Saturday
1:30 pm - 4:30 pm
Arrival and Check-in
3:00 pm - 3:15 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:15 pm - 4:00 pm
Keynote Session: Exploring the Therapeutic Arm of Renin Angiotensin Aldosterone System
This session will focus on the therapeutic potential of the non-classical arm of RAAS. Attendees will learn about the best strategies for the development of novel therapeutics while in an academic environment and the possibilities for RAAS-research in diseases beyond hypertension.
Discussion Leader: Eve Kelland (University of Southern California, USA)
3:15 pm - 3:50 pm
Augusto Montezano (Institute of Cardiovascular and Medical Sciences, University of Glasgow, United Kingdom)
"Enhancing Interactions Between Mas and ETBR as a New Vasoprotective Strategy"
3:50 pm - 4:00 pm
Discussion
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
The Role of RAAS in Diseases Beyond Hypertension
For the last 40+ years, the RAAS field has focused on hypertension. Only recently has there been work done on the impact of RAAS on other diseases such as dementia, lupus and muscular dystrophy.
Discussion Leaders: Ariel Gomez (University of Virginia, USA) and Catherine Llorens-Cortes (INSERM U1050, France)
5:30 pm - 5:45 pm
Shalinee Jha (Graz University of Technology, Austria)
"Dipeptidyl Peptidase 3 Modulates the Renin-Angiotensin-Aldosterone System"
5:45 pm - 5:50 pm
Discussion
5:50 pm - 6:05 pm
Yan Wang (Monash University, Australia)
"Novel Angiotensin Type 2 Receptor Agonist Is Anti-Fibrotic in Heart and Kidney"
6:05 pm - 6:10 pm
Discussion
6:10 pm - 6:25 pm
Benedikt Marahrens (Northwestern University, USA / Charité - Universitätsmedizin Berlin, Germany)
"Functional Intrarenal Alterations and Morphological Glomerular Basement Changes in Mice Deficient of the Angiotensinase Aminopeptidase A"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:45 pm
Danielle Coutinho (Federal University of Minas Gerais, Brazil)
"Cardioprotective Effect of Diminazene Aceturate in Ischemic Reperfusion-Induced Cardiac Injury"
6:45 pm - 6:50 pm
Discussion
6:50 pm - 7:05 pm
Mina Shirazi (Northwestern University, USA / Charité - Universitätsmedizin Berlin, Germany)
"A Novel Angiotensin-Converting Enzyme 2 Truncate Markedly Improves Ischemic Acute Kidney Injury"
7:05 pm - 7:10 pm
Discussion
7:10 pm - 7:30 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
The RAAS in the Bioinformatics Age and Understanding Receptors and Signaling in the Classical and Non-Classical RAAS
Current research relies heavily on techniques that generate large amounts of data. New strategies are being developed in order to be able to accurately analyze this data. Top scored abstracts about how the bioinformatics age impacts research within the RAAS will be invited to present their most recent and unpublished research. Defining a single RAAS pathway has not been possible since the signaling depends on the tissue and the disease state.
Discussion Leader: Maria Luisa Sequeira-Lopez (University of Virginia, USA)
9:00 am - 9:15 am
Omar Guessoum (University of Virginia, USA)
"Epigenetic Remodeling, Not Proliferation, Mediates Renin Cell Plasticity"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Rheure Lopes (University of Glasgow, United Kingdom)
"Combination of Selective Inhibition of Angiotensin-Converting Enzyme C-Domain with Sacubitril Prevents Hypertension-Associated Vascular Damage and Reduces Systolic Blood Pressure"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Robert Paxton (Child Health Research Center, University of Virginia School of Medicine, USA)
"Role of Aldo-Keto Reductases 1B in Renin Cells"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Jing Wu (Medical College of Wisconsin, USA)
"Endothelial Cullin3 Mutation Causes Vascular Dysfunction, Arterial Stiffening and Hypertension"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Solène Boitard-Joanne (Collège de France / Quantum Genomics, France)
"Brain Renin-Angiotensin System Blockade with Firibastat, an Orally Active, Central Acting Aminopeptidase A Inhibitor Prodrug Prevents Cardiac Dysfunction After Myocardial Infarction in Mice"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
Alexandre Martini (University of Virginia, USA)
"Fate of Renin Cell Progenitors in the Developing Kidney Vasculature"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Young Investigator Careers: Moving on to the Next Step
Mentorship is an important part of any scientific career, here the goal is to discuss how to find and maintain a good relationship with a mentor early on. Translational science has become a mainstay in research both in academia and industry. The main goal is how to identify a potentially innovative idea for the successful association between academia and industry.
Discussion Leader: Augusto Montezano (Institute of Cardiovascular and Medical Sciences, University of Glasgow, United Kingdom)
1:30 pm - 1:55 pm
Kathy Griendling (Emory University, USA)
"Moving on to the Next Step: The Importance of Mentoring"
1:55 pm - 2:00 pm
Discussion
2:00 pm - 2:25 pm
Rodrigo Fraga-Silva (Ecole Polytechnique Federale de Lausanne, Switzerland)
"Startup Environment: Opportunities for Scientists Outside the Academia"
2:25 pm - 2:30 pm
Discussion
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes
