| SATURDAY |
| 1:00 pm - 5:00 pm | Arrival and Check-in |
| 3:30 pm - 3:45 pm | Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair |
| 3:45 pm - 4:30 pm | Keynote Session |
| Discussion Leader: Valerie LeBleu (University of Texas MD Anderson Cancer Center, Houston, TX) |
| 3:45 pm - 4:15 pm | Celeste Simon (University of Pennsylvania School of Medicine, Philadelphia, PA)
"Oxygen availability, angiogenesis, and disease"
|
| 4:15 pm - 4:30 pm | Discussion |
| 4:30 pm - 6:00 pm | Poster Session I |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Constructing the Vascular Network |
| Discussion Leader: Valerie LeBleu (University of Texas MD Anderson Cancer Center, Houston, TX) |
| 7:30 pm - 7:50 pm | Lena Claesson-Welsh (Uppsala University, Uppsala, Sweden)
"VEGF and vascular permeability; what is the role?" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:10 pm | Bing Zhang (Harvard Medical School/Boston Children's Hospital, Boston, MA)
"A dynamic H3K27ac signature identifies VEGFA-stimulated endothelial enhancers and requires EP300 activity" |
| 8:10 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:25 pm | John Chappell (University of North Carolina, Chapel Hill, NC)
"Dynamic imaging of developing blood vessels reveals unique aspects of endothelial cell sprouting and vascular network formation" |
| 8:25 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:40 pm | Julie Mund (Indiana University Simon Cancer Center, Indianapolis, IN)
"Human Proangiogenic circulating hematopoietic stem and progenitor cells promote tumor growth in an orthotopic melanoma xenograft model" |
| 8:40 pm - 8:45 pm | Discussion |
| 8:45 pm - 8:55 pm | Maria Radu (Fox Chase Cancer Center, Philadelphia, PA)
"The role of Pak2 in the development and maintenance of a healthy endothelium" |
| 8:55 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:10 pm | Marco Morini (IFOM-IEO Campus, Milan, Italy)
"VE-cadherin orchestrates epigenetic modifications aimed at endothelial stabilization" |
| 9:10 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:30 pm | General Discussion |
| SUNDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 11:00 am | Vascular Heterogeneity |
| Discussion Leader: Celeste Simon (University of Pennsylvania School of Medicine, Philadelphia, PA) |
| 9:00 am - 9:20 am | Shahin Rafii (Weill Cornell Medical College, New York City, NY)
"Transcriptional hierarchy regulating vascular stability and maturity" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:40 am | Longhou Fang (University of California San Diego, San Diego, CA)
"Cholesterol efflux facilitated by AIBP limits angiogenesis" |
| 9:40 am - 9:45 am | Discussion |
| 9:45 am - 9:55 am | Sara Zanivan (Beatson Institute for Cancer Research, Glasgow, United Kingdom)
"Proteomic dissection of endothelial morphogenesis unveils tumor angiogenic markers and metabolic remodeling" |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am - 10:10 am | Ceen Ming Tiffany Tang (University of Oxford, Oxford, United Kingdom)
"Development of HIF-1 Inhibitors" |
| 10:10 am - 10:15 am | Discussion |
| 10:15 am - 10:25 am | Melanie Uebelhoer (De Duve Institute, Brussels, Belgium)
"Venous malformation-causative TIE2 mutations mediate an AKT-dependent decrease in PDGFB" |
| 10:25 am - 10:30 am | Discussion |
| 10:30 am - 10:40 am | James Dunleavey (University of North Carolina, Chapel Hill, NC)
"Vascular channel formation by a novel subpopulation of CD31+ melanoma cells" |
| 10:40 am - 10:45 am | Discussion |
| 10:45 am - 11:00 am | General Discussion |
| 11:00 am - 12:30 pm | Poster Session II |
| Coffee will be served in the poster area from 11:00 am - 11:30 am |
| 12:30 pm | Lunch |
| 1:30 pm - 2:40 pm | Controlling Tumor Angiogenesis |
| Discussion Leader: Lena Claesson-Welsh (Uppsala University, Uppsala, Sweden) |
| 1:30 pm - 1:50 pm | Kari Alitalo (University of Helsinki, Helsinki, Finland)
"Functional and therapeutic insights on vascular growth factors" |
| 1:50 pm - 2:00 pm | Discussion |
| 2:00 pm - 2:15 pm | Kshitij Srivastava (German Cancer Research Institute, Heidelberg, Germany)
"Postsurgical adjuvant tumor therapy: Exploiting novel combinations to limit metastasis" |
| 2:15 pm - 2:20 pm | Discussion |
| 2:20 pm - 2:35 pm | Nicolo Rigamonti (Swiss Federal Institute of Technology, Lausanne, Switzerland)
"Overcoming tumor resistance to VEGF blockade by co-targeting ANG2/TIE2 signaling" |
| 2:35 pm - 2:40 pm | Discussion |
| 2:40 pm - 3:00 pm | Evaluation Period |
| Fill out GRS Evaluation Forms |
| 3:00 pm | Gordon Research Seminar ends. For those attending the associated Gordon Research Conference, please check in at the GRC Office beginning at 4:00 pm. |
