| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | BASIC CONCEPTS IN VASCULAR MORPHOGENESIS |
| Welcome: Elisabetta Dejana (FIRC Inst Mol Oncology, Milan, Italy) |
| 7:30 pm - 8:30 pm | Mark A. Krasnow (Howard Hughes Med. Inst, Stanford, CA)
"Genetic dissection of epithelial tube formation and branching" |
| 8:30 pm - 9:30 pm | Marc Tessier Lavigne (Genentech, San Francisco, US)
"The logic and molecular mechanisms of axon guidance: implications for angiogenesis" |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | BLOOD VESSEL GUIDANCE AND SPECIFICATION |
| Discussion Leader: Michael Klagsbrun (Children's Hospital, Harvard Medical School) |
| 9:00 am - 9:30 am | Ralf Adams (Vasc Dev Lab Cancer Res UK London Res Inst, London, UK)
"Regulation of vessel wall assembly by ephrinB2-EphB interactions" |
| 9:30 am - 10:00 am | David Anderson (CALTECH, Pasadena, CA)
"Novel genes that regulate endothelial differentiation" |
| 10:00 am | Coffee Break / Photo |
| 10:30 am - 11:00 am | Federico Bussolino (Universita' di Torino, Torino, Italy)
"Neuropilins: a bridge between neural and vascular systems" |
| 11:00 am - 11:30 am | Anne Eichmann (College de France, Paris, France)
"Axon guidance cues in vascular development" |
| 11:30 am - 11:50 am | Diane Bielenberg (Children's Hospital, Harvard Medical School)
"Chemorepulsion of endothelial cells and lymphatic endothelial cells" |
| 11:50 am - 12:10 pm | Ramani Ramchandran (Center for Cancer Research, National Cancer Institute, NIH, Rockville MD)
"Roundabout4's function and signaling mechanism in vertebrate vascular development" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | BONE MARROW DERIVED HEMANGIOGENIC PROGENITORS |
| Discussion Leader: David T. Scadden (Harvard Stem Cell Institute, Center for Regenerative Medicine & Technology, Massachusetts General Hospital, Boston, MA) |
| 7:30 pm - 8:00 pm | Shahin Raffii (Weill-Cornell Medical College, New York)
"Regulation of angiogenesis by hematopoietic cytokines and progenitors" |
| 8:00 pm - 8:30 pm | Eli Keshet (Hebrew Univ -Hadassah Med School, Jerusalem, Israel)
"VEGF-induced recruitment of circulating cells" |
| 8:30 pm - 9:00 pm | Stephanie Dimmeler (Molecular Cardiology, Univ Frankfurt, Germany)
"Molecular mechanism regulating homing and differentiation of endothelial progenitor cells" |
| 9:00 pm - 9:20 pm | Michele de Palma (Angiogenesis and Tumor Targeting Res Unit, San Raffaele Scientific Inst, Milan, Italy)
"Tie2 expression identifies a lineage of pro-angiogenic monocytes and a population of pericyte progenitors responsible for tumor vascularization" |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | THE DEVELOPMENT OF THE CARDIOVASCULAR SYSTEM IN LOWER VERTEBRATES AND IN THE MOUSE EMBRYO |
| Discussion Leader: Anne Eichmann (College de France, Paris, France) |
| 9:00 am - 9:30 am | Brant Weinstein (Unit on Vertebrate Organogenesis, Lab of Mol Gen, NIH, Bethesda)
"Assembly of vascular networks during early development" |
| 9:30 am - 10:00 am | Peter Carmeliet (Center for Transgene Technology & Gene Therapy, University of Leuven, Leuven, Belgium)
"Blood vessels, lymphatics and nerves" |
| 10:00 am - 10:30 am | Didier Stainier (University of California, San Francisco, CA)
"Vasculogenesis in zebrafish" |
| 10:30 am | Coffee Break |
| 11:00 am - 11:20 am | Daniel Dumont (Molecular and Cellular Biology, Sunnybrook & Women's Research Institute, Toronto, Canada)
"Angiopoietin Signaling in Health and Disease" |
| 11:20 am - 11:40 am | Christopher Drake (Cell Biol and Anatomy BSB, Charleston, SC)
"VEGF And Vasculogenesis" |
| 11:40 am - 12:00 pm | Masataka Majima (Department of Pharmacology, Kitasato University School of Medicine, Japan)
"Angiotensin Type 1a Receptor Signaling in Host Stroma Facilitates Tumor Angiogenesis" |
| 12:00 pm - 12:20 pm | Short Talk |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | REGULATION OF ANGIOGENESIS BY HYPOXIA AND GROWTH FACTORS |
| Discussion Leader: Peter Carmeliet (Center for Transgene Technology & Gene Therapy, University of Leuven, Leuven, Belgium) |
| 7:30 pm - 8:00 pm | Celeste Simon (University of Pennsylvania Cancer Center, Philadelphia)
"HIFs, hypoxia, and tumor angiogenesis" |
| 8:00 pm - 8:30 pm | Peter J. Ratcliffe (University of Oxford, Oxford, UK)
"Role of the HIF hydroxylases in directing the cellular response to oxygen availability" |
| 8:30 pm - 9:00 pm | Lena Claesson-Welsh (Dept. Genetics and Pathology, Uppsala Univ., Uppsala, Sweden)
"Regulation of VEGF receptor signal transduction and biological function" |
| 9:00 pm - 9:30 pm | Laura Benjamin (Beth Israel Deaconess Medical Center, Harvard Medical School, Boston)
"Akt signaling in normal and pathological vascular development" |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | GROWTH FACTORS AND THEIR SIGNALLING PATHWAYS |
| Discussion Leader: Harold F. Dvorak (Beth Israel Deaconess Medical Center, Harvard Medical School, Boston) |
| 9:00 am - 9:30 am | Kari Alitalo (Biomedicum Helsinki, Univ. Of Helsinki, Finland)
"Lymphangiogenesis in development, inflammation and cancer metastasis" |
| 9:30 am - 10:00 am | Masabumi Shibuya (Division of Genetics, Institute of Medical Science, University of Tokyo, Japan)
"VEGF-receptor signaling towards angiogenesis and vascular permeability" |
| 10:00 am - 10:20 am | Tuomas Tammela (Biomedicum Helsinki, Univ. of Helsinki, Finland)
"Lymphangiogenesis in development, inflammation and cancer metastasis" |
| 10:30 am | Coffee Break |
| 11:00 am - 11:30 am | David Cheresh (Scripps Clinic, San Diego, CA)
"Vascular response to growth factors and the extracellular environment" |
| 11:30 am - 12:00 pm | Donald McDonald (Comprehensive Cancer Center, University of California, San Francisco)
"Cellular actions of angiogenesis inhibitors on blood vessels" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | THE INFLUENCE OF MICROENVIRONMENT IN VASCULAR MORPHOGENESIS |
| Discussion Leader: Michael Gimbrone (Harvard Medical School, Brigham & Women's Hospital, Boston) |
| 7:30 pm - 8:00 pm | Richard Hynes (Center for Cancer Research, MIT, Cambridge, MA)
"Angiogenesis in the CNS and Lymphangiogenesis in Metastasis" |
| 8:00 pm - 8:30 pm | Luisa Iruela Arispe (Dept. of Molecular, Cell and Dev. Biology - UCLA, Los Angeles, CA)
"Extracellular Matrix Connections and their Role in Maintenance of Vascular Patency" |
| 8:30 pm - 9:00 pm | Hellmut Augustin (Tumor Biology Center Freiburg, Freiburg, Germany)
"Regulation of vascular homeostasis by angiogenic cytokines" |
| 9:00 pm - 9:30 pm | Raghu Kalluri (Center for Matrix Biology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston)
"Matrix Microenvironment in Cancer Progression and Metastasis" |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | PARACRINE CELLULAR SIGNALLING |
| Discussion Leader: Doug Hanahan (Univ of California, San Francisco,CA) |
| 9:00 am - 9:30 am | Doug Hanahan (Univ of California, San Francisco,CA)
"Angiogenic mechanisms and multi-targeting of the tumor vasculature" |
| 9:30 am - 10:00 am | Gabriele Bergers (University of California, San Francisco, CA)
"The role of pericytes in tumor angiogenesis" |
| 10:00 am - 10:30 am | Jeff Pollard (Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, New York)
"Macrophages and angiogenesis in the tumor micro-enviroment" |
| 10:30 am | Coffee Break |
| 11:00 am - 11:30 am | William Sessa (Yale Univ., New Haven, CT)
"Role of Nogo and its receptor during angiogenesis" |
| 11:30 am - 11:50 am | Michelle Letarte (Hospital for Sick Children and University of Toronto, Toronto, Canada)
"Activation of the ALK-1 pathway in endoglin null endothelial cells" |
| 11:50 am - 12:10 pm | Sujata Rao (Division of Dev biol and Dept Opthamol, Children's Hospital Research Foundation, Cincinnati, Oh)
"Macrophage wnt7b mediates programmed vascular regression" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | NOVEL STRATEGIES TO MODULATE ANGIOGENESIS IN IN VIVO MODELS |
| Discussion Leader: Judah Folkman (Children's Hospital, Boston, MA) |
| 7:30 pm - 8:00 pm | Rakesh Jain (Harvard Medical School, Boston, MA)
"Anti-angiogenesis and vascular normalization in tumors: From bench to bedside and back" |
| 8:00 pm - 8:30 pm | David Shima (Eyetech Research Center, Woburn, MA)
"Multiple Irons in the Fire: Developing a scientific rationale for combination therapies to treat neovascular disease" |
| 8:30 pm - 8:50 pm | Lucie Kopfstein (Inst Biochem and Genetics, Basel, Switzerland)
"Differential effects of VEGF family members during tumor progression" |
| 8:50 pm - 9:10 pm | Andrea Banfi (Basel University Hospital, Basel, Switzerland)
"The threshold between VEGF-induced normal and aberrant angiogenesis is determined by the balance between VEGF-A and PDGF-BB signaling" |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |
