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Assisted Circulation

Gordon Research Conference

Future of Mechanically Assisted Circulatory Support Therapy

May 28 - June 2, 2023

Chairs Kurt A. Dasse and Robert L. Kormos

Vice Chairs Francis D. Pagani and Steven C. Koenig

Waterville Valley

56 Packard's Road

Waterville Valley, New Hampshire, United States

Venue and Travel Information

Conference Description

The Assisted Circulation GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. The conference program includes a diverse range of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field. The conference is five days long and held in a remote location to increase the sense of camaraderie and create scientific communities, with lasting collaborations and friendships. In addition to premier talks, the conference has designated time for poster sessions from individuals of all career stages, and afternoon free time and communal meals allow for informal networking opportunities with leaders in the field.

Related Meeting

This GRC will be held in conjunction with the "Assisted Circulation" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm	MCS: Defining Metrics for Success Discussion Leaders: Scott Silvestry (AdventHealth Transplant Institute, United States) and Jerry Estep (Cleveland Clinic Florida, United States)
7:40 pm - 7:55 pm	Katherine Wood (University of Rochester Medical Center, United States) "Come With Me If You Want to Live: Equivalence in Metrics for Success in Cardiac Transplantation and Durable MCS"
7:55 pm - 8:10 pm	Discussion
8:10 pm - 8:25 pm	James Long (INTEGRIS Advanced Cardiac Care, United States) "What Was, What Is, and What Will Be the New Clinical Definition of Success for the Field of MCS?"
8:25 pm - 8:40 pm	Discussion
8:40 pm - 8:55 pm	Heinrich Schima (Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Austria) "The Opportunities and Risks for Advances in MCS Technology"
8:55 pm - 9:05 pm	Discussion
9:05 pm - 9:20 pm	Marzia Leacche (Corewell Health, United States) "A Collaborative Network for Promoting Minimally Invasive LVAD Implantation: MiniHeart."
9:20 pm - 9:30 pm	Discussion
Monday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Expanding MCS Therapy to Under-Represented Populations Discussion Leader: Kavitha Muthiah (St. Vincent's Hospital, Sydney, Australia)
9:00 am - 9:15 am	Khadijah Breathett (Indiana University, United States) "Barriers and Clinical Trial Access for Minorities and Women."
9:15 am - 9:30 am	Discussion
9:30 am - 9:45 am	K.R. Balakrishnan (MGM Healthcare, India) "Implantable Ventricular Assist Devices: Challenges and Opportunities. Perspective from 'Rest of the World'"
9:45 am - 10:00 am	Discussion
10:00 am - 10:35 am	Group Photo / Coffee Break
10:35 am - 10:55 am	Jennifer Cowger (Henry Ford Hospital, United States) "Recognizing and Avoiding Unintended Biases when Selecting Treatment Options for Patients with Advanced Heart Failure"
10:55 am - 11:10 am	Discussion
11:10 am - 11:25 am	Jerry Estep (Cleveland Clinic Florida, United States) "Outpatient Hemodynamic Monitoring Identifies Ambulatory Heart Failure Patients for VAD Therapy"
11:25 am - 11:40 am	Discussion
11:40 am - 11:55 am	Robert Dowling (The Christ Hospital, United States) "Do We Need to Re-Assess who We Deny the LVAD Option To"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:15 pm	Shelley Hall (Baylor Dallas, United States) "Surviving Cardiogenic Shock Starts with Treatment Decisions: Potential Limitations of Temporary Mechanical Support in Women and Minorities"
12:15 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
3:00 pm - 4:00 pm	The GRC Power Hour™ The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring. Organizers: Priscilla Petit (Inspired Therapeutics LLC, United States) and Aditi Nayak (Brigham and Women’s Hospital / Harvard Medical School , United States)
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Informative Approaches to Support Decision-Making for MCS Discussion Leaders: Tim Baldwin (U.S. Food and Drug Administration, United States) and Angela Lorts (CCHMC, United States)
7:30 pm - 7:55 pm	Valluvan Jeevanandam (University of Chicago, United States) "Innovative Clinical Trial Designs: Applications in the MCS Field"
7:55 pm - 8:10 pm	Discussion
8:10 pm - 8:35 pm	Faezeh Movahedi (University of Pittsburgh, United States) "Limitation of ROC in Evaluation of LVAD Mortality Risk Scores"
8:35 pm - 8:50 pm	Discussion
8:50 pm - 9:15 pm	Kartik Sundareswaran (Abbott, United States) "Evidence Generation for Chronic Mechanical Circulatory Support: Where do we go next?"
9:15 pm - 9:30 pm	Discussion
Tuesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Identifying Optimal MCS Designs with Pre-Clinical Testing Discussion Leaders: Karen May-Newman (San Diego State University, United States) and Bart Meyns (KU Leuven, Belgium)
9:00 am - 9:15 am	Gretel Monreal (University of Louisville, United States) "Pre-Clinical Testing at the UofL Advanced Heart Failure Research Program"
9:15 am - 9:30 am	Discussion
9:30 am - 9:45 am	Diane de Zélicourt (University of Zurich, Switzerland) "Computational Modeling (CFD) in the Assessment of Device Performance in Place of Bench Studies"
9:45 am - 10:00 am	Discussion
10:00 am - 10:15 am	Shaun Gregory (Monash University, Australia) "Harmonizing International Preclinical Approaches to Testing MCS Devices"
10:15 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:15 am	Ellen Roche (Massachusetts Institute of Technology, United States) "Innovative Materials Design for MCS Devices"
11:15 am - 11:30 am	Discussion
11:30 am - 11:45 am	Bettina Wiegmann (Hannover Medical School, Germany) "Biological Approaches to Altering LVAD Surfaces"
11:45 am - 12:00 pm	Discussion
12:00 pm - 12:15 pm	Arman Kilic (Medical University of South Carolina, United States) "Advanced Analytics and Artificial Intelligence and Machine Learning to Assess Clinical Outcomes"
12:15 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Pump Designs, Patient Management and Clinical Trial Designs for Pediatric MCS Discussion Leaders: Harvey Borovetz (University of Pittsburgh, United States) and Christopher Almond (Stanford University, United States)
7:30 pm - 7:45 pm	Peta Alexander (Boston Children’s Hospital and Harvard Medical School, United States) "Computational Frameworks for Optimizing Devices in the Pediatric Populations"
7:45 pm - 8:00 pm	Discussion
8:00 pm - 8:15 pm	Marianne Schmid Daners (ETH Zurich, Switzerland) "Three Highlights from Ten Years of Zurich Heart"
8:15 pm - 8:30 pm	Discussion
8:30 pm - 8:45 pm	Mark Rodefeld (Indiana University, United States) "Cavopulmonary Assist devices for Subpulmonary Support in Univentricular Fontan Circulations: An Update."
8:45 pm - 9:00 pm	Discussion
9:00 pm - 9:15 pm	Christina Vanderpluym (Boston Children's Hospital, United States) "Learning Networks to Transform Pediatric MCS Device Evaluation"
9:15 pm - 9:30 pm	Discussion
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Identifying Opportunities for Improvement in MCS Outcomes Discussion Leader: James Long (INTEGRIS Advanced Cardiac Care, United States)
9:00 am - 9:15 am	Stavros Drakos (University of Utah Health, United States) "Myocardial Recovery: What Have We Learned and Future Directions"
9:15 am - 9:30 am	Discussion
9:30 am - 9:45 am	Sebastian Jansen (RWTH Aachen University, Germany) "Building the SMART LVAD"
9:45 am - 10:00 am	Discussion
10:00 am - 10:15 am	Seraina Dual (KTH Royal Institute of Technology , Sweden) "Preload and Afterload Sensors for Implantable Assistive Technologies"
10:15 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:15 am	Ryan Tedford (Medical University of South Carolina, United States) "Identifying the "At Risk" Right Ventricle: Implications for MCS Timing and Outcomes"
11:15 am - 11:30 am	Discussion
11:30 am - 11:45 am	Melana Yuzefpolskaya (Columbia Univeristy, United States) "Crosstalk Between the Left and Right Ventricles During LVAD Support"
11:45 am - 12:00 pm	Discussion
12:00 pm - 12:15 pm	Katherine Wood (University of Rochester Medical Center, United States) "Quality Improvement in Perioperative Pathways for LVAD surgery"
12:15 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	How Novel Engineering Solutions Can Optimize MCS Devices Discussion Leaders: Changfu Wu (U.S. Food and Drug Administration, United States) and Robert Dowling (The Christ Hospital, United States)
7:30 pm - 7:45 pm	Trevor Snyder (CorWave S.A., France) "Unique Approaches to Generating Pulsatile Flow"
7:45 pm - 7:55 pm	Discussion
7:55 pm - 8:10 pm	Daniel Timms (BiVACOR Inc, United States) "Biventricular Continuous Flow Rotary Support"
8:10 pm - 8:20 pm	Discussion
8:20 pm - 8:35 pm	Chen Chen (CH Biomedical, Inc., China) "Designing MCS Systems"
8:35 pm - 8:45 pm	Discussion
8:45 pm - 9:00 pm	Kevin Bourque (Abbott, United States) "Early Bench and Pre-Clinical Experience with "Smart Pump" Algorithms for Durable Mechanical Circulatory Support"
9:00 pm - 9:10 pm	Discussion
9:10 pm - 9:20 pm	Richard Smalling (Windmill Cardiovascular Systems, United States) "A Synchronized, Pulsatile, Low Power LVAD for Adult and Pediatric Support"
9:20 pm - 9:30 pm	Discussion
Thursday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Business Meeting Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm	Novel Technologies or Biological Approaches to Improve MCS Outcomes Discussion Leaders: Manreet Kanwar (Allegheny General Hospital, United States) and Jennifer Cowger (Henry Ford Hospital, United States)
9:00 am - 9:15 am	Bengt Bern (InvivoPower AB, Sweden) "Inductive Coupling Based TETS: Pros and Cons"
9:15 am - 9:30 am	Discussion
9:30 am - 9:45 am	Michael Zilbershlag (Leviticus Cardio, Israel) "Bailout Vs Redundancy, Wireless LVAD backup alternatives"
9:45 am - 10:00 am	Discussion
10:00 am - 10:30 am	Coffee Break
10:30 am - 10:45 am	Nir Uriel (Columbia University / Weill Cornell Medicine, United States) "Advanced Hemodynamic Assessment in LVAD Therapy: The Role of Pressure Volume Loop and Cardiomems in LVAD Optimization"
10:45 am - 11:00 am	Discussion
11:00 am - 11:15 am	Howard Eisen (Thomas Jefferson University, United States) "Is the future of advanced heart failure therapy mechanical or biological?"
11:15 am - 11:30 am	Discussion
11:30 am - 11:45 am	Pramod Bonde (Yale University, United States) "Autonomous Control of MCS Devices by Continuous Estimation of Cardiac Chamber Size and Volume Estimation"
11:45 am - 12:00 pm	Discussion
12:00 pm - 12:15 pm	Scott Silvestry (AdventHealth Transplant Institute, United States) "What are the Game Changing Technologies for the future of MCS?"
12:15 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Real-World Issues Impacting the Choice for MCS Discussion Leader: Nir Uriel (Columbia University / Weill Cornell Medicine, United States)
7:30 pm - 7:55 pm	James Long (INTEGRIS Advanced Cardiac Care, United States) "How to Get the Most Out of Our Current Technology"
7:55 pm - 8:10 pm	Discussion
8:10 pm - 8:35 pm	Eduardo Rame (Thomas Jefferson University Hospital, United States) "Keeping the Paradigm [Mechanical Unloading] BUT Changing the Narrative : Myocardial ASSISTANCE to Long Term CF-DEVICE SUPPORT"
8:35 pm - 8:50 pm	Discussion
8:50 pm - 9:15 pm	Igor Gosev (University of Rochester Medical Center, United States) "Swipe Right and Go to Vegas: From Acute Shock to Durable LVAD"
9:15 pm - 9:30 pm	Discussion
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

Stephane Garrigue

Research reported in this publication was supported by the National Heart, Lung, And Blood Institute of the National Institutes of Health under Award Number R13HL168929. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

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