SUNDAY |
4:00 pm - 8:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:45 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | FROM B CELLS TO THERAPEUTIC ANTIBODIES |
| Discussion Leader: J. Donald Capra (Oklahoma Medical Research Foundation) |
7:40 pm - 7:50 pm | Don Capra (Oklahoma Medical Research Foundation)
"Opening remarks" |
7:50 pm - 8:30 pm | Gregory Winter (Medical Research Council)
"From Antibodies to Bicycles" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:20 pm | Gary Nabel (NIAID, NIH)
"Rational design and delivery of optimized broadly neutralizing Abs to HIV" |
9:20 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | NATURAL AND SYNTHETIC EVOLUTION OF THE ANTIBODY RESPONSE |
| Discussion Leader: Max Cooper (Emory University) |
9:00 am - 9:10 am | Max Cooper (Emory University)
"Opening remarks" |
9:10 am - 9:35 am | Andreas Plückthun (University of Zurich)
"DARPins in tumor targeting" |
9:35 am - 9:45 am | Discussion |
9:45 am - 10:10 am | Michael Feldhaus (Adimab)
"Cell based selections using a yeast based antibody discovery platform" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Coffee Break |
10:50 am - 11:15 am | Brantley Herrin (Emory University)
"Naturally occurring Leucine-rich repeat-based antibodies in lampreys" |
11:15 am - 11:25 am | Discussion |
11:25 am - 11:35 am | Laird Bloom (Pfizer)
"Fundamental characteristics of the immunoglobulin Vh repertoire of chickens in comparison to those of humans, mice and camelids" |
11:35 am - 11:40 am | Discussion |
11:40 am - 11:50 am | John Lofblom (Royal Institute of Technology - KTH)
"Generation and in vitro characterization of HER3-specific Affibody molecules" |
11:50 am - 11:55 am | Discussion |
11:55 am - 12:05 pm | David King (AnaptysBio)
"Reproducing somatic hypermutation in vitro enables isolation and maturation of antibodies for therapy" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:20 pm | Gabriel Cheung (Cell Signaling Technology)
"A proteomics approach for the identification and cloning of monoclonal antibodies from serum" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | THE ANTIBODY REPERTOIRE - DEVELOPMENT AND CHARACTERIZATION |
| Discussion Leader: Herbert Morse III (NIAID) |
7:30 pm - 7:40 pm | Herbert Morse III (NIAID)
"Opening remarks" |
7:40 pm - 8:05 pm | Ann Feeney (Scripps)
"Epigenetic and 3-dimensional regulation of antibody repertoire formation" |
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:40 pm | Rafael Casellas (NIAMS)
"Genomic targets of AID and RPA in B lymphocytes" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | George Georgiou (University of Texas Austin)
"High throughput sequencing of B cell repertoires in normal and diseased individuals" |
9:15 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | B CELL RESPONSE - DRIVERS AND CONTROLLERS |
| Discussion Leader: Hideki Ueno (Baylor Institute for Immunology Research) |
9:00 am - 9:10 am | Hideki Ueno (Baylor Institute for Immunology Research)
"Opening remarks" |
9:10 am - 9:35 am | Carola Vinuesa (John Curtin School of Medical Research)
"Follicular helper, follicular regulatory and follicular NK T cells" |
9:35 am - 9:45 am | Discussion |
9:45 am - 10:10 am | Andrea Cerutti (Mount Sinai School of Medicine)
"Regulation of B cell differentiation and antibody production" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Coffee Break |
10:50 am - 11:15 am | Stuart Tangye (Garvan Institute)
"Human B cell drivers" |
11:15 am - 11:25 am | Discussion |
11:25 am - 11:50 am | Harvey Cantor (Harvard Medical School)
"Control of germinal center responses by CD8+ regulatory T cells" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Alejo Chorny (Mount Sinai School of Medicine)
"The soluble pattern recognition receptor PTX3 delivers B cell stimulating signals" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | John Schrader (The Biomedical Research Centre, UBC)
"Genetic and functional analysis of pathogenic human monoclonal auto-antibodies" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | THE ANTIBODY RESPONSE IN INFECTIOUS DISEASES |
| Discussion Leader: John Schrader (The Biomedical Research Centre, UBC) |
7:30 pm - 7:55 pm | Wayne Marasco (Dana Farber Cancer Institute)
"Challenges to a universal Influenza vaccine" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Patrick Wilson (University of Chicago)
"Antibody response to influenza" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 8:50 pm | Xiaoti Guo (NIAID, NIH)
"Triggering a CD4-binding site antibody, VRC01, and its germline precursor on B cells" |
8:50 pm - 8:55 pm | Discussion |
8:55 pm - 9:10 pm | Jonathan Lai (Albert Einstein College of Medicine)
