The RAAS: Molecular Networking to Multi-System Pathophysiology

The 2022 Angiotensin GRC will focus on “The RAAS: Molecular Networking to Multi-System Pathophysiology.”

Significant advances in the RAAS field from discovery science to clinical impact will be discussed. Our conference will celebrate the 42^nd anniversary of the Angiotensin GRC and 22 years of the discovery of ACE2. Experts in the field will highlight new advances in the RAAS and will discuss the enigmas of ACE2 as a key enzyme in the protective arm of the RAAS and as the receptor for SARS-CoV-2, which causes COVID-19. This conference will feature novel topics including the role of the RAAS in non-cardiovascular systems, such as adipose tissue, bone marrow, liver, and immune cells and associated molecular mechanisms underpinning effects of Ang II and its peptides in these systems. Controversies on the role of the RAAS in COVID-19 infection will also be addressed. The meeting will further comprise emerging topics including sex-differences in the regulation of the RAAS during the life course. In line with precision medicine being the next frontier in clinical medicine, the meeting will highlight new advances in the pharmacogenomics, proteomics, and metabolomics of the RAAS in human disease and the impact on drug discovery.

During the 2022 Angiotensin GRC, discussions will be based on preliminary unpublished results from Basic Research, Clinical Studies and Clinical Trials, presented by diverse groups of internationally and nationally recognized basic, clinical, and translational investigators from all career stages. To enhance the opportunities for networking among junior investigators, trainees, and global leaders in the field, the conference will include: 1) Four poster sessions, 2) The Power Hour™, an open forum to address diversity and inclusion in the scientific workplace and support professional growth of all members of our community, 3) Several speaker slots that have been purposely left available for short-oral presentations selected from abstracts of late-breaking advances and trainees, and 4) Many opportunities to interact during lunch and dinners pre-arranged inside the conference venue. The conference will be preceded by a two-days Gordon Research Seminar (GRS) designed for and to scientists in training. Those interested in attending both meetings must apply for the GRS in addition to apply for the GRC. Refer to the associated GRS program page for more information.

The main goals of the GRC are to provide an ideal environment to advance the scientific career of early-stage investigators, establish new cross-disciplinary national and international collaborations, and nurture the interactions between trainees and established investigators through formal presentations and informal daily communications during and after the conference. This is the venue to make new friends and to establish new and long-lasting collaborations.