| Saturday |
| 2:00 pm - 5:00 pm | Arrival and Check-in |
| 3:30 pm - 3:45 pm | Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair |
| 3:45 pm - 4:30 pm | Keynote Session: Vessel Homeostasis |
| Discussion Leader: Véronique Gebala (Max Delbrueck Centre for Molecular Medicine, Germany) |
| 3:45 pm - 4:20 pm | Luisa Iruela-Arispe (University of California, Los Angeles, USA)
"Regulation of Endothelial Homeostasis: Staying Still Requires Hard Work" |
| 4:20 pm - 4:30 pm | Discussion |
| 4:30 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Dynamics of Vessel Development |
| Discussion Leaders: Kyle Harrington (Beth Israel Deaconess Medical Center, USA) and Danielle Nagelberg (New York University School of Medicine / Skirball Institute of Biomolecular Medicine, USA) |
| 7:30 pm - 7:50 pm | Heinz-Georg Belting (Biozentrum, University of Basel, Switzerland)
"Cellular Mechanisms of Endothelial Cell Behavior During Angiogenic Sprouting and Anastomosis" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:10 pm | Swapna Ravikumar (University of Bern, Switzerland)
"Intussusceptive Angiogenesis in Zebrafish Model" |
| 8:10 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:25 pm | Christine Yoon (Boston University, USA)
"VEGF Gradients and the Effects on the Collective Invasion of Endothelial Cells During Angiogenic Sprouting" |
| 8:25 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:40 pm | Jeffrey Kroon (Sanquin Research, The Netherlands)
"The Rho-GEF Trio Regulates Angiogenic Sprouting
Through VE-Cadherin" |
| 8:40 pm - 8:45 pm | Discussion |
| 8:45 pm - 8:55 pm | Barbara Lavina Siemsen (Uppsala University, Sweden)
"Role of Cdc42 in Sprouting Angiogenesis" |
| 8:55 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:10 pm | Mark Richards (University of Bristol, United Kingdom)
"RhoJ and FMNL3 Mediate Endothelial Apical Specification and Membrane Trafficking" |
| 9:10 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:25 pm | Anne Karine Lagendijk (Institute for Molecular Biology, University of Queensland, Australia)
"Live Imaging of Intra-Molecular Tension Through Zebrafish VE-Cadherin Uncovers Mechanical Contributions in Artery Maturation and Cavernous Malformation" |
| 9:25 pm - 9:30 pm | Discussion |
| Sunday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 11:00 am | Mechanisms Regulating Vessel Morphogenesis in Development and Disease |
| Discussion Leaders: William Schachterle (Weill Cornell Medical College, USA) and Claudia Prahst (Beth Israel Deaconess Medical Center, USA) |
| 9:00 am - 9:10 am | Martin Kragl (Heinrich-Heine University Düsseldorf, Germany)
"Requirement of Endocrine Cell Adhesivity for Blood Vessel Maintenance Within Pancreatic Islets" |
| 9:10 am - 9:15 am | Discussion |
| 9:15 am - 9:25 am | Raphael Reuten (Medical Faculty University of Cologne, Germany)
"Netrin-4 Regulates Functional Vascular Basement Membrane Assembly and Neo-Angiogenic Events" |
| 9:25 am - 9:30 am | Discussion |
| 9:30 am - 9:40 am | Alexandre Dubrac (Yale University, USA)
"Targeting NCK-Mediated Endothelial Cell Front-Rear Polarity Inhibits Retinal Neo-Vascularization" |
| 9:40 am - 9:45 am | Discussion |
| 9:45 am - 9:55 am | Emma Gordon (Uppsala University, Sweden)
"Investigating the Link Between TSAd, Src and Actin Organisation in Vascular Permeability and Angiogenesis" |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am - 10:10 am | Kerstin Wilhelm (Max Planck Institute for Heart and Lung Research, Germany)
"FOXO1 Couples Metabolic Activity and Growth State in the Vascular Endothelium" |
| 10:10 am - 10:15 am | Discussion |
| 10:15 am - 10:25 am | Minah Kim (University of California, San Francisco, USA)
"Differential Action of
Angiopoietin-2 on Tie2 Signaling in the Presence or Absence of Inflammation" |
| 10:25 am - 10:30 am | Discussion |
| 10:30 am - 10:40 am | Thomas Wälchli (Neuroscience Center Zurich / Swiss Center for Regenerative Medicine, Switzerland)
"Nogo-A and S1PR2 as Novel Regulators of Developmental and Tumor Angiogenesis in the CNS" |
| 10:40 am - 10:45 am | Discussion |
| 10:45 am - 10:55 am | Noemi Rudini (IFOM-FIRC Institute of Molecular Oncology, Italy)
"KLF4 Is a Key Determinant of Developmental and Progression of Cerebral Cavernous Malformations" |
| 10:55 am - 11:00 am | Discussion |
| 11:00 am - 12:30 pm | Poster Session |
| Coffee will be served in the poster area from 11:00 am - 11:30 am |
| 12:30 pm | Lunch |
| 1:30 pm - 2:30 pm | Influence of Force on Vessel Architecture |
| Discussion Leader: Heinz-Georg Belting (Biozentrum, University of Basel, Switzerland) |
| 1:30 pm - 1:40 pm | Jing Li (University of Leeds, United Kingdom)
"Key Role of Endothelial Piezo1 in Vascular Development" |
| 1:40 pm - 1:45 pm | Discussion |
| 1:45 pm - 1:55 pm | Hiroyuki Nakajima (National Cerebral and Cardiovascular Center Research Institute, Japan)
"Flow-Dependent Mechanical Stress Induces Nuclear Translocation of YAP1 by Regulating Actin Cytoskeleton" |
| 1:55 pm - 2:00 pm | Discussion |
| 2:00 pm - 2:20 pm | Julien Vermot (Institute of Genetics and Molecular and Cellular Biology, France)
"Mechanical Forces and Blood Flow Sensing in Developing Blood Vessels" |
| 2:20 pm - 2:30 pm | Discussion |
| 2:30 pm - 3:00 pm | Evaluation Period |
| Fill in GRS Evaluation Forms |
| 3:00 pm | Seminar Concludes |
