Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Paradigm Shifts in the RAAS
Keynote lectures by Dr. Ariel Gomez and Dr. David Harrison.
Discussion Leader: Toshiro Fujita (The University of Tokyo, Japan)
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:30 pm
Ariel Gomez (University of Virginia, USA)
"Control of Renin Cell Identity in Homeostasis and Disease"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
David Harrison (Vanderbilt University Medical Center, USA)
"Insights into the Role of RAS and Other Hypertensive Stimuli in Immune Activation"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Additional RAS Signaling Mechanisms / Novel Functions of Renin Cells
Discussion Leaders: Satoru Eguchi (Temple University School of Medicine, USA), Maria Luisa Sequeira-Lopez (University of Virginia, USA) and Ulrike Steckelings (University of Southern Denmark, Denmark)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Michal Schwartzman (New York Medical College, USA)
"20-HETE-RAS Interactions in Hypertension"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Motohiro Nishida (National Institutes of Natural Sciences, Japan)
"Cardiovascular Ageing Regulated by Heterodimerization of Angiotensin AT1 Receptor with Purinergic P2Y6 Receptor"
10:00 am - 10:10 am
Discussion
10:10 am - 10:35 am
Coffee Break
10:35 am - 10:40 am
Introduction by Discussion Leader
10:40 am - 11:05 am
Christian Hugo (University Hospital Carl Gustav Carus Dresden, Germany)
"The Juxtaglomerular Apparatus: A Renin Lineage Precursor Cell Niche for Glomerular Regeneration"
11:05 am - 11:15 am
Discussion
11:15 am - 11:40 am
Brian Belyea (University of Virginia School of Medicine, USA)
"The Origin, Fate, and Significance of Renin Progenitors During Hematopoiesis"
11:40 am - 11:50 am
Discussion
11:50 am - 11:55 am
Introduction by Discussion Leader
11:55 am - 12:10 pm
Johannes Kovarik (Signature Research Programme in Cardiovascular & Metabolic Disorders, Duke-NUS Medical School, Singapore)
"Loss of Urine Concentration and Subsequent Dehydration Characterizes Hypertension in Rats with Chronic Renal Failure"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Hannah Cooper (Lewis Katz School of Medicine, Temple University, USA)
"Mitochondrial Fission Mediates Hypertensive Vascular Remodeling"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Maria Luisa Sequeira-Lopez (University of Virginia, USA) and Rhian Touyz (University of Glasgow, United Kingdom)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cross-Talk with Angiotensin Receptors
Discussion Leaders: Akira Nishiyama (Kagawa University Medical School, Japan) and Kenneth Bernstein (Cedars-Sinai Medical Center, USA)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
Tianxin Yang (University of Utah, USA)
"The Soluble (Pro)renin Receptor: Its Generation and Function"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
Youhua Liu (University of Pittsburgh School of Medicine, USA)
"(Pro)renin and Wnt/Beta-Catenin Signaling in Chronic Kidney Disease"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:50 pm
Introduction by Discussion Leader
8:50 pm - 9:05 pm
Kirsty Pringle (University of Newcastle, Australia)
"Cleavage of the Soluble Prorenin Receptor and the Implications for Preeclamptic Pregnancies"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Sayaka Nagata (University of Miyazaki, Japan)
"Big Angiotensin-25: A Novel Component of the Renin Angiotensin System"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Novel Neural Control Mechanisms: Does the Brain Dominate the Circulation?
Discussion Leaders: Eric Lazartigues (LSU Health Sciences Center New Orleans, USA) and Barbara Alexander (University of Mississippi Medical Center, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Annette De Kloet (University of Florida, USA)
"Shedding Light on the Role of 'Angiotensin-Sensitive' Neural Circuits in the Coordination of Neuroendocrine and Autonomic Control"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
Lisete Michelini (Universidade de Sao Paulo, Brazil)
"Brain RAS, Inflammation and Blood Brain Barrier Integrity: Opposite Effects of Hypertension and Exercise Training"
10:05 am - 10:15 am
Discussion
10:15 am - 10:40 am
Coffee Break
10:40 am - 10:45 am
Introduction by Discussion Leader
10:45 am - 11:10 am
J. Thomas Cunningham (University of North Texas Health Science Center, USA)
"Role of the Brain Angiotensin System in Chronic Intermittent Hypoxia Induced Hypertension"
11:10 am - 11:20 am
Discussion
11:20 am - 11:45 am
Peng Shi (Zhejiang University, China)
"Microglial Activation Regulate Blood Pressure in Ang II Hypertension"
11:45 am - 11:55 am
Discussion
11:55 am - 12:05 pm
Sarah Sapouckey (University of Iowa, USA)
"Leptin Modulates the RAS Within the Arcuate Nucleus to Stimulate Resting Metabolic Rate"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Kento Kitada (Duke-NUS Medical School, Singapore)
"Melanocortin 3 Receptor Deletion Induces Skin-Specific Na and Water Loss that Cannot Be Compensated by Glucocorticoid-Driven Urea Osmolyte Generation and Accumulation"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Bench Comes to the Real World: MR and Its Antagonist
Discussion Leaders: Minolfa Prieto (Tulane University, USA) and Miki Nagase (Kyorin University, Japan)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
Frederic Jaisser (INSERM, France)
"Repositioning Mineralocorticoid Receptor Antagonists: Pathophysiological and Clinical Insights"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Morag Young (Hudson Institute of Medical Research, Australia)
"Putting the 'A' Back into RAAS: Mineralocorticoid Signalling in Cardiovascular Disease"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:40 pm
Introduction by Discussion Leader
8:40 pm - 8:55 pm
Nobuhiro Ayuzawa (The University of Tokyo, Japan)
"Mineralocorticoid Receptro in Renal Intercalated Cells Mediates Pendrin Regulation by Renin-Angiotensin-Aldosterone System to Maintain Fluid Homeostasis"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Claire Demiot (University of Limoges, France)
"Angiotensin II Type 2 Receptor Stimulation Decreases Sensory Neuropathy Induced by Vincristine in Mice"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Michael Boyer (Lewis Katz School of Medicine, Temple University, USA)
"Mitochondrial Fission Is Regulated by Canonical NF-kB Signaling and Is Required for Vascular Inflammation"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Gut Microbiome, Immunity, Salt-Sensitive Hypertension and the RAAS
Discussion Leaders: Steven Crowley (Duke University Medical Center, USA) and Tatsuo Shimosawa (International University of Health and Welfare, Japan)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Elaine Sumners (University of Florida, USA)
"Brain-Gut Interactions and RAS in Hypertension"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
Francine Marques (Baker Heart and Diabetes Institute, Australia)
"Hypertension and Gut Microbiota: Links and Treatment"
10:05 am - 10:15 am
Discussion
10:15 am - 10:35 am
Kenneth Bernstein (Cedars-Sinai Medical Center, USA)
"Angiotensin-Converting Enzymes Enhances the Oxidative Response and Bactericidal Activity of Neutrophils"
10:35 am - 10:40 am
Discussion
10:40 am - 11:10 am
Coffee Break
11:10 am - 11:15 am
Introduction by Discussion Leader
11:15 am - 11:40 am
Wakako Kawarazaki (Research Center for Advanced Science and Technology, The University of Tokyo, Japan)
"Vascular Rho Kinase and RAS in Ageing-Associated Salt-Sensitive Hypertension"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Jing Wu (The University of Iowa, USA)
"Smooth Muscle PPARgamma Mutation Causes Salt-Sensitive Hypertension"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Jorge Giani (Cedars-Sinai Medical Center, USA)
"The ACE N-Domain Plays an Active Role in Renal Inflammation and Sodium Retention During Diabetes Independently from Angiotensin II Generation"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Novel Approaches Open New Windows into RAS Function
Discussion Leader: Dulce Casarini (Universidade Federal de Sao Paulo, Brazil)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
Curt Sigmund (University of Iowa, USA)
"Smooth Muscle RhoBTB1 Is a Novel Regulator of Vascular Function, Arterial Stiffness and Blood Pressure"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
Catherine Llorens-Cortes (INSERM U1050, Collège de France, France)
"Central-Acting Aminopeptidase A Inhibitors for New Treatment of Hypertension and Heart Failure: From Discovery to Clinical Trial"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:50 pm
Introduction by Discussion Leader
8:50 pm - 9:05 pm
Douglas Bennion (University of Florida, USA)
"Treating Stroke via the Nose to Brain Highway: Intranasal Delivery of Angiotensin Type 2 Receptor Agonist After Ischemic Stroke Is Neuroprotective"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Ulrike Steckelings (University of Southern Denmark, Denmark)
"First-in-Man Clinical Evaluation of an Angiotensin AT2-Receptor Agonist in a Phase I, Randomised, Double-Blind Clinical Trial Revealed Safety, Tolerability and a Beneficial Effect on Lipoprotein Pattern"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Angiotensin: Possible Key for Immune Response
Discussion Leaders: Ulrich Wenzel (University Medical Center Hamburg-Eppendorf, Germany), Johannes Stegbauer (University Hospital Düsseldorf / Heinrich Heine University Düsseldorf, Germany) and Jan Danser (Erasmus MC, The Netherlands)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Philip Wenzel (University Medical Center, Johannes Gutenberg University Mainz, Germany)
"A Vascular Coagulation-Inflammatory Circuit in Arterial Hypertension"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
Giuseppe Lembo (Sapienza University of Rome / IRCCS Neuromed, Italy)
"Targeting Novel Immune Signaling in Hypertension"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 10:50 am
Introduction by Discussion Leader
10:50 am - 11:15 am
Ralf Linker (University Hospital Erlangen / Friedrich-Alexander University Erlangen-Nürnberg, Germany)
"Role of AngII in Neuroinflammation"
11:15 am - 11:25 am
Discussion
11:25 am - 11:40 am
Liang Xiao (Vanderbilt University Medical Center, USA)
"Activation of Natural Killer Cells in Recombination Activating Gene 1 Null Mice with Angiotensin II Induced Hypertension"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Jiaxi Xu (LSU Health Sciences Center New Orleans, USA)
"Role of AT1 Receptor-Mediated ADAM17 Signaling in Glutamatergic Neurons in Neurogenic Hypertension"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Mathilde Keck (INSERM U1050 / Quantum Genomics / Collège de France, France)
"NI956: A Potent Orally Active Aminopeptidase A Inhibitor with Central Antihypertensive Effects in DOCA-Salt Rats"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Maira Soto (University of Arizona, USA)
"Immunosuppression in Type 2 Diabetes Is Improved with A(1-7) Treatment in a S. aureus Infection Model"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Sex, Aging and Death in the RAAS
Discussion Leaders: Rhian Touyz (University of Glasgow, United Kingdom) and Hiroshi Akazawa (The University of Tokyo, Japan)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
Rasna Sabharwal (University of Iowa, USA)
"Sudden Death in Muscular Dystrophy: Role of the Renin-Angiotensin System"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
Jane Reckelhoff (University of Mississippi Medical Center, USA)
"Sex Differences and Aging in the RAS"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:50 pm
Introduction by Discussion Leader
8:50 pm - 9:05 pm
Mina Yakoub (University Hospital of Düsseldorf, Germany)
"Chronic Treatment of Short Chain Fatty Acids Attenuates the Development of Atherosclerosis in Angiotensin II Infused Apolipoprotein E Deficient Mice"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Bethany Dale (Vanderbilt University, USA)
"Loss of Interleukin 21 Protects Against Hypertension and Hypertension Associated Inflammation and End-Organ Damage"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure