Antibodies as Change Agents – Biological Diversity and Synergies

Antibodies are multifaceted proteins that are capable of an array of important functions. They have a major part to play in immune protection against invading pathogens, and have a central role in the protective response induced by vaccination. Our understanding of the critical pathophysiology of antibodies in clinically important inflammatory and autoimmune diseases, is increasingly applied to the design of highly effective therapeutic molecules. Indeed, antibodies represent the largest class of biologics that are currently in development or approved by major pharmaceutical regulatory organizations for the treatment of an amazingly broad variety of diseases.

The 2018 Antibody Biology and Engineering Gordon Conference will present in-depth coverage of recent advances in this exciting field, in an informal setting designed to maximize interaction. The conference will bring together leading researchers from academia and the biopharmaceutical industry, providing an ideal opportunity for top researchers from around the world to present and discuss cutting-edge data.

Fusing new developments in basic science with high-impact translational and clinical research, the meeting will provide a stimulating program featuring an international mix of established and upcoming researchers. A major emphasis will be on mechanisms of antibody action in health and disease. Key topics will include antibody diversity, structure-function relationships, immunoglobulin effector function, antibody synergies and cross talk, recruitment of host factors and alternative antibody-dependent responses. Significant attention will also be focused on preclinical evaluation of therapeutic antibody candidates for indications including infectious disease, autoimmune disease and immuno-oncology.

The GRC will be preceded by a Gordon Research Seminar (GRS). The Antibody Biology and Engineering GRS is designed to further facilitate the participation of graduate students and postdoctoral researchers. Planned by, and for trainees, the GRS provides an opportunity for junior researchers to present seminars and posters in a supportive, interactive environment.