Sunday Afternoon: Arrival and Registration
Sunday, March 11 Session 1: | Proteomics/Genomics and the renin angiotensin system |
Discussion leader: Victor Dzau, Harvard Medical School, Brigham and Women's Hospital, Boston, MA USA
- C.C. Liew, Brigham and Women's Hospital
"Overview - From EST to Quantitative Genomics: Current Perspectives in
Cardiovascular Medicine"
- Richard Lawn, CV Therapeutics, Palo Alto, CA USA
"Discovery of cardiovascular targets using microarray technology:
Macrophoge & HDL pathways"
- Bruce Conklin, Gladstone Institute, San Francisco, CA USA
"Genomic responses to signaling of engineered receptors and G protein in
vivo"
- Richard Pratt, Brigham and Women's Hospital, Boston, MA
"Signaling and physiological effect of AT2 receptor"
- Panel discussion on Techniques and Bioinformatics
Monday, March 12 Session 2: | AT1R signal transduction: Intracellular pathways |
Discussion leader: R. Wayne Alexander, Emory University School of Medicine, Atlanta, GA USA "Overview"
- Jojo Haendeler, Germany
"Git-1: A molecular switch that control angiotensin II signal transduction"
- Peter Sayeski, University of Florida, Gainesville, FL
"JAK STAT in AngII Signaling"
- Tadeshi Inagami, University of Vanderbilt, Nashville, TN
"SHP-2 in AngII signaling"
- Pam Lucchesi, University of Alabama at Birmingham, Birmingham, AL
"PYKing your way from the AT1 receptor to vascular smooth muscle cell growth"
Monday, March 12 Session 3: | AT1R signal transduction: Oxidative stress |
Discussion leader: Kathy Griendling, Emory University, Atlanta, GA USA "Introduction/Update"
- Darren Richard, Centre de Recherche, CHUQA, Quebec, Canada,
"Vasoactive hormones and hypoxia in the control of vascular endothelial growth factor"
- Masuko Ushio-Fukai, Emory University, Atlanta, GA
"Mechanisms of angiotensin II-induced angiogenesis: role of oxidant stress"
- Christopher Wilcox, Georgetown University Medical Center, Washington, DC
"Angiotensin II-induced oxidative stress and nephron hypoxia in hypertensive kidney"
- Ernesto Schiffrin, Institut de recherches cliniques de Montreal, Quebec CANADA
"Superoxide generation in resistance vessels from normotensive and hypertensive patients"
Monday, March 12 Session 4: | Vascular remodeling and the renin angiotensin system |
Discussion leader: Ernesto Schiffrin, Institut de recherches cliniques de Montreal, Quebec CANADA
- Volkhard Lindner, Maine Medical Center Research Institute, South Portland, ME
"Genetic aspects of vascular remodeling in mice"
- Andrew Greene, Medical College of Wisconsin, Milwaukee, WI
"Microvascular angiogenesis - an essential role for the renin-angiotensin system"
- Joseph deMey, Maastricht, Holland
"Interactions of angiotensin and cytoskeleton in vascular remodeling"
- W. Robert Taylor, Emory University, Atlanta, GA
"Angiotensin II and atherosclerosis, mechanistic insights"
Tuesday, March 13 Session 5: | Type 2 Angiotensin II receptor (AT2R) signal transduction and biology |
Discussion leader: Mohan Raizada, University of Florida, Gainesville, FL USA
- Colin Sumners, University of Florida, Gainesville, FL
"AT2-AS Gene transfer"
- Robert Carey, University of Virginia Health Sciences Center, Charlottesville, VA
"Expression and functional significance of AT2 receptor in the periphery"
- Helmy Siragy, University of Virginia Health Sciences Center, Charlottesville, VA
"AT2 receptor and renal function"
- Sadashiva Karnik, The Cleveland Clinic Foundation, Cleveland, OH
"Ligand independent signaling from AT2 receptor"
Tuesday, March 13 Session 6: | Lessons regarding the renin angiotensin system from transgenic experiments |
Discussion leader: Kenneth Bernstein, Emory University, Atlanta, GA USA
- Kirk Thomas, Howard Hughes Medical Institute, Salt Lake City, Utah
"New strategies in genetic targeting: designing knockout mice in the 21st century"
- Curt Sigmund, University of Iowa, Iowa City, IA
"Organ specific knockout of the renin-angiotensin system"
- Tom Coffmann, Duke University Medical Center, Durham, NC
"The biology of the AT1 receptor explored using knockout mice"
- Justin Cole, Emory University, Atlanta GA
"Selective knockout of angiotensin converting enzyme"
Tuesday, March 13 Session 7: | Cardiac renin angiotensin system |
Discussion leader: Kenneth M. Baker, Texas A&M University Health Science Center, Temple, TX USA "Session Overview"
- Mona Nemer, University of Montreal, IRCM
"Targeted overexpression of AT1 in mouse heart"
- Walter Thomas, Baker Medical Research Institute, Melbourne, Australia
"Adenoviral mediated overexpression of AT1 in rat cardiac myocytes and fibroblasts"
- Keichi Fukada, Keio University School of Medicine, Tokyo, Japan
"Role of AT1 JAK/STAT interactions in stretch mediated cardiomyocyte growth"
- Hiroaki Matsubara, Kansai Medical University, Osaka, Japan
"Cardiac AT2 function unmasked by cardiomyocyte or SMC targeted overexpression in mice"
Wednesday, March 14 Session 8: | Vascular renin angiotensin system |
Discussion leader: Douglas E. Vaughan, Vanderbilt University Medical Center, Nashville, TN USA "Angiotensin and PAI-1"
- Alan Daugherty, University of Kentucky, Lexington, KY
"Angiotensin and Atherosclerosis"
- Nancy J. Brown, Vanderbilt University School of Medicine, Nashville, TN
"Bradykinin metabolism and mechanisms of t-PA release"
- J.L. Mehta, University of Arkansas for Medical Sciences, Little Rock, AR
"Angiotensin and the LOX receptor"
Wednesday, March 14 Session 9: | Intrarenal angiotensin: generation, regulation and action |
Discussion leader: Willa A. Hsueh, Division of Endocrinology, Diabetes and Hypertension, University of California, Los Angeles, CA USA
- Wayne Border, University of Utah, Salt Lake City, UT
"TGF-beta: a critical factor in tissue fibrosis"
- Susanne Nicholas, University of California, LA
"Angiotensin II, PPAR-gamma and PAI-1 the mesangium in diabetes"
- Agnes Fogo, Vanderbilt University, Nashville, TN
"Angiotensin and PAI-1 potential targets for regression of sclerosis"
- Christine Maric, University of Melbourne, Australia
"Osmotic regulation of angiotensin receptors in the renal medulla"
Wednesday, March 14 Session 10: | Angiotensin II & aldosterone: adrenal gland and heart |
Discussion leader: Alessandro M. Capponi, Division of Endocrinology and Diabetology, University Hospital, Geneva SWITZERLAND "Angiotensin II modulates StAR protein and HDL-receptor (SR-BI) expression in ardenal cortex and heart"
- Claude DelCayre, INSERM, Hopital Lariboisiere, Paris France
"Interactions of cardiac tissular aldosterone and angiotensin II and their role in cardiac remodeling"
- Kathleen Kayes-Wandover, University of Texas Southwestern Medical Center, Dallas, TX
"Aldosterone and the human heart"
- Annette Fiebeler, Franz Volhard Clinic, Berlin, Germany
"Role of the mineralocorticoid receptor in the mediation of Ang II-induced vascular injury"
Thursday, March 15 Session 11: | The role of sex in the renin angiotensin system |
Discussion leader: Kathryn Sandberg, Departments of Medicine & Physiology, Georgetown University Medical Center, Washington, DC, USA
- Darren Roesch, Georgetown University, Washington, DC
"Could an ovarian influence rejuvenate a troubled kidney? New thoughts on estrogens and adrenal and renal responsiveness to angiotensin"
- Steven Fluharty, University of Pennsylvania, Philadelphia, PA
"Estrogen regulation of the central actions of Ang II"
- Bridget Brosnihan, Wake Forest
"Bidirectional actions of estrogen on the renin angiotensin system"
Thursday, March 15 Session 12: | Inhibitors of the RAS and Cardiovascular Disease Progression |
Discussion leader: Jay N. Cohn, University of Minnesota,
Cardiovascular Division, Minneapolis, MN USA
"Val-HeFT"
- Suzanne Oparil, University of Alabama, Birmingham, AL
"Human RAS"
- Bertram Pitt, University of Michigan Health Sytem, Ann Arbor, MI
"ELITE I & II"
- Bjorn Dahlof, Ostra Hospital, University of Goteborg, Goteborg, Sweden
"LIFE"
- Peter Sleight, Cardiovascular Medicine Department, John Radcliffe Hospital, Oxford, UK
"HOPE"
Thursday, March 15 Session 13: | Keynote lecture: renin angiotensin system and genomics |
Discussion Leader: Bradford C. Berk, University of Rochester, Rochester, NY USA
- Pierre Corvol, College de France, Paris, France
"Vasoactive peptides and angiogenesis"
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