Sunday |
4:00 pm - 8:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Keynote Session: Regulation and Genetics of the Renin-Angiotensin-Aldosterone System |
| Discussion Leader: Curt Sigmund (University of Iowa, USA) |
7:40 pm - 7:50 pm | Opening Remarks |
7:50 pm - 8:30 pm | Armin Kurtz (University of Regensburg, Germany) "Regulation of Renin Expression
and Secretion in the Kidney, Modes and Mechanism" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:20 pm | Xavier Jeunemaitre (Paris Descartes University, France) "Molecular Genetics and Pathways Involved in Patients with Low Renin and Pseudo-Aldosteronism" |
9:20 pm - 9:30 pm | Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Renin Angiotensin Aldosterone Blockers: Are Dual Specificity Inhibitors the Next Great Thing? |
| Discussion Leaders: Rhian Touyz (University of Glasgow, United Kingdom) and Jan Danser (Erasmus MC, The Netherlands) |
9:00 am - 9:10 am | Introduction by Discussion Leader |
9:10 am - 9:40 am | John McMurray (University of Glasgow, United Kingdom) "Angiotensin Receptor Neprilysin Inhibition – The New Paradigm" |
9:40 am - 9:50 am | Discussion |
9:50 am - 10:10 am | Lodi Roksnoer (Erasmus MC, The Netherlands) "Reno and Cardioprotective Effects of Dual AT1 Receptor-Neprilysin Inhibitors" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:45 am | Coffee Break |
10:45 am - 11:00 am | Oliver Domenig (Medical University of Vienna, Austria) "Comprehensive Biochemical Evaluation of the Renin-Angiotensin-System" |
11:00 am - 11:05 am | Discussion |
11:05 am - 11:20 am | Fumitoshi Satoh (Tohoku University Graduate School of Medicine, Japan) "Novel Very Rapid Measurements of Active Renin and Aldosterone Concentrations and Its Clinical Significance for the Selection of Antihypertensive Agents" |
11:20 am - 11:25 am | Discussion |
| Young Investigator Presentations |
11:25 am - 11:30 am | Introduction by Discussion Leader |
11:30 am - 11:40 am | Douglas Bennion (University of Florida, USA) "Human Serum ACE2 Activity in Ischemic Stroke: A Moving Target for Translational Treatments" |
11:40 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Katrina Binger (Baker IDI Heart and Diabetes Institute, Australia) "Conditional Deletion of the (Pro)Renin Receptor Leads to Disturbed Pancreatic Beta-Cell Homeostasis and the Onset of Severe Diabetes" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Kristin Claflin (University of Iowa, USA) "Control of Resting Metabolic Rate by Angiotensin AT1A Receptors in Leptin-Sensitive Cells" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Johannes Kovarik (Medical University of Vienna, Austria) "Rise of Chymase Dependent Ang II Formation After Kidney Transplantation" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
3:00 pm - 4:00 pm | Power Hour |
| The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring. |
| Organizers: Lisa Cassis (University of Kentucky, USA) and Rhian Touyz (University of Glasgow, United Kingdom) |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm - 8:00 pm | Regulatory Networks and Clinical Relevance |
| Discussion Leader: Akira Nishiyama (Kagawa University Medical School, Japan) |
6:00 pm - 6:25 pm | Rhian Touyz (University of Glasgow, United Kingdom) "Chanzymes in Vascular Biology" |
6:25 pm - 6:35 pm | Discussion |
6:35 pm - 7:00 pm | Youhua Liu (University of Pittsburgh School of Medicine, USA) "Wnt/β-Catenin Signaling and Renin Angiotensin System" |
7:00 pm - 7:10 pm | Discussion |
7:10 pm - 7:20 pm | Maira Soto (University of Southern California, USA) "Modifying the Renin-Angiotensin System to Improve Pulmonary Health in Type 2 Diabetes" |
7:20 pm - 7:25 pm | Discussion |
7:25 pm - 7:50 pm | Adam Mullick (Ionis Pharmaceuticals, USA) "LICA-Antisense Oligonucleotide Inhibition of Angiotensinogen: A New Therapeutic Approach for Treatment-Resistant Hypertension" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm | Dinner |
Tuesday |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | New Roles for Renin, Renin Receptor and ACE in the Kidney |
| Discussion Leaders: Thomas Coffman (Duke-NUS Medical School, Singapore) and Rodrigo Fraga-Silva (Wyss Center for Bio and Neuroengineering, Switzerland) |
9:00 am - 9:25 am | Maria Louisa Sequiera-Lopez (University of Virginia, USA) "Renin Cell Progenitors in Development and Disease" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Jorge Giani (Cedars-Sinai Medical Center, USA) "Renal Tubular Epithelial ACE Is Obligatory for Experimental Hypertension" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:20 am | Johannes Stegbauer (Heinrich Heine University Düsseldorf, Germany) "Ciliary Neurotrophic Factor Deficiency Protects Against Angiotensin II-Dependent Hypertension and Hypertensive End Organ Damage" |
10:20 am - 10:25 am | Discussion |
10:25 am - 10:50 am | Coffee Break |
10:50 am - 11:15 am | Minolfa Prieto-Carrasquero (Tulane University, USA) "Consequences of the Functional Role in the Prorenin Receptor in the Collecting Duct" |
11:15 am - 11:25 am | Discussion |
| Selected Presentations from the GRS |
11:25 am - 11:30 am | Introduction by Discussion Leader |
11:30 am - 11:45 am | Dane Jensen (University of Nevada, Reno, USA) "Epigenetic Regulation of Brain (Pro)Renin Receptor by Epithelial Sodium Channel in DOCA-Salt Hypertension" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Nicole Littlejohn (University of Iowa, USA) "Suppression of Resting Metabolic Rate by the Angiotensin AT2 Receptor" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Antonio Peluso (University of Southern Denmark, Denmark) "AT2-Receptor Stimulation Promotes NO Release Through eNOS Serine1177 Phosphorylation and eNOS Tyrosine657 Dephosphorylation" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm - 8:00 pm | Immunity, Inflammation and AT1 Receptors |
| Discussion Leader: Ulrich Wenzel (University Medical Center Hamburg-Eppendorf, Germany) |
6:00 pm - 6:25 pm | Steven Crowley (Duke University Medical Center, USA) "A Role for Inflammatory Cytokines in the Pathogenesis of Hypertension" |
6:25 pm - 6:35 pm | Discussion |
6:35 pm - 7:00 pm | Daniela Carnevale (Neuromed Insitute for Neurosciences, Sapienza University of Rome, Italy) "Neuroimmune Interactions in Hypertension" |
7:00 pm - 7:10 pm | Discussion |
7:10 pm - 7:20 pm | Hamiyet Unal (Erciyes University, Turkey) "Novel Function of RGS2 as a Transcriptional Repressor of STAT3 in Regulating Gene Expression Involved in AngII-Induced Pathogenesis" |
7:20 pm - 7:25 pm | Discussion |
7:25 pm - 7:50 pm | Duska Dragun (Charité - Universitätsmedizin Berlin, Germany) "Structural and Functional Consequences of Antibody Mediated AT1R Activation" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm | Dinner |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | The Brain RAS |
| Discussion Leaders: Eric Lazartigues (LSU Health Sciences Center New Orleans, USA) and Dominik Muller (Experimental and Clinical Research Center, Max Delbrück Center for Molecular Medicine, Germany) |
9:00 am - 9:25 am | Yumei Feng (University of Nevada, USA) "Neuronal (Pro)Renin Receptor in High-Fat Diet Induced Diabetes and Obesity" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Javier Stern (Georgia Regents University, USA) "Novel Insights into Central Mechanistic Targets Mediating AngII Actions in the Brain" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:20 am | Keisuke Shinohara (University of Iowa, USA) "Selective Deletion of Intracellular Renin in the Brain Causes Hypertension and Elevated Sympathetic Nervous System Activity" |
10:20 am - 10:25 am | Discussion |
10:25 am - 10:55 am | Coffee Break |
| Salt and Metabolism |
10:55 am - 11:20 am | Jens Titze (Vanderbilt University, USA) "Salt Metabolism: From Volume Control to Biological Barrier Formation" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Jonathan Jantsch (University of Regensburg, Germany) "Salt Storage Creates Biological Barrier to Ward Off Infection" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Frederique Yannikouris (University of Kentucky, USA) "Adipocyte PRR, a New Target to Prevent Obesity-Hypertension?" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm - 8:00 pm | Technical
Advances in Optogenetics/Chemogenetics and Applications to Ang-II and Its Neural Circuits |
| Discussion Leader: Mingyu Liang (Medical College of Wisconsin, USA) |
6:00 pm - 6:25 pm | Sergey Kasparov (University of Bristol, United Kingdom) "An Overview of Current Optogenetic Actuators and Reporters" |
6:25 pm - 6:35 pm | Discussion |
6:35 pm - 7:00 pm | Eric Krause (Univerisity of Florida, USA) "Optogenetic Dissection of 'Angiotensin Sensitive' Brain Circuits: Implications for Mental and Cardiovascular Health" |
7:00 pm - 7:10 pm | Discussion |
7:10 pm - 7:20 pm | Colin Sumners (University of Florida, USA) "Hindbrain Angiotensin Type 2 Receptors and Hypertension" |
7:20 pm - 7:25 pm | Discussion |
7:25 pm - 7:50 pm | Kamal Rahmouni (University of Iowa, USA) "Opto- and Chemo-Genetic Mediated Modulation of POMC and AGRP Neurons" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm | Dinner |
Thursday |
7:30 am - 8:30 am | Breakfast |
8:30 am - 9:00 am | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
9:00 am - 12:30 pm | Recent Advances in the RAS |
| Discussion Leaders: Toshiro Fujita (The University of Tokyo, Japan) and Lisa Cassis (University of Kentucky, USA) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:30 am | Mark Chappell (Wake Forest University, USA) "An Intracellular Angiotensin-(1-7) System" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Katie Hood (University of Glasgow, United Kingdom) "The Ang-(1-7)-ET-1 Axis – A New Partnership" |
10:05 am - 10:15 am | Discussion |
10:15 am - 10:45 am | Coffee Break |
10:45 am - 11:10 am | Shigeru Shibata (University of Tokyo / Teikyo University, Japan) "Uncovering Pathways Downstream of Angiotensin II Signaling in the Distal Nephron of the Kidney" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:45 am | Sadashiva Karnik (Cleveland Clinic, USA) "Molecular Recognition and Functional Selectivity Mechanisms of Angiotensin II Type 1 Receptor Blocking Drugs" |
11:45 am - 11:55 am | Discussion |
11:55 am - 12:20 pm | Kenneth Gross (Roswell Park Cancer Institute, USA) "Renin-Expressing Cell Lineage and Progenitor Cell Function During Pancreatic Neuroendocrine Differentiation and Development" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm - 8:00 pm | Genome and Editing and MicroRNAs |
| Discussion Leader: Michael Bader (Max Delbrück Center for Molecular Medicine, Germany) |
6:00 pm - 6:25 pm | Michael Bader (Max Delbrück Center for Molecular Medicine, Germany) "Novel Transgenic Technologies for the Functional Analysis of the RAS" |
6:25 pm - 6:35 pm | Discussion |
6:35 pm - 7:00 pm | Mingyu Liang (Medical College of Wisconsin, USA) "MicroRNAs in Hypertension: From Cells to Human Subjects" |
7:00 pm - 7:10 pm | Discussion |
7:10 pm - 7:20 pm | Yu Wang (University of Newcastle, Australia) "Role of hsa-miR-181a in Regulating Human Placental Renin Expression and Prorenin Protein" |
7:20 pm - 7:25 pm | Discussion |
7:25 pm - 7:50 pm | Andrew Baker (University of Edinburgh, United Kingdom) "miRNA Regulation and Function During Vascular Remodelling" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm | Dinner |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |