Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: New Frontiers in Angiogenesis and Endothelial Cell Physiology
Discussion Leader: Hellmut Augustin (Heidelberg University / German Cancer Research Center, Germany)
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 8:10 pm
Eric Olson (University of Texas Southwestern Medical Center, USA)
"Exploring Muscle Development, Disease and Regeneration"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Maiken Nedergaard (University of Rochester, USA)
"The Glymphatic System"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Rakesh Jain (Harvard Medical School / Massachusetts General Hospital, USA)
"Reprogramming the Tumor Microenvironment to Enhance Cancer Treatment: Bench to Bedside"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Signaling Pathways and Networks
Discussion Leader: Gavin Thurston (Regeneron Pharmaceuticals, Inc., USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Susan Quaggin (Northwestern University, USA)
"Overcoming TEKnical Challenges on the Road to New Vascular Therapies"
9:30 am - 9:40 am
Discussion
9:40 am - 9:50 am
Selected from Poster Abstracts: Donato Inverso (German Cancer Research Center, Germany)
"The Tyrosine Kinase Receptor Tie1 Shapes Different Organo-Specific Wnt Codes"
9:50 am - 9:55 am
Discussion
9:55 am - 10:15 am
Lena Claesson-Welsh (Uppsala University, Sweden)
"Organotypic Regulation of the Vascular Barrier"
10:15 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
Shahin Rafii (Weill Cornell Medicine, USA)
"Designer Adaptable Endothelium to Decipher Vascular Heterogeneity"
11:15 am - 11:25 am
Discussion
11:25 am - 11:35 am
Selected from Poster Abstracts: Weijun Pan (Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, China)
"CDS2 Deficiency Converts Outcome of VEGFa Signaling from Angiogenesis to Vascular Regression"
11:35 am - 11:40 am
Discussion
11:40 am - 12:00 pm
Kari Alitalo (Wihuri Research Institute / University of Helsinki, Finland)
"Eavesdropping Cardiovascular Regulation at Single Cell Level"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizer: Ondine Cleaver (University of Texas Southwestern Medical Center, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Developmental Fate, Plasticity and Differentiation
Discussion Leader: Ondine Cleaver (University of Texas Southwestern Medical Center, USA)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
Nobuyuki Takakura (Osaka University, Japan)
"Angiocrine Signals and Epithelial Mesenchymal Transition"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:20 pm
Selected from Poster Abstracts: Ruben Marin-Juez (Max Planck Institute for Heart and Lung Research, Germany)
"Coronary Revascularization After Injury Is Regulated by Endocardial and Epicardial Cues and Forms a Scaffold for Cardiomyocyte Regeneration"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:45 pm
Karina Yaniv (Weizmann Institute of Science, Israel)
"Novel Mechanisms Regulating Early Vascular Development"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:00 pm
Selected from Poster Abstracts: Andre Rosa (Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Germany)
"Was Controls Cell Migration During Vascular Remodeling"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
Nathan Lawson (University of Massachusetts Medical School, USA)
"Investigating the Embryonic Origins of Endothelial Heterogeneity"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Vascular Control of Organ Function
Discussion Leader: Holger Gerhardt (Max Delbrück Center for Molecular Medicine, Germany)
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
Tatiana Petrova (Lausanne University Hospital / University of Lausanne, Switzerland)
"Mechanisms of Vascular Specialization in Lymph Node and Intestine"
9:35 am - 9:45 am
Discussion
9:45 am - 10:05 am
Sergij Goerdt (University Medical Center Mannheim / Heidelberg University, Germany)
"Hepatic Angiodiversity: Vascular Control of Liver Function and Disease"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
Selected from Poster Abstracts: Jesus Gomez Salinero (Weill Cornell Medicine, USA)
"Molecular Determinants of Intrahepatic Vascular Zonation"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Anne Eichmann (Yale School of Medicine, USA)
"Guidance of Vascular Barrier Formation"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Selected from Poster Abstracts: Junhao Hu (Interdisciplinary Research Center on Biology and Chemistry, China)
"Activating NO-sGC Pathway in Pericytes Ameliorates Inflammation-Induced Lung Injury"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Carmen Ruiz de Almodovar (Heidelberg University, Germany)
"Vascular Control of Oligodendrocyte Precursor Specification"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Selected from Poster Abstracts: Katrien De Bock (ETH Zurich, Switzerland)
"Angiocrine Metabolic Signaling Controls Muscle Regeneration by Instructing Macrophage Functional Polarization"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Remodeling of the Aging Vasculature
Discussion Leader: Eli Keshet (The Hebrew University of Jerusalem, Israel)
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
Stefanie Dimmeler (Goethe-University Frankfurt, Germany)
"Cellular Heterogeneity and Plasticity in Vascular Growth"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Michael Simons (Yale University School of Medicine, USA)
"Vascular Cell Heterogeneity and Disease"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Selected from Poster Abstracts: Vijay Jidigam (Cole Eye Institute, Cleveland Clinic, USA)
"Role of Circadian Clock Gene in Retinal Vascular Remodeling"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Luisa Iruela-Arispe (University of California, Los Angeles, USA)
"Building Resilience in the Vascular Wall"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Differentiation and Functions of Organotypic Vasculatures
Discussion Leader: Donald McDonald (University of California, San Francisco, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Christiana Ruhrberg (University College London, United Kingdom)
"The Heterogenous Origin of Endothelial Cells in Blood and Lymphatic Vasculature"
9:30 am - 9:40 am
Discussion
9:40 am - 9:50 am
Selected from Poster Abstracts: Anne Ryan (University of Texas Southwestern Medical Center, USA)
"Kidney Organoids as a Dual Model of Vascular Regression and Angiocrine Signaling"
9:50 am - 9:55 am
Discussion
9:55 am - 10:15 am
Andreas Fischer (German Cancer Research Center, Germany)
"Endothelial Cells in Adipose Tissue"
10:15 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
Courtney Griffin (Oklahoma Medical Research Foundation, USA)
"How Chromatin-Remodeling Enzymes Reveal Insights into Organ-Specific Vascular Development and Maintenance"
11:15 am - 11:25 am
Discussion
11:25 am - 11:35 am
Selected from Poster Abstracts: Sudarshan Anand (Knight Cancer Institute, Oregon Health and Science University, USA)
"DNA Methylation of a Non-Coding RNA Cluster and Endothelial Cell Fates"
11:35 am - 11:40 am
Discussion
11:40 am - 12:00 pm
Eckhard Lammert (Heinrich Heine University Düsseldorf, Germany)
"Mechanically Induced Angiocrine Signals"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Novel Technological Developments to Study Vascular Morphogenesis
Discussion Leader: Laura Benjamin (Oncologie, Inc., USA)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
Bin Zhou (Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China)
"Genetic Targeting of Organ Specific Vessels"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:15 pm
Selected from Poster Abstracts: Daniel Shaye (University of Illinois at Chicago, USA)
"EXC-4/CLIC Proteins Are Ancient Regulators of Rho-Family GTPase Signaling in Tubulogenesis and Angiogenesis"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
Rui Benedito (Centro Nacional de Investigaciones Cardiovasculares (CNIC), Spain)
"Using Multispectral Genetic Mosaics to Enlighten Vascular Cell Heterogeneity"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Selected from Poster Abstracts: Sarah De Val (University of Oxford, United Kingdom)
"Regulatory Pathways Governing Coronary Vessel Development Are Dysregulated After Myocardial Infarction in the Adult Heart"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Timothy Hla (Boston Children's Hospital / Harvard Medical School, USA)
"Transcriptional Basis of How S1P Regulates Primary Vascular Network Formation"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Systems Biology Approaches Towards Angiogenesis and Vascular Differentiation
Discussion Leader: Christer Betsholtz (Uppsala University, Sweden)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Joanna Kalucka (VIB-KU Leuven Center for Cancer Biology, Belgium)
"Angiogenesis Revisited: The Role and (Therapeutic) Implications of Endothelial Metabolism"
9:30 am - 9:40 am
Discussion
9:40 am - 9:50 am
Selected from Poster Abstracts: Jorge Andrade (Angiogenesis and Metabolism Laboratory, Max Planck Institute for Heart and Lung Research, Germany)
"Control of Endothelial Quiescence by FOXO Regulated Metabolites"
9:50 am - 9:55 am
Discussion
9:55 am - 10:15 am
Stefania Nicoli (Yale University, USA)
"N-Glycome Regulation Limits the Endothelial Transition to Hematopoietic Stem Cells"
10:15 am - 10:25 am
Discussion
10:25 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
Selected from Poster Abstracts: Georgia Zarkada (Yale University, USA)
"TGFβ Signaling in Vascular Development"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
Anna Randi (Imperial College London, United Kingdom)
"Transcription Networks Regulating Endothelial Lineage and Function"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Selected from Poster Abstracts: Mariona Graupera (Bellvitge Biomedical Research Institute (IDIBELL), Spain)
"Low PI3-Kinase Signaling Permits Pericyte Maturation During Angiogenesis"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Mark Kahn (University of Pennsylvania, USA)
"Hemodynamic Regulation of Valve Development and Function"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Angiogenesis in Disease and Vascular Targeted Therapies
Discussion Leader: Robert Kerbel (Sunnybrook Research Institute, Canada)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
Anjali Kusumbe (University of Oxford, United Kingdom)
"Organotypic Angiocrine Signatures in Aging Tissue Compartments"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Michele De Palma (École Polytechnique Fédérale de Lausanne, Switzerland)
"Anti-Angiogenic Immunotherapy"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
Selected from Poster Abstracts: Mahak Singhal (European Center for Angioscience (ECAS), Germany)
"Temporal Multi-Omics Identifies LRG1 as Vascular Niche Instructor of Early Metastatic Colonization"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:15 pm
Raghu Kalluri (University of Texas MD Anderson Cancer Center, USA)
"New Insights into the Functional Role of Organ Specific Vasculature and Cell Specific Tumor Stroma in Cancer Progression and Metastasis"
9:15 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure