Sunday |
4:00 pm - 8:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Keynote Session: Perspectives on Antibody Biology and Engineering |
| Discussion Leaders: Omid Vafa (TENEObio, Inc., USA) and Derry Roopenian (The Jackson Laboratory, USA) |
7:40 pm - 7:50 pm | Opening Remarks |
7:50 pm - 8:30 pm | Sally Ward (Texas A&M University, USA) "Targeting FcRn for Diagnosis and Therapy" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:20 pm | Paul Carter (Genentech, Inc., USA) "The Rise of Bispecific Antibodies as Therapeutics" |
9:20 pm - 9:30 pm | Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Antibody Structure and Dynamics in Relation to Function |
| This session focuses on new insights into how antibody structure influences its function and considers issues of evolutionary strategies, structural basis for antibody functions and how they can be manipulated. |
| Discussion Leaders: Brian Sutton (King's College London, United Kingdom) and John Desjarlais (Xencor, USA) |
9:00 am - 9:25 am | Sarel Fleishman (Weizmann Institute of Science, Israel) "Computational Design of Function, Stability and Conformational Change in Antibodies" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Gary Gilliland (Janssen, USA) "Structural Diversity in a Human Antibody
Germline Library" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:40 am | Coffee Break |
10:40 am - 11:05 am | Floyd Romesberg (The Scripps Research Institute, USA) "Evolution of Immunological Molecular Recognition" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:40 am | Clarissa Jakob (AbbVie, USA) "The Dynamic DVD-IgTM: Molecules in Motion at Atomic Resolution" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:00 pm | Tein Foong Leong (University of Dundee, United Kingdom) "Engineering Novel IgG Antibodies to Probe Immunoglobulin Function and Develop Cancer Vaccines" |
12:00 pm - 12:05 pm | Discussion |
12:05 pm - 12:15 pm | John Karanicolas (University of Kansas, USA) "Modulating Antibody Activity Using Chemical Biology" |
12:15 pm - 12:20 pm | Discussion |
12:20 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Modeling Antibody Diversity – Its Generation and Uses |
| This session focuses on understanding how diversity develops during an immune response and how this can be used for therapeutic approaches including novel mimetics, which target the antigen-antibody binding site. |
| Discussion Leader: George Georgiou (The University of Texas at Austin, USA) |
7:30 pm - 7:55 pm | Jamie Scott (Simon Fraser University, Canada) "Evolution of the Antibody Response During Hyper-Immunization with a Nanoparticle Vaccine Carrier" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Jarrett Adams (University of Toronto, Canada) "Synthetic
Repertoires" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:05 pm | DeKuan Chang (AbVitro Inc, USA) "AbPair: High Throughput Single Cell Sequencing of Tumor-Infiltrating Paired Immune Repertoires" |
9:05 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Jeffrey Gildersleeve (National Cancer Institute, NIH, USA) "Immunological Evolution of Antibodies in the Ganglioside GD2" |
9:25 pm - 9:30 pm | Discussion |
Tuesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | The Functionality of Antibodies and the Receptors Through Which They Operate: Functional Consequences |
| This session aims not to solely focus on Fc-gamma receptors/FcRn and IgG, but also on what other isotypes and recently identified receptors (e.g. TRIM21, FcRL) teach to explore new avenues of antibody uses and applications. |
| Discussion Leaders: Paul Parren (Genmab B.V., The Netherlands) and Falk Nimmerjahn (University of Erlangen-Nuremberg, Germany) |
9:00 am - 9:25 am | Peter Sun (National Institute of Allergy and Infectious Diseases, NIH, USA) "Pentraxins, IgA and FcαRI" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Leo James (Medical Research Council, United Kingdom) "Intracellular Neutralization and Innate Immune Activation by the Cytosolic Antibody Receptor TRIM21" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:40 am | Coffee Break |
10:40 am - 11:05 am | Brian Sutton (King's College London, United Kingdom) "The Dynamics of IgE and Its Receptor Interactions" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:25 am | Anja Lux (University of Erlangen-Nurnberg, Germany) "Impact of IgG Glycosylation on the Inflammatory Activity of IgG" |
11:25 am - 11:30 am | Discussion |
11:30 am - 11:40 am | Kristi Baker (University of Alberta, Canada) "FcRn and Polymorphic FCGR2A Variants Co-Operatively Drive Immune-Complex Mediated Diseases" |
11:40 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Frank Beurskens (Genmab, The Netherlands) "Functional Aspects of Antigen- and Fc-Dependent IgG Hexamer Formation" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Jan Terje Andersen (Oslo University Hospital / University of Oslo, Norway) "Human IgG3 Is a Superior Mediator of Intracellular Anti-Viral Immunity" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
3:00 pm - 4:00 pm | Power Hour |
| The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring. |
| Organizers: Erica Ollmann Saphire (The Scripps Research Institute, USA) and Jeanette Leusen (University Medical Center Utrecht, The Netherlands) |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | The Functionality of Antibodies and the Receptors Through Which They Operate: Translation to Therapeutic Applications |
| This session aims not to solely focus on Fc-gamma receptors/FcRn and IgG, but also on what other isotypes and recently identified receptors (e.g. TRIM21, FcRL) teach to explore new avenues of antibody uses and applications. |
| Discussion Leaders: Paul Parren (Genmab B.V., The Netherlands) and Falk Nimmerjahn (University of Erlangen-Nuremberg, Germany) |
7:30 pm - 7:55 pm | Jonathan Davis (Bristol-Myers Squibb, USA) "Symmetric and Asymmetric Synergy Join to Drive Potency in a Novel Biologic HIV-1 Entry Inhibitor" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | David Szymkowski (Xencor, Inc., USA) "Engineering Fc Affinity for FcgammaRIIb to Generate Therapeutic Antibodies with Novel Mechanisms of Action" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:05 pm | James Ernst (Genentech, USA) "A Novel Tissue Specific Agonist of the FGF21 Pathway for the Treatment of Type II Diabetis" |
9:05 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Gestur Vidarsson (Sanquin Research, The Netherlands) "Immune Modulation Through Glycan-Coding of IgG: Biochemical Decryption of IgG-Responses Found Against Red Blood Cells and Platelets" |
9:25 pm - 9:30 pm | Discussion |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Development and Mechanisms of Pathogenic or Protective Antibodies |
| This session aims to focus on mechanisms and generation of pathogenic or protective antibodies and to explore features of antibodies involved in disease or protection beyond antigen specificity such as glycosylation or isotype and subclass. |
| Discussion Leader: Antonio Lanzavecchia (Institute for Research and Biomedicine, Università della Svizzera Italiana, Switzerland) |
9:00 am - 9:25 am | Antonio Lanzavecchia (Institute for Research and Biomedicine, Università della Svizzera Italiana, Switzerland) "A New Mechanism of Antibody Diversification" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Erica Ollmann Saphire (The Scripps Research Institute, USA) "Antibodies Against Ebola Virus: Results of the Viral Hemorrhagic Fever Immunotherapeutic Consortium" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:40 am | Coffee Break |
10:40 am - 11:05 am | Louis Weiner (Georgetown University, USA) "Functional Genomic Screening to Identify Tumor-Based Molecular Determinants of Anti-Cancer Immune Responses" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:25 am | William Faison (Luxembourg Institute of Health, Luxembourg) "Anchored Lineage Reconstruction Reveals B Cell Repertoire Convergence on Measles Virus Hemagglutinin Protein in Three Independent Vaccination Cohorts" |
11:25 am - 11:30 am | Discussion |
11:30 am - 11:40 am | Alex Sevy (Vanderbilt University, USA) "Generating Broadly Neutralizing Antibodies via Computational Design" |
11:40 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Amandeep Sangha (Vanderbilt University, USA) "Discovery and Design of Human Antibodies to Broadly Neutralize Filoviruses" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Kaitlin Sawatzki (Boston University, USA) "Non-Specific Activation of Autoreactive B Cells After Anthrax Vaccination Delays Protection" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Nancy Sullivan (National Institutes of Health, USA) "Protection of Macaques Against Ebola Virus Infection by a Single, Potently Neutralizing Antibody and Molecular Mechanism of Recognition" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Unique Therapeutic Vistas in Antibody Engineering: Bispecifics |
| This session aims to focus on novel and explorative preclinical and clinical applications of antibody modifications using novel bispecifics and multispecific technologies. |
| Discussion Leader: Paul Carter (Genentech, Inc., USA) |
7:30 pm - 7:55 pm | Antonin De Fougerolles (Ablynx NV, Belgium) "Nanobodies as a Versatile and Clinically Validated Drug Platform" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Teemu Junttila (Genentech Inc., USA) "Antitumor Efficacy of a Bispecific Antibody that Targets HER2 and Activates T Cells" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:05 pm | Michel Sadelain (Memorial Sloan Kettering Cancer Center, USA) "CAR T Cell Engineering" |
9:05 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Aran Labrijn (Genmab, The Netherlands) "Bispecific Mouse Antibodies for Pre-Clinical Studies Generated by Controlled Fab-Arm Exchange" |
9:25 pm - 9:30 pm | Discussion |
Thursday |
7:30 am - 8:30 am | Breakfast |
8:30 am - 9:00 am | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
9:00 am - 12:30 pm | Co-Opting Antibodies as a Delivery Vehicle |
| This session aims to focus on "Co-Opting antibodies as a Delivery Vehicle" (on novel and explorative preclinical and clinical applications of antibody modifications associated with antibody drug conjugates, cytokines or other approaches). |
| Discussion Leader: John Lambert (ImmunoGen, Inc., USA) |
9:00 am - 9:25 am | Ambily Abraham (Indian Institute of Science, India) "Plant Virus Based Nanocarriers for Delivery of Therapeutic Antibodies" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Christian Klein (Roche Innovation Center Zurich, Switzerland) "Antibody-Based Targeted Cancer Immunotherapy" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:40 am | Coffee Break |
10:40 am - 11:05 am | Xiuxia Sun (ImmunoGen, Inc., USA) "Using Antibodies to Deliver Cytotoxic Agents into Cancer Cells" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:40 am | K. Dane Wittrup (David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, USA) "Anti-Tumor Antibodies as Immunotherapy - Beyond ADCC to Adaptive T Cell Responses" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:15 pm | Nimesh Gupta (National Institute of Immunology, India) "Navigating Through The Materno-Fetal Interface to Establish Antigen-Specific Tolerance in Fetal Life" |
12:15 pm - 12:25 pm | Discussion |
12:25 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Therapeutic Challenges and Opportunities in the Application of Antibodies to Modifying Disease |
| This session aims to consider novel, ground-breaking opportunities for antibody therapies as in immune oncology or infectious diseases (e.g. HIV or Ebola). |
| Discussion Leader: Louis Weiner (Georgetown University, USA) |
7:30 pm - 7:55 pm | Sergio Quezada (University College London, United Kingdom) "Immune Check Point Inhibition" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Paul Parren (Genmab B.V., The Netherlands) "Molecular Aspects of C1-Antibody Interactions" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 8:50 pm | Nicolas Fischer (Novimmune, Switzerland) "Selective Inhibition of the Immuno-Oncology Target CD47 Mediated by a Specific Antibody" |
8:50 pm - 8:55 pm | Discussion |
8:55 pm - 9:05 pm | Llewelyn Lao (XOMA, USA) "Antibody Engineering of XMetD to Produce XOMA129, a Rapidly Acting Insulin Receptor Modulator that Is a Potential Therapeutic Molecule for Treating Iatrogenic Hypoglycemia" |
9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:20 pm | General Discussion |
9:20 pm - 9:30 pm | Closing Remarks |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |