| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| 4:00 pm - 6:00 pm | Reception |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | AT1 Receptor Structure and Function |
| Session Overview: Walter Thomas (Baker Medical Research Institute, Victoria, Australia) |
| Emanuel Escher (Universite de Sherbrooke, Sherbrooke, Quebec, Canada)
Structural Aspects of Angiotensin II Binding and Receptor Activation |
| Sadashiva Karnik (Cleveland Clinic, Cleveland, OH)
AT1 Receptor Activation - The Movie |
| Junichi Sadoshima (University of Medicine and Dentistry of New Jersey, Newark, NJ)
The Role of Heterotrimeric G protein and EGFR Coupling in Angiotensin II-induced Hypertrophy and Apoptosis in the Mouse Heart |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Photo |
| 9:00 am - 12:30 pm | Molecular Signaling of Angiotensin Receptors |
| Session Overview: Eric Clauser (Institut Cochin, Paris, France) |
| Kevin J. Catt (NICHD, NIH, Bethesda, MD)
Interactions and Signaling Between GPCRs and RTKs |
| Walter G. Thomas (Baker Medical Research Institute, Melbourne, Australia)
AT1 Signaling via EGFR Transactivation |
| Discussant: Satoru Eguchi (Temple University,
Philadelphia, PA)
Vascular Tyrosine Kinase Network Activated by the AT1 |
| 10:30 am | Coffee Break |
| Angiotensin Receptor Trafficking and Function of Signaling Complexes |
| Session Overview: Laszlo Hunyady (Semmelweis University, Budapest, Hungary) |
| Luis M. Luttrell (Duke University Medical Center, Durham, NC)
Role of Signaling Complexes in Angiotensin Growth Control |
| Stephen S. G. Ferguson (University of Western Ontario, London, Ontario, Canada)
Regulation of Angiotensin II Type 1A Receptor Endocytosis and Trafficking by Small G Proteins |
| Tamas Balla (NICHD, Bethesda, MD)
The Role of Inositol Lipids in the Formation of Signaling Complexes and in GPCR Trafficking |
| 12:30 pm | Lunch |
| 4:00 pm - 6:00 pm | Poster Session and Reception |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Genetics and Animal Models |
| Session Overview: Curt D. Sigmund (University of Iowa, Iowa City, IA) |
| Mansoor Husain (University of Toronto, Toronto, Ontario, Canada)
Tissue-specific Conditional Gene Expression: A Tool Enabling Unique Models of Cardiovascular Disease? |
| Scott Heximer (University of Toronto, Toronto, Ontario, Canada)
Please Mind the GAP -defining the role of RGS2 as a modulator of the renin-angiotensin system |
| Young
Investigator Award Competition |
| Nicola J. Smith (University of Melbourne, Melbourne, AU)
Angiotensin II Receptor Transactivation of the EGF Receptor: Role of G
Protein Coupling and Metalloprotease Activation in Cardiac Hypertrophy |
| Mizuo Mifune (Temple University School of Medicine, Philadelphia, PA)
EGF Receptor Transactivation-independent Rho/Rho Kinase Activation
Mediates ANG II-induced JNK Activation and Migration in VSMCs |
| Yoshihiro Taniyama (Emory University School of Medicine, Atlanta, GA)
Reactive Oxygen Species- and PDK-1-dependent Downregulation of IRS-1 by
Angiotensin II as a Cause of Insulin Resistance |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Cardiovascular Genomics |
| Session Overview: TBA |
| Richard E. Pratt (Brigham and Women's Hospital, Boston, MA)
Physiological Genomics: High Throughput Strategies to Identify Genes Mediating RAS Effects |
| Mark Caulfield (Barts and the London School of Medicine and Dentistry, London, UK)
Genome Scans and Beyond in Complex Cardiovascular Traits |
| Young Investigator Award Competition |
| Hong D Xiao (Emory University School of Medicine, Atlanta, GA)
Mice with Cardiac Restricted Angiotensin Converting Enzyme Have Atrial
Enlargement, Cardiac Arrhythmia and Sudden Death |
| Katia Savary (College de France, Paris, France)
Ontogeny and Possible Role of Angiotensin-converting Enzyme in Blood
Islands Differentiation |
| Rajesh Kumar (Texas A&M University College of Medicine, Temple, TX)
Evidence of a Novel Intracrine Mechanism in Angiotensin II-induced
Cardiac Hypertrophy |
| 10:30 am | Coffee Break |
| Posttranscriptional Regulation of AT Receptors |
| Session Overview: Georg Nickenig (University of Saarland, Hombourg, Germany) |
| Gary Brewer (University of Medicine and Dentistry of New Jersey, Piscataway, NJ)
Contributions of Posttranscriptional Controls to Gene Expression |
| Kathryn Sandberg (Georgetown University, Washington, DC)
Posttranscriptional Regulation of Angiotensin Receptors via Alternative Splicing |
| Thomas J. Thekkumkara (Texas Tech University, Amarillo, TX)
Posttranscriptional Regulation of AT1 Receptor: Is There a Role for mRNA Binding Proteins? |
| 12:30 pm | Lunch |
| 4:00 pm - 6:00 pm | Poster Session and Reception |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Novel Aspects of AT2 Receptor Function |
| Session Overview: Sadashiva Karnik (Lerner Research Institute, Cleveland, OH) |
| Clara Nahmias (Institut Cochin, Paris, France)
Novel AT2 Receptor Interacting Proteins Involved in Growth Inhibition |
| Anand K. Srivastava (J.C. Self Research Institute of Human Genetics, Greenwood, SC)
AT2 Receptor and Human Cognitive Function |
| Louis Gendron (Montreal Neurological Institute, Mc Gill
University, Montreal, Quebec, Canada)
Novel Aspects of AT2 Receptor Signaling Involved in Neurite Outgrowth |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Ang III and Ang IV - Novel Findings and Surprises |
| Session Overview: Frederick Mendelsohn (Howard Florey Institute, Melbourne, Australia) |
| Siew Yeen Chai (The University of Melbourne, Victoria, Australia)
Roles of AT4 Receptor / Insulin-Regulated Aminopeptidase in the CNS |
| Susanna R Keller (University of Virginia, Charlottesville, VA)
Physiological Functions of the Insulin-Regulated Aminopeptidase IRAP |
| Catherine Llorens-Cortes (College de France, Paris, France)
Central Actions of Ang III in Hypertension |
| Discussant: Genevieve Nguyen (College
de France, Paris, France)
Mutation of the Renin Receptor is Associated with the Absence of ERK1/2 Activation in a Family with X-Linked Mental
Retardation and Epilepsy |
| 10:30 am | Coffee Break |
| Angiotensin & Atherosclerosis |
| Session Overview: W. Robert Taylor (Emory University School of Medicine, Atlanta, GA) |
| Pascal Goldschmidt (Duke University School of Medicine, Durham, NC)
Atherosclerosis: Central Instead of Peripheral Hypothesis |
| Nobuyo N. Maeda (University of North Carolina, Chapel Hill, NC)
Blood Pressure Effects on Atherosclerosis in Mouse Models |
| Lisa L. Cassis (College of Pharmacy, University of Kentucky, Lexington, KY)
Mechanisms of Angiotensin II-Induced Atherosclerosis and Aneurysm
Formation |
| Neal L. Weintraub (University of Iowa College of Medicine, Iowa City, IA)
Role of Oxidative Stress in Abdominal Aortic Aneurysm Formation Induced
by Angiotensin II |
| 12:30 pm | Lunch |
| 4:00 pm - 6:00 pm | Reception |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Development and Plasticity of Renin-Expressing Cells |
| Session Overview: Ariel Gomez (University of Virginia, Charlottesville, VA) |
| Maria Luisa Sequeira Lopez (University of Virginia, Charlottesville, VA)
Studies on lineage and differentiation of renin-expressing cells |
| Victor Dzau (Harvard Medical School, Boston, MA)
Role of LXRalpha on Renin Transcription and Development |
| Kenneth Gross (Roswell Park Cancer Institute, Buffalo, NY)
Insights on renin from zebrafish |
| Josie Briggs (NIDDK, NIH, Bethesda, MD)
Macula Densa Control of Renin Relaese- Potential Pathways |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Local Angiotensin Generation: Angiotensin II in Different Organs |
| Session Overview: Juerg Nussberger (Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland) |
| Jan Danser (Erasmus Medical Center, Rotterdam, The Netherlands)
The Site of Angiotensin II Generation: Intra- or Extracellular? |
| Lucia Mazzolai (CHUV, Lausanne, Switzerland)
Angiotensin II and the Vascular System |
| Hans Imboden (Institute of Cell Biology, University of Bern, Bern, Switzerland)
Mapping of Angiotensin II and Angiotensin II Receptor Subtypes in the Central Nervous System: A Critical View |
| 10:30 am | Coffee Break |
| Impacts of Aldosterone on Cardiovascular Disease |
| Session Overview: Gail Adler (Brigham and Women's Hospital, Boston, MA) |
| David Pearce (University of California, San Francisco, CA)
Basic Physiology of Mineralocorticoid Receptor Action |
| Ricardo Rocha (Novartis Pharmaceutical Corp., East Hanover,
New Jersey)
Pathophysiologic Mechanisms for Aldosterone-induced Hypertension and End-organ Damage |
| Gail Adler (Brigham and Women's Hospital, Boston, MA)
Animal Models of Aldosterone Induced Cardiovascular Injury |
| 12:30 pm | Lunch |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Awards Session |
| |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |
