| SUNDAY |
| 4:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 7:35 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:35 pm - 7:40 pm | Welcome and overview of the meeting by Dr. Miller |
| 7:40 pm - 9:30 pm | MCS: Where are we now? |
| Discussion Leaders: James Kirklin, MD (UAlabama-Birmingham) and Michael Acker, MD (U Penn) |
| 7:40 pm - 8:10 pm | James Kirklin (UAB)
"Current data from the INTERMACS Registry. What have we learned thus far? What can it provide in the future??" |
| 8:10 pm - 8:25 pm | Discussion |
| 8:25 pm - 9:00 pm | Michael Acker (U of Penn)
"Industry Update: Current devices, volumes and outcomes of devices now in clinical trial" |
| 9:00 pm - 9:30 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Group Photo |
| 9:00 am - 12:30 pm | Putting an END to VAD complications |
| Discussion Leaders: Mariell Jessup, MD (U Penn) and Randall Starling, MD (Clev Clinic) |
| 9:00 am - 9:15 am | Catherine Manno, MD (Children's Hosp of Penn)
"The approach to coagulopathy and bleeding with VADs" |
| 9:15 am - 9:30 am | Anne Marie Schmidt (Columbia University)
"Novel Factor IX Inhibitor to prevent post operative bleeding" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 9:55 am | Julian Munoz, MD (U Alabama-Birmingham)
"The critical role of nutrition in Post VAD infection" |
| 9:55 am - 10:05 am | Discussion |
| 10:05 am | Coffee Break |
| 10:30 am - 10:50 am | Ronald Lazar, MD (Columbia University)
"Neurological Injury post LVAD: Observations and lessons learned" |
| 10:50 am - 11:00 am | Discussion |
| 11:00 am - 11:20 am | Robert Kormos (U of Pittsburgh)
"Strategies to minimize RV Failure post LVAD" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Hassan Ibrahim (U Minnesota)
"Putting an end to post-VAD renal failure; risk factors and new strategies" |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:30 pm | Open Discussion on other novel strategies to end complications |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session (1) - New Ideas and New Technology for MCS: Phase I Ideas |
| Moderators: Bud Frazier (Texas Heart Institute) and Mark Slaughter (Christ Hospital) |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Biologic Responses to MCS |
| Discussion Leader: Guillermo Torre (Methodist Hospital, Cornell University) |
| 7:30 pm - 7:50 pm | Silviu Itescu (Columbia University)
"Immune activation and responses with use of LVADs: clinical implications" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | George Weiselthaler (University of Vienna)
"Anti-aggregation or anti-coagulation: What do we need to prevent VAD thrombosis" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Guillermo Torre (Methodist Hospital)
"Molecular responses to mechanical unloading: What have we learned and what does it mean?" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Dan Burkhoff (Columbia)
"Myocardial responses to pulsatile vs. continuous flow pumps-clinical implications" |
| 9:20 pm - 9:30 pm | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Designing the next clinical trials |
| Discussion Leaders: Leslie Miller (Wash Hosp Center/GT) and Eric Rose (Columbia University) |
| 9:00 am - 9:20 am | Annetine Gelijns (Columbia University)
"Trial design options: Pros and Cons of OPC's vs. RCT" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Wayne Levy (U Washington)
"Risk Stratification for survival with medical therapy: The key to a randomized trial" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:30 am | Coffee Break |
| 10:30 am - 10:50 am | Keith Aaronson (U Michigan)
"Criteria for HF survival: Can we reliably predict patients with 50% 1 yr mort?" |
| 10:50 am - 11:00 am | Discussion |
| 11:00 am - 11:20 am | Joseph Rogers (Duke University)
"Selection of End Points for VAD trials: Survival, Function, QOL??" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Mariell Jessup (U Penn)
"What outcomes will it take to increase referrals for VAD therapy: The perspective of the HF community" |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:30 pm | Open Discussion on New Trial Design |
| 12:30 pm | Lunch |
| 1:30 pm - 6:00 pm | Free Time |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Regulatory, Funding, and Industry limitations to new trial design and expansion of the field |
| Discussion Leaders: Robert Kormos (U Pittsburgh) and Bram Zuckerman (FDA) |
| 7:30 pm - 7:45 pm | Bram Zuckerman (FDA)
"Safety and Efficacy: What does that mean for the field of MCS in 2008 and beyond" |
| 7:45 pm - 7:55 pm | Discussion |
| 7:55 pm - 8:10 pm | Peter Crosby (Ventrassist)
"Industry's view of the playing field: Shifting sands or fixed target?" |
| 8:10 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:30 pm | James Lee (World Heart)
"Reliability Testing for Devices: Current Guidelines" |
| 8:30 pm - 8:40 pm | Discussion |
| 8:40 pm - 8:55 pm | Jim Long (LDS Hospital)
"What is holding up progress in this field, and how do we solve it" |
| 8:55 pm - 9:05 pm | Discussion |
| 9:05 pm - 9:30 pm | Open Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Innovations in Device Design: Looking into the Future |
| Discussion Leaders: John Watson, PhD (UCSD) and J. Timothy Baldwin, PhD (NHLBI) |
| 9:00 am - 9:20 am | James Anderson, PhD (Case Western Reserve)
"Novel Hypothesis for Quantum reduction in Adverse Events" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Ravi Birla, PhD (U of Michigan)
"A Better Tomorrow for HF Patients: Assisted Circulation Through Tissue Engineering" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:30 am | Coffee Break |
| 10:30 am - 10:50 am | Mark Gartner, PhD (Ension, Inc)
"Designing to Assist the Circulation: New bioactive, infection resistant, anti-thrombotic, platelet resistant biomaterials for LVADs, and More" |
| 10:50 am - 11:00 am | Discussion |
| 11:00 am - 11:20 am | William Wagner, PhD (U of Pittsburgh)
"Injectable Repair Therapy" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Prabhakar Bandaru (UCSD)
"Enabling highly efficient heat-energy conversion, through Si/SiGe Quantum Well Thermoelectrics" |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:20 pm | Doris Taylor, PhD (U of Minnesota)
"New Hearts from bioengineering" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session (2) |
| Moderators: James Long, MD (LDS Hospital), Mike Acker, MD (U of Penn) and Karen Maye-Newman (UCSDS) |
| 6:00 pm | Dinner |
| 7:30 pm - 8:00 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
| 8:00 pm - 9:30 pm | The future of LVAD therapy |
| Discussion Leaders: Jane Reedy (Heartware) and John Woodard (Ventrassist) |
| 8:00 pm - 8:20 pm | Robert Kormos (U Pittsburgh)
"A simple, effective RVAD: Still the missing link to optimal MCS" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Peter Wearden (U Pittsburgh)
"Pediatric Mechanical Circulatory Support: State of the Art" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Eric Rose, MD (Columbia University)
"Mech Circ Support: Innovations and Future Directions" |
| 9:20 pm - 9:30 pm | Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | RECOVERY: How do we get there? |
| Discussion Leaders: Frank Pagani, MD (U Michigan) and Doris Taylor, PhD (U Minnesota) |
| 9:00 am - 9:20 am | Doris Taylor (U Minnesota)
"Cell Therapy for Heart Failure: What have we learned and what is the most promising cell and route now and in the future?" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Emma Birks (Harefield, London UK)
"Drug Therapy for myocardial recovery: Lessons Learned" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:30 am | Coffee Break |
| 10:30 am - 10:50 am | Jennifer Hall (U Minnesota)
"Recovery vs Remodeling: Molecular Signatures, and Lessons Learned" |
| 10:50 am - 11:00 am | Discussion |
| 11:00 am - 11:20 am | Roger Hajjar
"Gene Therapy for HF: Hype or Hope??" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Ben Sun (Ohio State)
"Reloading the Ventricle: Is this the missing link??" |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:30 pm | Open Discussion on Recovery |
| 12:30 pm | Lunch |
| 1:30 pm - 6:00 pm | Free Time |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Temporary MCS: The emerging role of percuataneous support devices for Recovery of Acute HF |
| Discussion Leaders: John Watson, PhD (U California, San Diego) and Leslie Miller, MD (Wash Hosp Center/GT) |
| 7:30 pm - 7:45 pm | Reynolds Delgado (Texas Heart Institute)
"The emerging role of percutaneous MCS: The Tandem Heart Experience" |
| 7:45 pm - 7:50 pm | Discussion |
| 7:50 pm - 8:05 pm | Mark Anderson, MD (Robert Wood Johnson University)
"Use of the Impella Pump for temporary percutaneous MCS" |
| 8:05 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:25 pm | Ranjit John (U Minnesota)
"Use of the Levitronix Pump for Temporary Support and Bridge to a Bridge" |
| 8:25 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:40 pm | Stephen Boyce (Washington Hospital Center)
"The future of surgical temporary MCS" |
| 8:40 pm - 8:45 pm | Discussion |
| 8:45 pm - 9:15 pm | Open Discussion on Percutaneous MCS |
| 9:15 pm - 9:30 pm | Leslie Miller and John Watson
"Wrap of the Meeting: What are the Goals for 2009 and 2012????" |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |
