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Antibody Biology and Engineering

Gordon Research Conference

Antibody-Producing Cells and Repertoires: Function and Applications of Engineered Antibodies, Scaffolds and Multispecifics

March 17 - 22, 2024

Chairs

and

Vice Chair

Renaissance Tuscany Il Ciocco

Via Giovanni Pascoli

Lucca (Barga), Lucca, Italy

Venue and Travel Information

Conference Description

ATTENTION: The GRC bus picks up and drops off at the Florence Airport (FLR) only. GRC no longer has bus service to / from the Pisa Airport.

The Antibody Biology and Engineering GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. The conference program includes a diverse range of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field. The conference is five days long and held in a remote location to increase the sense of camaraderie and create scientific communities, with lasting collaborations and friendships. In addition to premier talks, the conference has designated time for poster sessions from individuals of all career stages, and afternoon free time and communal meals allow for informal networking opportunities with leaders in the field.

The 2024 Antibody Biology and Engineering Conference and Seminar will bring together international scientists from across academia and industry who are leading investigations into how antibodies, a key element of our immune defense system, bring about their protective effects. The meeting will allow both established and junior researchers, mostly PhDs and MD-PhDs and graduate students, to present and discuss their latest findings, develop ideas, forge new contacts, and initiate collaborations. Together, they will pave the way to new and better treatments for many common disorders including inflammatory conditions such as immune-mediated and autoimmune disorders, major infections, and cancer. Antibodies and antibody-expressing engineered cells (ex: CAR-T cells) in particular have been at the center of the most promising clinical results of the last decade in oncology and inflammatory diseases.

POSTER SUBMISSION DEADLINE: JANUARY 31, 2024

Related Meeting

This GRC will be held in conjunction with the "Antibody Biology and Engineering" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm	Keynote Session: Antibodies 2.0 Discussion Leader:
7:40 pm - 7:50 pm	Introduction by Discussion Leader
7:50 pm - 8:30 pm	"Design of Antibody Therapeutics With Engineered Multispecificity"
8:30 pm - 8:40 pm	Discussion
8:40 pm - 9:20 pm	"Cell-Penetrating Peptide-Mediated Internalisation of Antibodies for Radioimmunotherapy of Pancreatic Cancer"
9:20 pm - 9:30 pm	Discussion
Monday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Anti-Infectious Repertoires and Therapeutics Discussion Leaders: and
9:00 am - 9:05 am	Introduction by Discussion Leader
9:05 am - 9:30 am	"Evolution of Human B Cell Memory Over Time and Repeated Antigenic Encounters"
9:30 am - 9:40 am	Discussion
9:40 am - 10:05 am	"Antibody Repertoire Analysis: A Novel Route to Target Discovery"
10:05 am - 10:15 am	Discussion
10:15 am - 10:45 am	Coffee Break
10:45 am - 11:10 am	"Complexity Matters: How Natural Antibodies Eliminate Complex Pathogens"
11:10 am - 11:20 am	Discussion
11:20 am - 11:45 am	"Human Antibody Repertoire of SARS-CoV-2 XBB1.5 Booster Immunization"
11:45 am - 11:55 am	Discussion
11:55 am - 12:05 pm	"High-Throughput Characterization of Human anti-PfRH5 Antibodies Reveals a Potent Public Antibody Clonotype Against Blood-Stage Malaria"
12:05 pm - 12:10 pm	Discussion
12:10 pm - 12:20 pm	"Stalk Antibody-Mediated Broad Protection Against Influenza Viruses"
12:20 pm - 12:25 pm	Discussion
12:25 pm - 12:30 pm	General Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
3:00 pm - 4:00 pm	The GRC Power Hour™ The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring. Organizer:
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Antibody Delivery Discussion Leaders: and
6:00 pm - 6:05 pm	Introduction by Discussion Leader
6:05 pm - 6:30 pm	"A TREM2-Activating Antibody with a Blood–Brain Barrier Transport Vehicle Enhances Microglial Metabolism in Alzheimer’s Disease Models"
6:30 pm - 6:35 pm	Discussion
6:35 pm - 6:55 pm	"Bypassing the Blood Brain Barrier: Exploiting CNS Penetrant AAV Vectors for Localised Biologics Production and Activity"
6:55 pm - 7:00 pm	Discussion
7:00 pm - 7:10 pm	"A Non-Invasive Subunit Vaccine Technology Targeting FcRn Induces Protective Mucosal and Systemic Antibody Immunity in Mouse Models"
7:10 pm - 7:15 pm	Discussion
7:15 pm - 7:25 pm	"TrogoTACs: Bispecific Chimeras for Targeted Protein Transfer"
7:25 pm - 7:30 pm	Discussion
7:30 pm - 7:40 pm	"Engineering Trojan Horse Nanoparticles for Targeted Endosomal Delivery of Viral Fusion Inhibitors"
7:40 pm - 7:45 pm	Discussion
7:45 pm - 7:55 pm	"The Pathomechanisms of MuSK Antibodies and How They Can Be Used As Therapeutics"
7:55 pm - 8:00 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Tuesday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Group Photo
9:00 am - 12:30 pm	Abs Formats for Cancer and Autoimmunity Discussion Leaders: and
9:00 am - 9:05 am	Introduction by Discussion Leader
9:05 am - 9:30 am	"Natural Killer Cell Engagers"
9:30 am - 9:40 am	Discussion
9:40 am - 10:05 am	"Engineering More Stable Antibody Drug Conjugates to Address Platform Toxicities is Conceptually Simple but Hard to Translate to the Clinic"
10:05 am - 10:15 am	Discussion
10:15 am - 10:45 am	Coffee Break
10:45 am - 11:10 am	"A Novel Bispecific to Target the Brain Tumor Microenvironment"
11:10 am - 11:20 am	Discussion
11:20 am - 11:45 am	"Modulation of IgG Effector Functions by Fc Glycosylation"
11:45 am - 11:55 am	Discussion
11:55 am - 12:05 pm	"Mesothelin-Targeted Nanobody-Drug Conjugates for the Treatment of Pancreatic Cancer"
12:05 pm - 12:10 pm	Discussion
12:10 pm - 12:20 pm	"A Bispecific T-Cell Engager (BiTE) Targeting CD19 and CD3 is Arresting Disease Progression in a Mouse Model of Autoimmune Blistering Disease"
12:20 pm - 12:25 pm	Discussion
12:25 pm - 12:30 pm	General Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Ig Classes and Half Life Discussion Leader:
6:00 pm - 6:25 pm	"The Unique Properties of IgG4 and its Roles in Health and Disease"
6:25 pm - 6:35 pm	Discussion
6:35 pm - 7:00 pm	"Development of Anti-FcRn Antibodies for Blocking FcRn in Autoimmune Diseases"
7:00 pm - 7:10 pm	Discussion
7:10 pm - 7:25 pm	"Distinct Transport Properties of the Two Ligands of FcRn: From Biology to Therapeutic Implication"
7:25 pm - 7:30 pm	Discussion
7:30 pm - 7:40 pm	"Elevating Fc Effector Functions by Exploiting the Natural Amino-Acid Sequence Variation in IgG Subclasses"
7:40 pm - 7:45 pm	Discussion
7:45 pm - 7:55 pm	"Two Faces of IgM: Distinct Molecular Features, Clonalities, and Specificities When Present in Circulation or Secretions"
7:55 pm - 8:00 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Engineering Abs for Enhanced Function Discussion Leaders: and
9:00 am - 9:05 am	Introduction by Discussion Leader
9:05 am - 9:30 am	"TCR-Mimic Nanobody-Based Bispecific T Cell Engager for Tumor Immunotherapy"
9:30 am - 9:40 am	Discussion
9:40 am - 10:05 am	"The Evolution of Antibody Discovery in Veterinary Medicine"
10:05 am - 10:15 am	Discussion
10:15 am - 10:45 am	Coffee Break
10:45 am - 11:10 am	"Mutually Dependent Antibody Pairs that Selectively Act on Cells Co-Expressing Two Surface Antigens"
11:10 am - 11:20 am	Discussion
11:20 am - 11:45 am	"Energy-Based Ab Improvement"
11:45 am - 11:55 am	Discussion
11:55 am - 12:05 pm	"Investigating the Novel "X" Trispecific T Cell Engaging Antibody for an Enhanced Anti-Tumor Response"
12:05 pm - 12:10 pm	Discussion
12:10 pm - 12:15 pm	General Discussion
12:15 pm - 12:25 pm	"A Tetravalent (2+2) Bispecific Antibody Format with Excellent Functionality and IgG-Like Stability, Pharmacology and Developability Properties"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Innovative Technologies for B Cell and Antibody Identification Discussion Leaders: and
6:00 pm - 6:05 pm	Introduction by Discussion Leader
6:05 pm - 6:30 pm	"High-Throughput Profiling of Antigen-Specific Antibody Secreting Cells"
6:30 pm - 6:40 pm	Discussion
6:40 pm - 7:05 pm	"The Use of Microfluidics to Identify Rare B Cells Targeting Infectious Pathogens"
7:05 pm - 7:15 pm	Discussion
7:15 pm - 7:25 pm	"Conformational Tuning of Antibody Fab-Arms Facilitates Immune Agonist Activity"
7:25 pm - 7:30 pm	Discussion
7:30 pm - 7:40 pm	"Modified Self-Amplifying RNA for In situ Antibody Production"
7:40 pm - 7:45 pm	Discussion
7:45 pm - 7:55 pm	"Insights Into the In Vivo Mode of Action of Mono and Bispecific Antibodies Through Kinetic Analysis of Affinity and Avidity"
7:55 pm - 8:00 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Thursday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Business Meeting Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm	Computational and Systems Analyses Discussion Leader:
9:00 am - 9:05 am	Introduction by Discussion Leader
9:05 am - 9:30 am	"Discovery and Characterization of CD28 Multispecific Antibodies for Treatment of Solid Tumors"
9:30 am - 9:40 am	Discussion
9:40 am - 10:05 am	"Dissecting Antibody Functions in Tuberculosis"
10:05 am - 10:15 am	Discussion
10:15 am - 10:45 am	Coffee Break
10:45 am - 11:10 am	"Antibody Feedback Shaping Antibody Diversity"
11:10 am - 11:20 am	Discussion
11:20 am - 11:45 am	"Electron Microscopy and Computational Approaches to Vaccine Design"
11:45 am - 11:55 am	Discussion
11:55 am - 12:05 pm	"Mutability and Hypermutation Antagonize Immunoglobulin Codon Optimality"
12:05 pm - 12:10 pm	Discussion
12:10 pm - 12:20 pm	"Guiding Human Antibody Affinity Optimization by Understanding Rare Mutations Suggested by Complex Evolutionary Rules"
12:20 pm - 12:25 pm	Discussion
12:25 pm - 12:30 pm	General Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Vaccination Shapes B and Ab Responses Discussion Leaders: and
6:00 pm - 6:05 pm	Introduction by Discussion Leader
6:05 pm - 6:30 pm	"The Past, Present and Future of Antiviral Monoclonal Antibodies"
6:30 pm - 6:40 pm	Discussion
6:40 pm - 7:05 pm	"Human Antibodies for Emerging Infectious Diseases"
7:05 pm - 7:15 pm	Discussion
7:15 pm - 7:25 pm	"Interrogation of Human Monoclonal Antibodies Induced by Meningococcus B Vaccination to Identify Cross-Protective Antigens Against Gonococcus"
7:25 pm - 7:30 pm	Discussion
7:30 pm - 7:40 pm	"An Engineered Hyperglycosylated Immunogen to Epitope-Focus Anti-Neuraminidase Humoral Immunity"
7:40 pm - 7:45 pm	Discussion
7:45 pm - 7:55 pm	"A Chimeric HA UIV Elicits Multi-Pronged Polyclonal Antibody Responses to Conserved Head and Stem Epitopes on HA"
7:55 pm - 8:00 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

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Conference History Antibody Biology and Engineering (GRS)

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