Sunday, April 20: 7:30 - 10:00 pm
Phylogenesis of the renin system
Discussion Leader: D. Coates
- H. Nishimura - Phylogeny of angiotensin receptors and signaling
- N. Hazon - RAS in elasmobranches
- M. Salzet - Renin and angiotensin converting enzyme in the Annelids
- E. Isaac - Insect angiotensin-converting enzyme: Comparative biochemistry and evolution
Discussants: A. Shirras, T. Williams
Monday, April 21: 9:30 am - 12:30 pm
G-protein coupling / Angiotensin coupling
Discussion Leader: P. Delafontaine
- F. McKenzie - Vaso-active peptides and MAP kinases
- L. M. Luttrell - Regulation of tyrosine protein phosphorylation by G protein-coupled receptors
- B. Berk - Angiotensin II signal transduction: Role of tyrosine-kinase
Discussants: N. Gallo-Payet, E. Escher, S. Karnik, C. Nahmias
Monday April 21: 4:30 - 7:30 pm
Angiotensin and CNS
Discussion Leader: F. A. O. Mendelsohn
- C. Llorens-Cortes - The role of aminopeptidase A in the metabolism of angiotensin in the brain
- M. Raizada - The AT1 receptor and neuromodulation
- M. McKinley - Central angiotensinergic pathways involved in the neural and endocrine regulation of the kidneys
Discussants: J. M. Saavedra, Ch. Gelband, M. I. Phillips, K. Sandberg
Tuesday, April 22: 9:30 am - 12:30 pm
Protein processing in health and diseases
Discussion Leader: I. Sen
- J. Arribas - A common mechanism governing the shedding of transmembrane proteins
- R. A. Black - TNFalpha converting enzyme: Proteolytic processing of a cell-surface protein by a mammalian adamalysin
- S. E. Gandy - Metabolism of the Alzheimer ß-amyloid precursor protein (ßAPB): Protein phosphorylation regulated ßAPP transport vesicle biogenesis in the TGN
- T. L. Reudelhuber - Intracellular targeting and proteolytic activation of human prorenin
Discussant: S. Danilov
Tuesday, April 22: 4:30 - 7:30 pm
Endothelin
Discussion Leader: M. Clozel
- M. Yanagisawa - Endothelin: Vascular biology to genetics
- H. Kurihara - Gene targeting and overexpression of ET-1 in mice
- T. F. Luetscher - Endothelin receptor blockade from experimental models to patients with cardiovascular diseases
Discussants: O. Valdenaire, F. Pinet
Wednesday, April 23: 9:30 am - 12:30 pm
Interactions of the renin-angiotensin system and the arginine/NO system
Discussion Leader: D. G. Harrisson
- G. Gibbons - Antagonistic roles of nitric oxide and angiotensin II in vascular remodeling and lesion formation: A matter of life and death
- E. Shesley - Altered blood pressures and renin concentration in mice lacking endothelial nitric oxide synthase
- T. Hintze - Interaction of angiotensin and bradykinin in the control of NO production and tissue oxygen consumption
Discussants: T. Munzel, K. Griendling, O. Carretero
Thursday, April 24: 9:330 am - 12:30 pm
Genetics
Discussion Leader: F. Soubrier
- J. Rapp - Rat hereditary hypertension: Towards gene identification
- J. Naggert - Experimental genetics in metabolic syndromes of the mouse
- J. Krege - Mutating genes to study hypertension
- L. Pascoe -Inherited disoders of steroid biosynthesis and hypertension caused by mutations in CYP11B genes
Discussants: J-B. Michel, M. Paul, H. Montgomery
Thursday, April 24: 4:30 - 7:30 pm
Steroids and blood pressure regulation
Discussion Leader: A. Capponi
- T. Balla - Novel elements of the inositide/calcium signaling pathway involved in AT1 receptor-mediated cellular responses
- N. Cherradi - Mitochondrial sites of action of calcium in the acute regulation of mineralocorticoid biosynthesis by angiotensin II
- A. Agarwal - Mutations in 11ß-hydroxysteroid deshydrogenase (type II) gene as a cause of hypertension
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