"Intermediates in the Ebola virus membrane fusion pathway targeted synthetic antibodies" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Hwan Keun Kim (University of Chicago)
"Monoclonal antibodies against nontoxigenic protein A prevent S. aureus abscess formation in mice" |
9:25 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | BIOLOGY AND EXPLOITATION OF FC RECEPTORS |
| Discussion Leader: Richard Blumberg (Harvard Medical School) |
9:00 am - 9:10 am | Richard Blumberg (Harvard Medical School)
"Opening remarks" |
9:10 am - 9:35 am | Sally Ward (UTSW)
"Targeting FcRn for therapy" |
9:35 am - 9:45 am | Discussion |
9:45 am - 10:10 am | John Desjarlais (Xencor)
"Creation of novel antibody properties and activities with Fc engineering" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Coffee Break |
10:50 am - 11:15 am | Leo James (MRC)
"TRIM21 mediated intracellular antibody neutralization" |
11:15 am - 11:25 am | Discussion |
11:25 am - 11:35 am | Kristi Baker (Brigham & Woman's/Harvard)
"The neonatal Fc receptor for IgG, FcRn, regulates homeostatic CD8+ T cell activation in non-inflamed mucosal sites" |
11:35 am - 11:40 am | Discussion |
11:40 am - 11:50 am | Jan Terje Andersen (Oslo University Hospital/University)
"Extending the half-life of scFv-fragments using super albumin variants" |
11:50 am - 11:55 am | Discussion |
11:55 am - 12:05 pm | Omid Vafa (Janssen Research and Development)
"Anti-CD20 Ig2sigma demonstrates in vivo B-cell depletion independent of immune effector functions" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:20 pm | Thomas Spreter Von Kreudenstein (Zymeworks, Inc.)
"Optimized Fc heterodimers for improved purity and stability in the development of bispecific antibodies" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | TARGETED DELIVERY OF ANTIBODIES et al |
| Discussion Leader: Davinder Gill (Hilleman Laboratories) |
7:30 pm - 7:40 pm | Davinder Gill (Hilleman Laboratories)
"Opening remarks" |
7:40 pm - 8:05 pm | Mark Dennis (Genentech)
"Transfer'rin antibodies into the brain" |
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:40 pm | Jan Schnitzer (Proteogenomics Research Institute for Systems Medicine)
"Overcoming the endothelial cell barrier to penetrate solid tumors"
|
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | Carlos Barbas (Scripps)
"From bi to pentaspecific antibodies: Zybodies as a practical approach to multispecificity and exceptional therapeutics" |
9:15 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am - 9:00 am | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
9:00 am - 12:30 pm | NEXT GEN ANTIBODY-BASED THERAPEUTICS - DESIGN TO APPLICATION |
| Discussion Leader: Paul Carter (Genentech) |
9:00 am - 9:10 am | Paul Carter (Genentech)
"Opening remarks" |
9:10 am - 9:35 am | Jonathan Drachman (Seattle Genetics)
"SGN-35 and other auristatin-based antibody-drug conjugates" |
9:35 am - 9:45 am | Discussion |
9:45 am - 10:10 am | Ellen Filvaroff (Genentech)
"Development and activity of MetMAb" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Coffee Break |
10:50 am - 11:15 am | Janine Schuurman (GenMab)
"Efficient post-production generation of bispecific IgG1 via controlled Fab-arm exchange" |
11:15 am - 11:25 am | Discussion |
11:25 am - 11:35 am | Ykelien Boersma (CSIRO)
"EGFR-specific DARPins as potential cancer therapeutics" |
11:35 am - 11:40 am | Discussion |
11:40 am - 11:50 am | Jijie Gu (Abbott Bioresearch Center)
"DVD - Ig molecules reveal novel receptor biology and potentially novel therapeutic modality" |
11:50 am - 11:55 am | Discussion |
11:55 am - 12:05 pm | Phillip Bardwell (Abbott)
"A Novel Monovalent Format to Target T Cells to Tumor Cells using Dual Variable Domain-Immunoglobulins (DVD-IgTM)" |
12:05 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II |
6:00 pm | Dinner |
7:30 pm - 8:30 pm | MICE and COMPUTERS FOR MAKING THERAPEUTIC ANTIBODIES |
| Discussion Leaders: Derry Roopenian (The Jackson Laboratory) and Davinder Gill (Hilleman Laboratories) |
7:30 pm - 7:40 pm | Glenn Friedrich (Kymab)
"Robust mouse ES technology used to generate megabase human immunoglobin transgenics" |
7:40 pm - 7:50 pm | Discussion |
7:50 pm - 8:00 pm | Andrew Murphy (Regeneron Pharmaceuticals)
"Engineering mouse antigen receptor genes at the megabase scale" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:20 pm | Sandeep Kumar (Pfizer)
"Understanding aggregation and immunogenicity in therapeutic mAbs via biopharmaceutical informatics" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 9:30 pm | AD HOC PANEL: LESSONS, CHALLENGES and OPPORTUNITIES |
| (Moderator and Discussants to be selected at the meeting) |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |