| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 8:15 pm | Keynote Address |
| David Anderson, Ph.D. (Caltech, California)
"Neuroangiogenesis and the control of vessel identity" |
| 8:15 pm - 9:45 pm | Endothelial Cell Progenitors |
| Discussion Leader: Luisa Iruela-Arispe, Ph.D (UCLA, California) |
| 8:15 pm - 8:35 pm | Shahin Rafii, M.D. (Cornell University Medical College, New York)
"The role of pro-angiongenic hematopoietic cells and cytokines in the regulation of post-natal vasculogenic processes" |
| 8:35 pm - 8:45 pm | Discussion |
| 8:45 pm - 9:05 pm | Shinichi Nishikawa, M.D., Ph.D. (Kyoto University Med. School, Japan)
"Differentiation and diversification of endothelial cells in vitro" |
| 9:05 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:35 pm | Giulio Cossu, M.D. (Stem Cell Research Institute, Italy)
"Mesoangioblasts, vessel associated stem cells" |
| 9:35 pm - 9:45 pm | Discussion |
| 9:45 pm | Reception |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Developmental Aspects of Angiogenesis |
| Discussion Leader: Janet Rossant, Ph.D. (Mount Sinai Hospital, Canada) |
| 9:00 am - 9:20 am | Peter Carmeliet, M.D. (Centr.Transg. Techn.en Gentherapie, Belgium)
"Genetics in mice, zebrafish and humans to decipher the molecular basis of angiogenesis" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | David Shima, Ph.D. (Eyetech, Boston)
"Coordinating the multiple effects of VEGF-A on endothelial cell behavior during microvessel network formation" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am | Group Photo / Coffee Break |
| 10:30 am - 10:50 am | Andras Nagy, Ph.D. (Mount Sinai Hospital, Canada)
"VEGF-A in organogenesis" |
| 10:50 am - 11:00 am | Discussion |
| 11:00 am - 11:20 am | George Yancopoulos, M.D., Ph.D. (Regeneron Pharma, New York)
"Requisite and collaborative roles of VEGFs and Angiopoetins during vascular development and adult remodeling" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Kari Alitalo, M.D., Ph.D. (University of Helsinki, Finland)
"Growth factor and gene programs for lymphangiogenesis" |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:20 pm | Victoria Bautch, Ph.D. (University of North Carolina at Chapel Hill)
"Opposing effects of flt-1 (VEGFR-1) on endothelial cell division and morphogenesis" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Transcriptional Regulation of Vascular Morphogenesis |
| Discussion Leader: Richard Hynes, Ph.D. (MIT, Boston) |
| 7:30 pm - 7:50 pm | Heidi Stuhlmann, Ph.D. (Scripps, California)
"Role of Vezf1 during vascular and lymphatic development" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Guillermo Oliver (St. Jude Children's Research Hospital, TN)
"Prox1 is a master regulator of lymphatic vascular formation" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Celeste Simon, Ph.D. (University of Pennsylvania)
"HIF1 alpha, HIF2 alpha, and hypoxic gene regulation during angiogenesis" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Peter Koopman, Ph.D. (University of Queensland, Australia)
"Regulation of endothelial phenotype by the transcription factor SOX18" |
| 9:20 pm - 9:30 pm | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Growth Factors and Signaling Pathways |
| Discussion Leader: Geraldine Weinmaster, Ph.D. (UCLA, California) |
| 9:00 am - 9:20 am | Jan Kitajewski, Ph.D. (Columbia University)
"Notch function in the vasculature" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Masabumi Shibuya, M.D., Ph.D. (University of Tokyo, Japan)
"VEGFR1 and R2 signaling" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:20 am | Napoleone Ferrara, M.D. (Genentech, California)
"Paracrine functions of the endothelium: Differential role of VEGFR1 and VEGFR2" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am | Coffee Break |
| 11:00 am - 11:20 am | Laura Benjamin, Ph.D. (Beth Israel Deaconess Med Cent, Boston)
"Stage-specific controls of survival and apoptosis during vascular development" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Hellmut Augustin, Ph.D. (Tumor Biology Center, Germany)
"Angiopoetins and ephrins: regulators of angiogenesis and vascular homeostasis" |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:20 pm | Judy Varner, Ph.D. (UCSD, California)
"Integrin α4ß1 regulates endothelial stem cell recruitment during neovascularization" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Paracrine Cell Interactions |
| Discussion Leader: David Anderson, Ph.D. (Caltech, California) |
| 7:30 pm - 7:50 pm | Brant Weinstein, Ph.D. (Laboratory of Molecular Genetics, NICHD, NIH, Bethesda)
"Vascular morphogenesis in the zebrafish" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Christer Betsholtz, Ph.D. (University of Goteborg, Sweden)
"Guidance of angiogenic sprouting" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Michelle Tallquist, Ph.D. (UT Southwestern Medical Center)
"Additive Effects of PDGF Receptor ß Signaling Pathways in Vascular Smooth Muscle Cell Development" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Anne Eichmann, Ph.D. (Inserm Paris, France)
"Neural genes in angiogenesis" |
| 9:20 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Permeability and Microcirculation |
| Discussion Leader: George Yancopoulos, M.D., Ph.D. (Regeneron Pharmaceuticals, New York) |
| 9:00 am - 9:20 am | William Sessa, Ph.D. (Yale University School of Medicine, Connecticut)
"Vascular permeability and tumor growth" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Guillermo Garcia-Cardena, Ph.D. (Harvard Med School, Boston)
"Control of vessel identity by fluid mechanical forces" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:20 am | Harold Dvorak, M.D. (Beth Israel Deaconess Med Ctr, Boston)
"How tumors make bad blood vessels" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am | Coffee Break |
| 11:00 am - 11:20 am | Elizabetta Dejana, Ph.D. (FIRC Institute of Molecular Oncology, Milano, Italy)
"The role of junctional proteins in endothelial cell differentiation and vascular remodeling" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Timothy Hla, Ph.D. (University of Connecticut Health Center)
"Sphingosine-1-phosphate/EDG-1 pathway in vascular maturation and homeostasis" |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:20 pm | Gabrielle Bergers, Ph.D. (UCSF, California)
"Implications of perivascular progenitor cells in tumor angiogenesis" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Extracellular Matrix and Endothelial Cell Function |
| Discussion Leader: Paul Bornstein, M.D. (University of Washington) |
| 7:30 pm - 7:50 pm | Carl Blobel, M.D., Ph.D. (Memorial Sloan-Kettering Cancer Center, New York)
"Role of ADAMs in cardiovascular morphogenesis and pathological neoangiogenesis" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | David Cheresh, Ph.D. (Scripps Res. Institute, California)
"Endothelial cell survival by growth factor- and ECM-mediated Raf activation" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Michael Simons, M.D. (Dartmouth Medical School, NH)
"Syndecan 4 and bFGF signaling" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Lisa Coussens, Ph.D. (University of California, San Francisco)
"Stromal Context Regulates Induction of Vascular Permeability: Type I Collagen-dependent Regulation of TGFß Activity" |
| 9:20 pm - 9:30 pm | Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Hereditary Vascular Abnormalities |
| Discussion Leader: Kari Alitalo, Ph.D. (Biomedicum, Finland) |
| 9:00 am - 9:20 am | Miikka Vikkula M.D., Ph.D. (Christian de Duve Institute & Universite Catholique de Louvain, Belgium)
"Genes for hereditary vascular malformations" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Joyce Bischoff, Ph.D. (Children's Hospital, Boston)
"Endothelial cell differentiation in infantile hemangioma" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:20 am | Anne Joutel, M.D. (Faculte de Medecine Lariboisiere, France)
"Molecular and cellular basis of CADASIL, a hereditary small vessel disease" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am | Coffee Break |
| 11:00 am - 11:20 am | Michelle Letarte, Ph.D. (Hospital for Sick Children, Canada)
"Vascular biology lessons from hereditary hemorrhagic telangectasia" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Eli Keshet, Ph.D. (The Hebrew University-Hadassah Medical School)
"Induction of vascular networks in adult organs" |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:20 pm | Robert Benezra, M.D. (Memorial Sloan-Kettering Cancer, NY)
"Modeling the effects of angiogenesis inhibition on spontaneous murine tumors" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Angiogenesis and Cancer |
| Discussion Leader: Judah Folkman, M.D. (Children's Hospital Boston) |
| 7:30 pm - 7:50 pm | Renata Pasqualini, Ph.D. / Wadih Arap (University of Texas)
"Probing molecular diversity for the development of targeted therapies" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Douglas Hanahan, Ph.D. (University of California, San Francisco)
"The angiogenic vasculature during tumorigenesis: mechanisms and interventions" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Rakesh Jain, Ph.D. (Massachusetts General Hospital)
"Angiogenesis and lymphangiogenesis in tumors: insights from intravital microscopy" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Vikas Sukhatme, M.D., Ph.D. (Harvard Medical School, Boston)
"Angiogenesis Inhibitors and Novel Insights into Preeclampsia" |
| 9:20 pm - 9:30 pm | Discussion |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |
