| Sunday |
| 4:00 pm - 8:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:40 pm - 9:30 pm | Mechanically
Assisted Circulation: Past, Present and Future |
| The focus of this session will include discussions of the most critical advances in mechanically assisted circulation and the greatest needs for the therapy in the next five years. |
| Discussion Leaders: James Long (Integris Advanced Cardiac Care, USA) and John Watson (University of California, San Diego, USA) |
| 7:40 pm - 7:50 pm | Opening Remarks |
| 7:50 pm - 8:10 pm | George Wieselthaler (University of California, San Francisco, USA)
"The Five Most Critical Advances in Mechanically Assisted Circulation" |
| 8:10 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Michael Acker (University of Pennsylvania Hospital, USA)
"The Five Greatest Needs in Mechanically Assisted Circulation" |
| 8:50 pm - 9:10 pm | Discussion |
| 9:10 pm - 9:30 pm | General Discussion |
| Monday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Improving Device Performance: Enhancing Durability and Reducing Blood Trauma |
| The focus of this session will include discussions of novel approaches to energy supply, computer simulation of coagulation and blood trauma, innovations in blood contacting biomaterials and creating biological blood contacting surfaces. |
| Discussion Leader: Francis Pagani (University of Michigan, USA) |
| 9:00 am - 9:30 am | Castro Laicer (Giner, Inc., USA)
"Novel Approaches to Energy Supplies" |
| 9:30 am - 10:00 am | Discussion |
| 10:00 am - 10:30 am | Coffee Break |
| 10:30 am - 10:50 am | David Ku (Georgia Institute of Technology, USA)
"Computer Simulation of Coagulation and Blood Trauma" |
| 10:50 am - 11:10 am | Discussion |
| 11:10 am - 11:30 am | William Wagner (University of Pittsburgh, USA)
"Innovations in Blood Contacting Biomaterials" |
| 11:30 am - 11:50 am | Discussion |
| 11:50 am - 12:10 pm | Hardean Achneck (Hemostemix Inc., USA)
"Creating Biological Blood Contacting Surfaces" |
| 12:10 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:30 pm | Free Time |
| 4:30 pm - 6:00 pm | Poster Session |
| 6:00 pm - 8:00 pm | The Challenges of Mechanically Assisted Circulation in Special Populations |
| The focus of this session will include discussions of patient cohorts inadequately addressed with current technologies, restrictive cardiomyopathy and alterations in myocardial biology following VAD support. |
| Discussion Leaders: Francisco Arabia (Cedars-Sinai Medical Center, USA) and Massimo Griselli (Newcastle upon Tyne Hospitals, United Kingdom) |
| 6:00 pm - 6:20 pm | Daniel Burkhof (HeartWare / Columbia University, USA)
"Computer Simulations of MCS in Restrictive Cardiomyopathies" |
| 6:20 pm - 6:40 pm | Discussion |
| 6:40 pm - 7:00 pm | Nir Uriel (University of Chicago, USA)
"Integrated, Multi-Modality Assessment of RV Function" |
| 7:00 pm - 7:20 pm | Discussion |
| 7:20 pm - 7:40 pm | Timothy Baldwin (National Heart, Lung, and Blood Institute, USA)
"NHLBI Programs to Evaluate MCS in Novel Populations: PUMPKIN and REVIVE IT" |
| 7:40 pm - 8:00 pm | Discussion |
| 8:00 pm | Dinner |
| Tuesday |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Group Photo |
| 9:00 am - 12:30 pm | Innovative Circulatory Support Device Designs and Operating Modes |
| The focus of this session will include discussions of the biological changes associated with continuous flow pumps and the importance of circulatory pulsatility, physiological pacemaker sensors and their potential applications in mechanical circulatory support, innovative strategies in mechanical blood pumps and the use of rotary pumps for biventricular support. |
| Discussion Leaders: Karen May-Newman (San Diego State University, USA) and Mark Slaughter (University of Louisville, USA) |
| 9:00 am - 9:30 am | Valluvan Jeevanandam (University of Chicago, USA)
"The Importance of Pulse Pressure: Making a Case for Counterpulsation" |
| 9:30 am - 10:00 am | Discussion |
| 10:00 am - 10:30 am | Coffee Break |
| 10:30 am - 10:50 am | Andreas Arndt (Biotronik SE & Co.KG, Germany)
"Physiological Pacemaker Sensors and Their Application to MCS" |
| 10:50 am - 11:10 am | Discussion |
| 11:10 am - 11:30 am | JoAnn Lindenfeld (Vanderbilt University, USA)
"Monitoring Peri-Operative Anticoagulation Status: Implications for Clinical and Device Management" |
| 11:30 am - 11:50 am | Discussion |
| 11:50 am - 12:10 pm | Daniel Timms (BiVACOR Inc., USA)
"Using Rotary Pumps for Biventricular Support" |
| 12:10 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:30 pm | Free Time |
| 4:30 pm - 6:00 pm | Poster Session |
| 6:00 pm - 8:00 pm | New Approaches to Manufacturing and Managing Therapies for Advanced Heart Failure |
| The focus of this session will include discussions of designing a less expensive VAD, using 3-D printers to create artificial organs and optimizing device management to improve patient functionality. |
| Discussion Leaders: Timothy Baldwin (National Heart, Lung, and Blood Institute, USA) and Mariell Jessup (University of Pennsylvania, USA) |
| 6:00 pm - 6:20 pm | Trevor Snyder (Integris Baptist Medical Center, USA)
"Building and Selling a $5000 VAD: Barriers and Opportunities" |
| 6:20 pm - 6:40 pm | Discussion |
| 6:40 pm - 7:00 pm | Sean Murphy (Wake Forest Institute for Regenerative Medicine, USA)
"Using 3-D Printers to Create Artificial Organs" |
| 7:00 pm - 7:20 pm | Discussion |
| 7:20 pm - 7:40 pm | Christopher Hayward (St. Vincent's Hospital, Australia)
"Device Management to Optimize Patient Activity" |
| 7:40 pm - 8:00 pm | Discussion |
| 8:00 pm | Dinner |
| Wednesday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Adverse Events in Assisted Circulation: Developing a Structured Framework for Identification and Mitigation |
| The focus of this session will include discussions of integrated problem solving, predicting adverse events in VADS, imaging thrombus in situ and the challenges of assessing neurological injury in pediatric patients. |
| Discussion Leaders: Robert Kormos (University of Pittsburgh Medical Center, USA) and Clyde Yancy (Northwestern University, USA) |
| 9:00 am - 9:30 am | Tim Kelley (WL Gore & Associates, Inc., USA)
"Integrated Problem Solving" |
| 9:30 am - 10:00 am | Discussion |
| 10:00 am - 10:30 am | Coffee Break |
| 10:30 am - 10:50 am | Natasha Loghmanpour (Carnegie Mellon University, USA)
"Predicting Adverse Events in VADs: We Don't Know What We Don't Know but What We Want to Know Is Clear" |
| 10:50 am - 11:10 am | Discussion |
| 11:10 am - 11:30 am | Gregory Lanza (Washington University at St. Louis School of Medicine, USA)
"Imaging Thrombus Inside the VAD In Situ" |
| 11:30 am - 11:50 am | Discussion |
| 11:50 am - 12:10 pm | Rebecca Ichord (Children's Hospital of Pennsylvania, USA)
"Assessing the Subtleties of Neurological Injury: The Challenge of the Pediatric Population" |
| 12:10 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:30 pm | Free Time |
| 4:30 pm - 6:00 pm | Poster Session |
| 6:00 pm - 8:00 pm | Engineering Adverse Events out of Mechanical Blood Pumps |
| The focus of this session will include discussions of the impact of heightened VAD monitoring and its impact on adverse events as well as the impact of partial support devices on adverse events. |
| Discussion Leaders: Paul Mohacsi (University Hospital Bern (Inselspital), Switzerland) and Cumaraswamy Sivathasan (National Heart Centre, Singapore) |
| 6:00 pm - 6:20 pm | Thomas Schloeglhofer (Medical University Vienna, Austria)
"Heightened Monitoring of VAD Performance: Will it Reduce Adverse Events?" |
| 6:20 pm - 6:40 pm | Discussion |
| 6:40 pm - 7:00 pm | Bart Meyns (KU Leuven, Belgium)
"Partial Support Devices: Will They Reduce Adverse Events?" |
| 7:00 pm - 7:15 pm | Discussion |
| 7:15 pm - 7:25 pm | Philipp Aigner (Medical University of Vienna, Austria)
"Washout of the Left Ventricle During LVAD Support and Effectiveness of Intermittent Speed Changes" |
| 7:25 pm - 7:30 pm | Discussion |
| 7:30 pm - 7:40 pm | Megan Jamiolkowski (University of Pittsburgh, USA)
"Visualization and Analysis of Thrombus Formation Within a Defined Crevice Under Flow" |
| 7:40 pm - 7:45 pm | Discussion |
| 7:45 pm - 7:55 pm | Sebastian Jansen (Institute of Applied Medical Engineering, RWTH Aachen University, Germany)
"Ghost Cells for Spatial Resolved In Vitro Hemolysis Measurements" |
| 7:55 pm - 8:00 pm | Discussion |
| 8:00 pm | Dinner |
| Thursday |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am - 9:00 am | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
| 9:00 am - 12:30 pm | Myocardial Recovery: Fundamental Mechanisms and Facilitated Functional Improvement |
| This session will focus on the use of stem cells in myocardial recovery, the impact of varying loading conditions on ventricular recovery and novel biomarkers that predict improvement in left ventricular performance following mechanically assisted circulation. |
| Discussion Leaders: Emma Birks (University of Louisville, USA) and Stavros Drakos (University of Utah, USA) |
| 9:00 am - 9:30 am | Douglas Mann (Washington University at St. Louis, USA)
"Modulating Myocardial Biology to Facilitate Recovery" |
| 9:30 am - 10:00 am | Discussion |
| 10:00 am - 10:30 am | Coffee Break |
| 10:30 am - 10:50 am | Michael Dandel (German Heart Institute, Germany)
"Unloading the Heart: Monitoring and Diagnosing Sustained Myocardial Recovery" |
| 10:50 am - 11:10 am | Discussion |
| 11:10 am - 11:30 am | Craig Selzman (University of Utah, USA)
"Biomarkers Predictive of Recovery" |
| 11:30 am - 11:50 am | Discussion |
| 11:50 am - 12:10 pm | Soon Park (Case Western University, USA)
"Patient Cohorts Inadequately Addressed with Current MCS Technologies" |
| 12:10 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:30 pm | Free Time |
| 4:30 pm - 6:00 pm | Poster Session |
| 6:00 pm - 8:00 pm | Moving MCS Forward in the Next 5 Years |
| The focus of this session will include an analysis of mechanically assisted circulation from an outsider's perspective, the importance of extracellular matrix on myocardial recovery and considerations in valuing innovative technologies. |
| Discussion Leaders: Francesco Moscato (Medical University of Vienna, Austria) and Lynne Warner-Stevenson (Brigham and Women's Hospital, USA) |
| 6:00 pm - 6:20 pm | Cumaraswamy Sivathasan (National Heart Centre, Singapore)
"Mechanically Assisted Circulation in the Asian-Pacific Region: Challenges, Results and Opportunities" |
| 6:20 pm - 6:40 pm | Discussion |
| 6:40 pm - 7:00 pm | James Kirklin (University of Alabama at Birmingham, USA)
"The Challenge of Developing an International MCS Registry" |
| 7:00 pm - 7:20 pm | Discussion |
| 7:20 pm - 7:40 pm | Annetine Gelijns (Mount Sinai Health System, USA)
"Thinking and Rethinking the Value of Innovative Technologies" |
| 7:40 pm - 8:00 pm | Discussion |
| 8:00 pm | Dinner |
| Friday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
