Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Understanding Complexity to Maintain Cardiovascular Health
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:30 pm
"Networking Through Angiotensin: From Molecules to Systems"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
"Mechanisms that Increase Peripheral Vascular Resistance Beyond the AT1 Receptor"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
New Therapeutics Targeting the RAAS: Benefits and Risks
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Fasting Affects Your Microbiome and Immune Cells with Long-Term Benefit for Your Blood Pressure"
9:30 am - 9:40 am
Discussion
9:40 am - 9:55 am
"Oral Therapy for Diabetic Retinopathy by Genetically Engineered Probiotics Expressing Ang-(1-7)/ACE2"
9:55 am - 10:05 am
Discussion
10:05 am - 10:25 am
"Impact of Statins on Aldosterone Biosynthesis: Potential Relevance to Cardiovascular Disease"
10:25 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:05 am
Introduction by Discussion Leader
11:05 am - 11:15 am
"Inhibiting ACE C-Domain and Neprilysin: A Potential New Therapy in Hypertension"
11:15 am - 11:20 am
Discussion
11:20 am - 11:40 am
"New Ligands and News About Old Ligands for the Angiotensin AT2-Receptor"
11:40 am - 11:50 am
Discussion
11:50 am - 12:00 pm
"RNAi Therapeutics Targeting Angiotensinogen"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:20 pm
"Angiotensinogen Directed siRNA: Efficacy in Hypertension and Chronic Kidney Disease"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Plasticity, Repair and Rhythm in the RAAS
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:25 pm
"Kidney Repair: Mechanisms and Trade-off"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 6:55 pm
"Active Time-Restricted Feeding Potently Protects Blood Pressure Circadian Rhythm in Diabetic Mice"
6:55 pm - 7:05 pm
Discussion
7:05 pm - 7:10 pm
Introduction by Discussion Leader
7:10 pm - 7:20 pm
"Epigenetic Remodeling, Not Proliferation, Mediates Renin Cell Plasticity"
7:20 pm - 7:25 pm
Discussion
7:25 pm - 7:40 pm
"Automatic Analysis of Patterns of Differentiation of Renin-Lineage Cells During Nephrogenesis"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Interaction Between the Angiotensin-(1-7) Mas Receptor and the Alamandine Mas-Related G Protein-Coupled Receptor Member D Receptor"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Novel Functions of the RAAS and Its Receptors
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Olfactory Receptor 78, Short Chain Fatty Acids and Blood Pressure Regulation"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"IRAP/AT4 Receptor: A New Target for the Treatment of Cardiovascular Disease"
9:55 am - 10:05 am
Discussion
10:05 am - 10:25 am
"Systemic and Kidney Effects of Novel Forms of ACE2"
10:25 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:05 am
Introduction by Discussion Leader
11:05 am - 11:25 am
"Sex Differences in T Cell-Dependent Ang II Hypertension"
11:25 am - 11:35 am
Discussion
11:35 am - 11:50 am
"Endothelial Mineralocorticoid Receptor Mediates Aldosterone and High Salt-Induced Abdominal Aortic Aneurysm in Mice"
11:50 am - 11:55 am
Discussion
11:55 am - 12:10 pm
"Relationship Between Renin-Angiotensin-Aldosterone System and Renal Kir5.1 Channel"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Megalin: A Novel Endocytic Receptor for Prorenin and Renin?"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
RAAS, Higher Brain and Neuroimmune Functions
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:25 pm
"Angiotensin II and Fear Memory: Implications for Post-Traumatic Stress Disorder (PTSD) and Co-Morbid Cardiovascular Disease"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 6:55 pm
"Role of RAAS Modulation in Neurocognitive Therapeutics"
6:55 pm - 7:05 pm
Discussion
7:05 pm - 7:25 pm
"New Molecular Mechanisms of Neural Regulation of Immunity in Hypertension"
7:25 pm - 7:35 pm
Discussion
7:35 pm - 7:50 pm
"Resilience of Cerebral Arterioles to Vasoconstriction Protects the Brain from Vascular Dementia and Stroke"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Single Cells, Epigenetics and Genome Engineering
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"The Therapeutic Potential of Mas Activation"
9:25 am - 9:35 am
Discussion
9:35 am - 9:45 am
"ACE and Mitochondrial Function"
9:45 am - 9:50 am
Discussion
9:50 am - 10:00 am
"Angiotensin II Induced Renal Injury"
10:00 am - 10:05 am
Discussion
10:05 am - 10:20 am
"Aging Alters the Epigenetic Asymmetry of Stem Cell Division"
10:20 am - 10:25 am
Discussion
10:25 am - 10:50 am
Coffee Break
10:50 am - 10:55 am
Introduction by Discussion Leader
10:55 am - 11:15 am
"Hypertension and Inflammation: Unexpected Communication Between Innate Immunity and Juxtaglomerular Cells"
11:15 am - 11:25 am
Discussion
11:25 am - 11:45 am
"Genome Engineering and High Throughput Screening Combinatorial Drug Targets"
11:45 am - 11:55 am
Discussion
11:55 am - 12:05 pm
"Fate of Renin Cell Progenitors in the Developing Kidney Vasculature"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Global Deletion of MicroRNA-181a Results in Elevated Blood Pressure and Salt Sensitivity in Mice via Up-Regulation of Renin"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:25 pm
"Imaging of Vascular Inflammation During the Formation of Abdominal Aortic Aneurysms by Noninvasive 1H/19F Magnetic Resonance Imaging"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 6:55 pm
"The Application of Biophotonics in the Zebrafish to Explore the Biology of Renin Cells"
6:55 pm - 7:05 pm
Discussion
7:05 pm - 7:10 pm
Introduction by Discussion Leader
7:10 pm - 7:25 pm
"Intravital Imaging of Macula Densa-Mediated Renal Vascular and Glomerular Remodeling"
7:25 pm - 7:35 pm
Discussion
7:35 pm - 7:50 pm
"Advancements in Imaging Renin Release and Cell Biology in Juxtaglomerular Cells"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Precision Medicine, Big Data and the RAAS
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Applying Omics-Based Approaches for the Diagnosis of Endocrine Hypertension"
9:25 am - 9:35 am
Discussion
9:35 am - 9:50 am
"Enhancing Interactions Between MasR and ETBR as a New Vasoprotective Strategy"
9:50 am - 9:55 am
Discussion
9:55 am - 10:05 am
"Role of Human T Cells in Resistant Hypertension"
10:05 am - 10:10 am
Discussion
10:10 am - 10:20 am
"Endothelial Cullin3 Mutation Causes Vascular Dysfunction, Arterial Stiffening and Hypertension"
10:20 am - 10:25 am
Discussion
10:25 am - 10:50 am
Coffee Break
10:50 am - 10:55 am
Introduction by Discussion Leader
10:55 am - 11:15 am
"An Integrated Forward Genetic Screen to Identify Genes Influencing Blood Pressure and Hypertension"
11:15 am - 11:25 am
Discussion
11:25 am - 11:45 am
"Blood Pressure Management in Young Adults"
11:45 am - 11:55 am
Discussion
11:55 am - 12:00 pm
Introduction by Discussion Leader
12:00 pm - 12:10 pm
"Brain Renin-Angiotensin System Blockade with Firibastat, an Orally Active, Central Acting Aminopeptidase A Inhibitor Prodrug Prevents Cardiac Dysfunction After Myocardial Infarction in Mice"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Cardioprotective Effect of Diminazene Aceturate in Ischemic Reperfusion-Induced Cardiac Injury"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Keynote Session: From Molecular Mechanisms to Public Health Impact
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:45 pm
"Angiotensin II and Reactive Oxygen Species: A Complex Journey to Endothelial Permeability"
6:45 pm - 6:55 pm
Discussion
6:55 pm - 7:35 pm
"Translating Discovery Science into Cardiovascular Health"
7:35 pm - 7:45 pm
Discussion
7:45 pm - 8:00 pm
Closing Remarks
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure