Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Understanding Complexity to Maintain Cardiovascular Health
Discussion Leader: Ariel Gomez (University of Virginia, USA)
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:30 pm
Rhian Touyz (University of Glasgow, United Kingdom)
"Networking Through Angiotensin: From Molecules to Systems"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
Friedrich Luft (Experimental and Clinical Research Center (ECRC), Germany)
"Mechanisms that Increase Peripheral Vascular Resistance Beyond the AT1 Receptor"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
New Therapeutics Targeting the RAAS: Benefits and Risks
Discussion Leaders: Robert Carey (University of Virginia, USA) and Paul Kimmel (National Institute of Diabetes and Digestive and Kidney Diseases, NIH, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Dominik Muller (Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Germany)
"Fasting Affects Your Microbiome and Immune Cells with Long-Term Benefit for Your Blood Pressure"
9:30 am - 9:40 am
Discussion
9:40 am - 9:55 am
Qiuhong Li (University of Florida, USA)
"Oral Therapy for Diabetic Retinopathy by Genetically Engineered Probiotics Expressing Ang-(1-7)/ACE2"
9:55 am - 10:05 am
Discussion
10:05 am - 10:25 am
Gail Adler (Brigham and Women's Hospital / Harvard Medical School, USA)
"Impact of Statins on Aldosterone Biosynthesis: Potential Relevance to Cardiovascular Disease"
10:25 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:05 am
Introduction by Discussion Leader
11:05 am - 11:15 am
Rheure Lopes (University of Glasgow, United Kingdom)
"Inhibiting ACE C-Domain and Neprilysin: A Potential New Therapy in Hypertension"
11:15 am - 11:20 am
Discussion
11:20 am - 11:40 am
Ulrike Steckelings (University of Southern Denmark, Denmark)
"New Ligands and News About Old Ligands for the Angiotensin AT2-Receptor"
11:40 am - 11:50 am
Discussion
11:50 am - 12:00 pm
Donald Foster (Alnylam Pharmaceuticals, USA)
"RNAi Therapeutics Targeting Angiotensinogen"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:20 pm
Estrellita Uijl (Erasmus University Medical Center Rotterdam, The Netherlands)
"Angiotensinogen Directed siRNA: Efficacy in Hypertension and Chronic Kidney Disease"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizers: Rhian Touyz (University of Glasgow, United Kingdom) and Kathy Griendling (Emory University, USA)
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Plasticity, Repair and Rhythm in the RAAS
Discussion Leaders: Pontus Persson (Charité - Universitätsmedizin Berlin, Germany) and Christian Hugo (University Hospital Carl Gustav Carus Dresden, Germany)
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:25 pm
Paola Romagnani (Università Degli Studi di Firenze, Italy)
"Kidney Repair: Mechanisms and Trade-off"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 6:55 pm
Ming Gong (University of Kentucky, USA)
"Active Time-Restricted Feeding Potently Protects Blood Pressure Circadian Rhythm in Diabetic Mice"
6:55 pm - 7:05 pm
Discussion
7:05 pm - 7:10 pm
Introduction by Discussion Leader
7:10 pm - 7:20 pm
Omar Guessoum (University of Virginia, USA)
"Epigenetic Remodeling, Not Proliferation, Mediates Renin Cell Plasticity"
7:20 pm - 7:25 pm
Discussion
7:25 pm - 7:40 pm
Vladimir Todorov (University Hospital Dresden, TU Dresden, Germany)
"Automatic Analysis of Patterns of Differentiation of Renin-Lineage Cells During Nephrogenesis"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Mariela Gironacci (Universidad de Buenos Aires, Argentina)
"Interaction Between the Angiotensin-(1-7) Mas Receptor and the Alamandine Mas-Related G Protein-Coupled Receptor Member D Receptor"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Novel Functions of the RAAS and Its Receptors
Discussion Leaders: Kenneth Bernstein (Cedars-Sinai Medical Center, USA) and Romer Gonzalez Villalobos (Janssen Research and Development, LLC, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Jennifer Pluznick (Johns Hopkins School of Medicine, USA)
"Olfactory Receptor 78, Short Chain Fatty Acids and Blood Pressure Regulation"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Tracey Gaspari (Monash University, Australia)
"IRAP/AT4 Receptor: A New Target for the Treatment of Cardiovascular Disease"
9:55 am - 10:05 am
Discussion
10:05 am - 10:25 am
Jan Wysocki (Northwestern University, USA)
"Systemic and Kidney Effects of Novel Forms of ACE2"
10:25 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:05 am
Introduction by Discussion Leader
11:05 am - 11:25 am
Heddwen Brooks (The University of Arizona , USA)
"Sex Differences in T Cell-Dependent Ang II Hypertension"
11:25 am - 11:35 am
Discussion
11:35 am - 11:50 am
Zhenheng Guo (University of Kentucky, USA)
"Endothelial Mineralocorticoid Receptor Mediates Aldosterone and High Salt-Induced Abdominal Aortic Aneurysm in Mice"
11:50 am - 11:55 am
Discussion
11:55 am - 12:10 pm
Oleg Palygin (Medical College of Wisconsin, USA)
"Relationship Between Renin-Angiotensin-Aldosterone System and Renal Kir5.1 Channel"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Yuan Sun (Erasmus University Medical Center, The Netherlands)
"Megalin: A Novel Endocytic Receptor for Prorenin and Renin?"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
RAAS, Higher Brain and Neuroimmune Functions
Discussion Leader: Curt Sigmund (Medical College of Wisconsin, USA)
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:25 pm
Paul Marvar (George Washington University, USA)
"Angiotensin II and Fear Memory: Implications for Post-Traumatic Stress Disorder (PTSD) and Co-Morbid Cardiovascular Disease"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 6:55 pm
Ihab Hajjar (Emory University, USA)
"Role of RAAS Modulation in Neurocognitive Therapeutics"
6:55 pm - 7:05 pm
Discussion
7:05 pm - 7:25 pm
Daniela Carnevale (Sapienza University of Rome / IRCCS Neuromed, Italy)
"New Molecular Mechanisms of Neural Regulation of Immunity in Hypertension"
7:25 pm - 7:35 pm
Discussion
7:35 pm - 7:50 pm
Christopher Wilcox (Georgetown University, USA)
"Resilience of Cerebral Arterioles to Vasoconstriction Protects the Brain from Vascular Dementia and Stroke"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Single Cells, Epigenetics and Genome Engineering
Discussion Leaders: Johannes Stegbauer (University Hospital Düsseldorf / Heinrich Heine University Düsseldorf, Germany) and Silvia Medrano (University of Virginia, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Kathleen Rodgers (University of Arizona, USA)
"The Therapeutic Potential of Mas Activation"
9:25 am - 9:35 am
Discussion
9:35 am - 9:45 am
Kenneth Bernstein (Cedars-Sinai Medical Center, USA)
"ACE and Mitochondrial Function"
9:45 am - 9:50 am
Discussion
9:50 am - 10:00 am
Allen Cowley (Medical College of Wisconsin, USA)
"Angiotensin II Induced Renal Injury"
10:00 am - 10:05 am
Discussion
10:05 am - 10:20 am
M. Carolina Florian (Center of Regenerative Medicine in Barcelona (CMRB), Spain)
"Aging Alters the Epigenetic Asymmetry of Stem Cell Division"
10:20 am - 10:25 am
Discussion
10:25 am - 10:50 am
Coffee Break
10:50 am - 10:55 am
Introduction by Discussion Leader
10:55 am - 11:15 am
Carlos Bernal-Mizrachi (Washington University in St. Louis, USA)
"Hypertension and Inflammation: Unexpected Communication Between Innate Immunity and Juxtaglomerular Cells"
11:15 am - 11:25 am
Discussion
11:25 am - 11:45 am
Mazhar Adli (Northwestern University, USA)
"Genome Engineering and High Throughput Screening Combinatorial Drug Targets"
11:45 am - 11:55 am
Discussion
11:55 am - 12:05 pm
Alexandre Martini (University of Virginia, USA)
"Fate of Renin Cell Progenitors in the Developing Kidney Vasculature"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Francine Marques (Monash University, Australia)
"Global Deletion of MicroRNA-181a Results in Elevated Blood Pressure and Salt Sensitivity in Mice via Up-Regulation of Renin"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Advances in Imaging
Discussion Leaders: Charlotte Buckley (University of Strathclyde, United Kingdom) and Armin Kurtz (University of Regensburg, Germany)
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:25 pm
Sebastian Temme (Heinrich Heine University Düsseldorf, Germany)
"Imaging of Vascular Inflammation During the Formation of Abdominal Aortic Aneurysms by Noninvasive 1H/19F Magnetic Resonance Imaging"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 6:55 pm
John Mullins (University of Edinburgh, United Kingdom)
"The Application of Biophotonics in the Zebrafish to Explore the Biology of Renin Cells"
6:55 pm - 7:05 pm
Discussion
7:05 pm - 7:10 pm
Introduction by Discussion Leader
7:10 pm - 7:25 pm
Janos Peti-Peterdi (University of Southern California, USA)
"Intravital Imaging of Macula Densa-Mediated Renal Vascular and Glomerular Remodeling"
7:25 pm - 7:35 pm
Discussion
7:35 pm - 7:50 pm
Mariela Mendez (Henry Ford Hospital, USA)
"Advancements in Imaging Renin Release and Cell Biology in Juxtaglomerular Cells"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Precision Medicine, Big Data and the RAAS
Discussion Leaders: Allen Cowley (Medical College of Wisconsin, USA), Marko Poglitsch (Attoquant Diagnostics, Austria) and Tatsuo Shimosawa (International University of Health and Welfare, Japan)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Maria-Christina Zennaro (Inserm, France)
"Applying Omics-Based Approaches for the Diagnosis of Endocrine Hypertension"
9:25 am - 9:35 am
Discussion
9:35 am - 9:50 am
Augusto Montezano (Institute of Cardiovascular and Medical Sciences, University of Glasgow, United Kingdom)
"Enhancing Interactions Between MasR and ETBR as a New Vasoprotective Strategy"
9:50 am - 9:55 am
Discussion
9:55 am - 10:05 am
Masudur Rahman (University Hospital of Düsseldorf, Germany)
"Role of Human T Cells in Resistant Hypertension"
10:05 am - 10:10 am
Discussion
10:10 am - 10:20 am
Jing Wu (Medical College of Wisconsin, USA)
"Endothelial Cullin3 Mutation Causes Vascular Dysfunction, Arterial Stiffening and Hypertension"
10:20 am - 10:25 am
Discussion
10:25 am - 10:50 am
Coffee Break
10:50 am - 10:55 am
Introduction by Discussion Leader
10:55 am - 11:15 am
Jose Krieger (Heart Institute (InCor), University of Sao Paulo Medical School, Brazil)
"An Integrated Forward Genetic Screen to Identify Genes Influencing Blood Pressure and Hypertension"
11:15 am - 11:25 am
Discussion
11:25 am - 11:45 am
Yuichiro Yano (Duke University, USA)
"Blood Pressure Management in Young Adults"
11:45 am - 11:55 am
Discussion
11:55 am - 12:00 pm
Introduction by Discussion Leader
12:00 pm - 12:10 pm
Solène Boitard-Joanne (Collège de France / Quantum Genomics, France)
"Brain Renin-Angiotensin System Blockade with Firibastat, an Orally Active, Central Acting Aminopeptidase A Inhibitor Prodrug Prevents Cardiac Dysfunction After Myocardial Infarction in Mice"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Danielle Coutinho (Federal University of Minas Gerais, Brazil)
"Cardioprotective Effect of Diminazene Aceturate in Ischemic Reperfusion-Induced Cardiac Injury"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Keynote Session: From Molecular Mechanisms to Public Health Impact
Discussion Leader: Ulrike Steckelings (University of Southern Denmark, Denmark)
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:45 pm
Kathy Griendling (Emory University, USA)
"Angiotensin II and Reactive Oxygen Species: A Complex Journey to Endothelial Permeability"
6:45 pm - 6:55 pm
Discussion
6:55 pm - 7:35 pm
Gary Gibbons (National Heart, Lung, and Blood Institute, NIH, USA)
"Translating Discovery Science into Cardiovascular Health"
7:35 pm - 7:45 pm
Discussion
7:45 pm - 8:00 pm
Closing Remarks
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure