in Fibrils"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"The RNA Composition of Tau Aggregates in a Cellular Model of FTD"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Role of Neuroinflammation in Neurodegeneration
7:30 pm - 7:55 pm
"Three Subtypes of ALS: Retrotransposons, Stress and Inflammation"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
"Microglial Toxicity and TDP-43 Proteinopathy in Neurodegeneration"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:55 pm
"The Role and Mechanism of RIPK1 in Mediating Neuroinflammation and Cell Death in ALS"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"C9orf72 Functions to Suppress Systemic and Neural Inflammation Induced by Gut Microbiota"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Effects of Heterozygous Tbk1 Deletion in Old or Mutant SOD1 Transgenic Mice"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Glial Biology of Motor Neuron Diseases
9:00 am - 9:25 am
"What Do Reactive Astrocytes (Actually) Do?"
9:25 am - 9:30 am
Discussion
9:30 am - 9:55 am
"Astrocyte Hemichannels as Conduits for Motor Neuron Death in ALS"
9:55 am - 10:00 am
Discussion
10:00 am - 10:25 am
"Stage Specific Control of Oligodendrocytes by TDP-43"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"Glial Involvement in Synapse Loss in Alzheimer's Disease and ALS: Evidence from Human Post-Mortem Brain"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
"C9orf72 Deficiency Promotes Microglial Mediated Synaptic Loss in Aging or Amyloid Accumulation"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Using Patient-Derived Astrocytes to Inform Precision Medicine Approaches"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Single Cell RNA Sequencing Uncovers Disease Associated Changes in the Population Structure of Human Microglia Specific to Amyotrophic Lateral Sclerosis"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Experimental Therapeutics and Biomarkers
7:30 pm - 7:55 pm
"The New Frontier of Spinal Muscular Atrophy: When, Where and How to Mitigate a Neurodegenerative Disease"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
"RNA-Targeted Mechanisms and Therapeutics for ALS"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:55 pm
"Transforming Target Identification for Neurodegenerative Diseases: Proof of Concept in Synucleinopathies and Progress in ALS"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:15 pm
General Discussion
9:15 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure