Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: New Frontiers in Angiogenesis and Endothelial Cell Physiology
Discussion Leader: Shahin Rafii (Weill Cornell Medicine, USA)
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
Gregg Semenza (Johns Hopkins University, USA)
"Hypoxia/HIF: From Basic Mechanisms to Therapeutics"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Peter Carmeliet (VIB-KU Leuven Center for Cancer Biology, Belgium)
"Metabolic Regulation of Angiogenesis: Therapeutic Implications"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Didier Stainier (Max Planck Institute for Heart and Lung Research, Germany)
"Endothelial Cell Differentiation and Behavior in Zebrafish"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Transcriptional Regulation of Vasculogenesis and Angiogenesis
Discussion Leader: Anne Eichmann (Yale School of Medicine, USA)
9:00 am - 9:20 am
Elisabetta Dejana (IFOM - The FIRC Institute of Molecular Oncology, Italy)
"Transcriptional Regulation of the Blood Brain Barrier Differentiation"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Anna Randi (Imperial College London, United Kingdom)
"Transcriptional Control of Endothelial Homeostasis and Lineage Specification"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Nathan Lawson (University of Massachusetts Medical School, USA)
"A Conserved Transcriptional Regulatory Pathway Controls Lymphatic Valve Formation in the Zebrafish"
10:20 am - 10:30 am
Discussion
10:30 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
Gou Young Koh (Institute for Basic Science / Korea Advanced Institute of Science and Technology, South Korea)
"Regulation of the Hippo-YAP Pathway in Angiogenesis and Vascular Maturation"
11:15 am - 11:25 am
Discussion
11:25 am - 11:35 am
Brisa Palikuqi (Weill Cornell Graduate School of Medical Sciences, USA)
"Engineering Stable, Durable and Functional Vessels for Organ Regeneration"
11:35 am - 11:40 am
Discussion
11:40 am - 12:00 pm
Mervin Yoder (University of Indiana School of Medicine, USA)
"Identification of the Endothelial Stem Cells"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Building and Remodeling Stable Endothelial Cell Tubular Networks
Discussion Leader: Donald McDonald (University of California, San Francisco, USA)
7:30 pm - 7:50 pm
Holger Gerhardt (VIB Center for Cancer Biology, KU Leuven, Germany)
"Shaping and Remodelling Vascular Networks in Development"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Christer Betsholtz (Integrated Cardio Metabolic Centre (ICMC), Karolinska Institutet, Sweden)
"Single Cell Transcriptomics of the Vasculature"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Pouneh Kermani (Weill Cornell Medicine, USA)
"Endothelial Cell-Derived Laminin Gamma-1 Is Required for Neo-Angiogenesis in Development and Wound Healing"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
Luisa Iruela-Arispe (University of California, Los Angeles, USA)
"Critical Signaling Nodes in Vascular Homeostasis"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Andrea Banfi (Basel University Hospital, Switzerland)
"A Pericyte-Independent Role for PDGF-BB in Vascular Stabilization by Stimulating the Sema3A/Nrp1+ Monocyte Axis"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Integration of Signaling Pathways in Angiogenesis
Discussion Leader: Victoria Bautch (The University of North Carolina at Chapel Hill, USA)
9:00 am - 9:20 am
Jan Kitajewski (University of Illinois at Chicago, USA)
"Cell Fate Mechanisms that Drive the Angiogenic Process"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Napoleone Ferrara (University of California, San Diego, USA)
"Novel Pathways in Angiogenic Signaling"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Lena Claesson-Welsh (Uppsala University, Sweden)
"VEGF Receptors and Signaling Crosstalk"
10:20 am - 10:30 am
Discussion
10:30 am - 10:55 am
Coffee Break
10:55 am - 11:05 am
Roxana Ola (Yale School of Medicine, USA)
"Smad4 Acts Downstream of BMP9/10-Alk1 in Early Retina Angiogenesis"
11:05 am - 11:10 am
Discussion
11:10 am - 11:30 am
Kari Alitalo (Wihuri Research Institute / University of Helsinki, Finland)
"Structuring Angiopoietin-Tie Signaling Functions"
11:30 am - 11:40 am
Discussion
11:40 am - 12:00 pm
Susan Quaggin (Northwestern University, USA)
"High Tek Treatment of Ocular Maladies"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Homeostasis and Metabolism in Angiogenesis
Discussion Leader: Zoltan Arany (University of Pennsylvania, USA)
7:30 pm - 7:50 pm
David Cheresh (University of California, San Diego, USA)
"Reprogramming the Endothelium During Tissue Remodeling"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Michael Simons (Yale School of Medicine, USA)
"Metabolic Control of Development"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Boa Kim (University of Pennsylvania, USA)
"Glutamine Metabolism in Endothelial Cells"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
Michael Potente (Max Planck Institute for Heart and Lung Research, Germany)
"Metabolite Signaling in the Endothelium"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Steven Swendeman (Boston Children's Hospital, USA)
"An Engineered S1P Chaperone Attenuates Hypertension and Ischemic Injury"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Tissue-Specific Endothelial Instructive Function and Heterogeneity in Regeneration
Discussion Leader: Hellmut Augustin (Heidelberg University / German Cancer Research Center, Germany)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Eli Keshet (The Hebrew University of Jerusalem, Israel)
"Intra-Tumor Diversification Driven by Adjacency to Blood Vessels"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Jason Butler (Weill Cornell Medicine, USA)
"Regulation of the Hematopoietic Stem Cell Lifecycle by the Endothelial Niche"
9:55 am - 10:05 am
Discussion
10:05 am - 10:25 am
Ondine Cleaver (University of Texas Southwestern Medical Center, USA)
"Heterogeneity of Blood Vessel Tubulogenesis"
10:25 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Michael Detmar (ETH Zurich, Switzerland)
"Cutaneous Lymphatic Vessel Contribution to Regeneration and Immunity"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Mahak Singhal (German Cancer Research Center, Germany)
"Tracing the Origin of Endothelial Cells During Liver Regeneration"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Mark Kahn (University of Pennsylvania, USA)
"Microbiome Regulation of Vascular Heterogeneity"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Endothelial Plasticity and Adapative Response to Mechanotransduction and Patterning
Discussion Leader: Timothy Hla (Harvard Medical School, USA)
7:30 pm - 7:50 pm
Tatiana Byzova (Cleveland Clinic, USA)
"Vascular Patterning Control by Resident Immune Cells"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Martin Schwartz (Yale School of Medicine, USA)
"Regulation of the Endothelial Phenotype by Fluid Shear Stress"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Anne Karine Lagendijk (Institute for Molecular Biology, University of Queensland, Australia)
"Live Imaging Molecular Changes in Junctional Tension upon VE-Cadherin in Zebrafish"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
Christopher Chen (Boston University / Wyss Institute for Biologically Inspired Engineering, Harvard University, USA)
"Forces, Adhesions, and the Regulation of Vascular Form and Function: Insights from Engineered Cultures"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Dritan Agalliu (Columbia University Medical Center, USA)
"The Wnt Inhibitor Apcdd1 Coordinates Vascular Remodeling and Barrier Maturation in Retinal Blood Vessels"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Maladaptive Angiogenesis in Tumor Growth and Inflammation
Discussion Leader: Harold Dvorak (Beth Israel Deaconess Medical Center, USA)
9:00 am - 9:20 am
Robert Kerbel (Sunnybrook Research Institute, Canada)
"Impact of Vessel Co-Option in Metastases on Antiangiogenic Efficacy"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Gabriele Bergers (VIB-KU Leuven Center for Cancer Biology, Belgium)
"High Endothelial Venules in Cancer"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Gavin Thurston (Regeneron Pharmaceuticals, Inc, USA)
"Endothelial Cell Participation in the Tumor Microenvironment"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Bi-Sen Ding (Weill Cornell Medicine, USA)
"Maladapted Endothelial Niche Provokes Lung Fibrosis"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Andreas Fischer (German Cancer Research Center, Germany)
"Angiocrine Functions of Endothelial Notch Signaling"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Masataka Majima (Kitasato University School of Medicine, Japan)
"Prostaglandins as Regulators of Neovascularization"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Keehoon Jung (Harvard Medical School / Massachusetts General Hospital, USA)
"Real-Time Intravital Characterization of Non-Classical Monocytes to Improve Anti-Angiogenic Cancer Therapy"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Translational Vascular Medicine: Organ Repair and Tumor Targeting
Discussion Leader: Laura Benjamin (KatahdinRx, USA)
7:30 pm - 7:50 pm
Rakesh Jain (Harvard Medical School / Massachusetts General Hospital, USA)
"Reprogramming the Tumor Microenvironment Using Angiotensin Receptor Blockers to Enhance Cancer Treatment: Bench to Bedside"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Valerie Lebleu (University of Texas MD Anderson Cancer Center, USA)
"Exploring the Connection Between Vascular Plasticity and Immune Response in Tissue Regeneration and Cancer Progression"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Weilan Ye (Genentech, Inc., USA)
"Modulating EC-ECM Adhesion to Alter Drug Delivery and Lymphocyte Trafficking"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Julie Scotton (ISREC CMSO, Switzerland)
"Combinatorial Targeting of Tumor Angiogenesis with Inducers of Autophagy in the Treatment of Gliomas"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Raghu Kalluri (University of Texas MD Anderson Cancer Center, USA)
"Functional Contribution of Vascular Heterogeneity in Organotropic Metastasis"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure