Sunday, August 12 PM Session - 7:30-9:30 | Development & Remodeling |
Chair: Peter Carmeliet, University of Leuven
"Molecular basis of angiogenesis: Therapeutic insights from transgenic mice"
Laura Benjamin, Beth Israel Deaconess Medical Center
"Vascular Survival in Development and Disease"
Patricia D'Amore, Schepens Eye Research Institute Center
"Paracurine regulation of vessel development and stability"
Thomas Daniel, Immunex Corporation
"Juxtacrine controls in vascular cell assembly"
Monday, August 13 AM Session - 9:00-12:30 | Vasculogenesis / Angiogenesis |
Chair: Napolean Ferrara, Genentech, Inc.
"New insights on the regulation of angiogenesis by VEGF and other mediators"
Kari Alitalo, University of Helsinki
"Lymphangiogenesis"
Chris Drake, Medical University of South Carolina
"Mechanisms of vasculogenesis"
Coffee Break
Shahin Rafii, Cornell University Medical College
"Co-recruitment of hematopoietic and endothelial precursors is essential for angiogenesis"
Mary Hendrix, University of Iowa Cancer Center
"Vasculogenic embryonic patterning by aggressive melanoma tumor cells"
Guo-Hua Fong, University of Connecticut
"Potential role of Flt-1 as a signaling molecule in vasculogenesis"
Monday, August 13 PM Session - 7:30-9:30 | Molecular & Biochemical Regulation of Angiogenesis |
Chair: Luisa Iruela-Arispe, University of California, Los Angeles
Nigel Mackman, The Scripps Research Institute
"Role of the tissue factor-thrombin pathway in the regulation of blood vessels"
Celeste Simon, Howard Hughes Medical Institute
"Hypoxic regulation of developmental and tumor angiogenesis"
Joyce Bischoff, Children's Hospital, Boston
"Functional small diameter blood vessels using endothelial progenitors"
George Yancopoulos, Regeneron Pharmaceuticals, Inc.
"Roles of angiopoietins and VEGFs during normal and pathologic angiogenesis"
Dan Dumont, Sunnybrook Health Science Center, Toronto, Canada
"Conditional Angiopoietin signaling: something to live for"
Tuesday, August 14 AM Session - 9:00-12:30 | ECM & Adhesion |
Chair: Peter Brooks, New York University
"Cryptic regulatory elements within the ECM: Role in angiogenesis"
Elisabetta Dejana, Mario Negri Institute of Pharmacology Research
"The role of junctional molecules in the determination of endothelial phenotype"
Gabriele Bergers,
"Angiogenesis inhibitors in multistate tumorigenesis shows stage specific efficacy differences suggestive of underlying mechanisms"
Coffee Break
Martin Friedlander, The Scripps Research Institute
"Retinal angiogenesis: The role of integrins, MMPs and astrocytes"
Konstantin Stoletov, Albert Einstein College of Medicine, New York
"NCK and PAK participate in the signaling pathway by which VEGF activates the assembly of focal adhesion complexes"
Jiangwen Zhu, University of California, San Francisco
"Abnormal vascular morphogenesis in integrin beta 8 null mice"
Tuesday, August 14 PM Session - 7:30-9:30 | Vascular Signaling |
Chair: Timothy Hla, University of Connecticut health Center
"Sphingosine-1-phosphate signaling via the Edg-1 G-protein-coupled receptor: an essential pathway in angiogenesis"
Helen Blau, Stanford University School of Medicine
"Angiogenesis: how to orchestrate a well-tempered blood vessel"
Jan Kitajewski, Columbia University
"Notch function in vascular biology"
Carolina Mailhos, Imperial Cancer Research Fund, England
"Notch signaling in physiological and tumour angiogenesis"
Philip Hogg, University of New south Wales, Australia
"Inhibition of angiogenesis by targeting protein tyrosine phosphatases in proliferating endothelial cells"
Wednesday, August 15 AM Session - 9:00-12:30 | Blood Vessel Biology |
Chair: David Shepro
Harold Dvorak, Beth Israel Deaconess Medical Center
"Steps and mechanisms of angiogenesis"
Susan Fisher, University of California, San Francisco
"The placenta dilemma"
Coffee Break
Rakesh Jain, Massachusetts General Hospital/Harvard
"Tumor angiogenesis and microcirculation"
Donald McDonald, University of California, San Francisco Medical Center
"Endothelial cells of tumor blood vessels abnormal but not absent"
Victoria Bautch, University of North Carolina at Chapel Hill
"Imaging vascular development"
Hagit Dafni, Weizmann Institute of Science, Israel
"MRI and flourescence microscopy of the acute vascular response to VEGF165: vasodilation, hyper-permeability and lymphatic uptake followed by rapid inactivation of the growth factor"
Wednesday, August 15 PM Session - 7:30-9:30 | Angiogenesis & Cancer |
Chair: Douglas Hanahan, University of California, San Francisco
"The angiogenic switch during tumorgenesis, mechanisms and experimental therapeutics"
Robert Kerbel, Sunnybrook an Women's College Health Science Centre
"Combination anti-angiogenic drug low dose "metronomic" chemoterapy"
Randall Johnson, University of California, San Diego
"The role of hypoxia in regulating neo-vascularization"
Bjorn Olsen, Harvard Medical School
"Abnormal angiogenesis in collagen XVIII null mice"
David Milstone, Brigham and Women's Hospital, Boston
"E-selectin, endostatin and anti-angiogenesis"
Thursday, August 16 AM Session - 9:00-12:30 | New Therapeutic Strategies |
Chair: Mark Bednarski, Stanford University School of Medicine
"Molecular imaging of angiogenesis: Implications in the design of vascular targeted therapeutics"
Luisa Iruela-Arispe, University of California, Los Angeles
"The fingerprint of oncogenes on tumor-induced angiogenesis"
James Pluda, National Cancer Institute
"Clinical trial designs for the development of angiogenesis inhibitors"
Coffee Break
Jeffrey Isner, Tufts Medical School
"The heterogenous nature of endognous neovascularization"
David Shima, Imperial Cancer Research Fund, England
"Shaping the vascular tree: microvessel patterning and specialization during organogenesis"
Debabrata Mukhopadhyay, Harvard Medical School, Boston
"The neurotransmitter dopamine and VPF/VEGF-induced angiogenesis"
Thursday, August 16 7:30PM | Keynote Lecture |
Judah Folkman, Harvard Medical School, Boston
Party to follow keynote lecture
|