Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Keynote Session: RAAS Beyond Blood Pressure Regulation
Novel Phenomena in RAAS Control: This session will focus on rapid and recent advances in RAAS studies beyond the classical paradigm. With the advent of next-generation sequencing and emerging technologies, mentees will gain new insights into RAAS function and an enhanced understanding of current tools to aid their research.
3:45 pm - 4:20 pm
"Novel Phenomena in RAAS Control"
4:20 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Novel Functions of Receptors from RAAS
In this session, RAAS receptors will be highlight in terms of their novel interactions ranging from co-opting by viruses to regulation of immune and neurological functions. Trainees will gain an enhanced understanding of the diversity of roles played by receptors involved in the RAAS beyond traditional models.
7:30 pm - 7:45 pm
"Proof of Biological Activity and Exploration of Early Signaling Events of Angiotensin"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
"Vascular Changes and Circulatory Stress in Fetuses Born from COVID-19 Pregnancies"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
"Chronic High Salt Diets Contribute to Neurogenic Hypertension by Increasing B1R Expression and B1R-Mediated ACE2 Internalization and Degradation"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"Dysregulation of ACE2 and Renin-angiotensin Peptides in SARS-CoV-2 Mediated Pathophysiology"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"Blood Pressure-Independent Renoprotection In Diabetic Rats Treated with Small Interfering RNA Targeting Liver Angiotensinogen"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"The Metabolically Stable Apelin-17 Analog LIT01 -196 Improves Cardiac Function and Reduces Cardiac Remodeling in Heart Failure after Myocardial Infarction"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
RAAS in the Immune System and Beyond Classical Signaling
A link between inflammatory cells and cardiovascular disease has long been recognized. In this session, the audience will be exposed to and appreciate the latest research on modulation of RAAS system by the innate and adaptive immune system. The second half of this session will focus on sex differences and aging in the modulation of the RAAS. The audience will improve their understanding on sex differences in the RAAS and recognize the importance of aging in the activation of this system.
9:00 am - 9:15 am
"Modulation of the Renin-angiotensin System to Reduce Immunopathology in SARS-CoV-2 and Influenza A Infection"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
"Endothelial Cell Immunoproteasome Expression Contributes to Neo-antigen Presentation and Immune Activation in Hypertension"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
"Conditional Over-expression of Heme-oxygenase 1 in Myelomonocytic Cells Reduces Hypertension and Vascular Inflammation"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
"Differences and Similarities Between Cardiovascular Responses to Val5 and Ile5 Angiotensin II Preparations – Refining of a Well-known Mouse Model of Hypertension"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
"Macrophage Angiotensin-Converting Enzyme Attenuates Atherosclerosis by Increasing ß-oxidation and PPARa Activation"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
"Important Roles of Sirt3 on Kidney Functions of Wildtype and Sirt3 Knockout Mice During Angiotensin II-Induced Hypertension"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Young Investigator Careers: The Interplay Between Industry, Academia and the Clinic
This session invites researchers to share and discuss key initial career advice from three perspectives: academic, industrial and clinical. In addition to highlighting cooperation between universities and industry, this session will also provide insights into potential career paths as clinician-scientists.
1:30 pm - 1:50 pm
"Aminopeptidase A Inhibitors: From the Bench to the Pharmaceuticals Industry"
1:50 pm - 2:00 pm
Discussion
2:00 pm - 2:20 pm
"Translational Research for Impact on Health"
2:20 pm - 2:30 pm
Discussion
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes
