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Atherosclerosis

Gordon Research Conference

June 15 - 20, 1997
Chairs Helen H. Hobbs and David P. Hajjar
Vice Chair

Conference Program

Sunday, June 15

7:00 - 9:30 PM: CELL SIGNALING EVENTS AFFECTING VASCULAR TONE AND GROWTH

Session Leader: Masashi Yanagisawa
  • Masashi Yanagisawa - The Role of Endothelins and Receptors in Vascular Homeostasis: Genetic Analysis in Mice
  • Jonathan Stamler - Hemoglobin: A Microcosm of NO signaling in the Vasculature
  • Thomas Sato - Roles of TIE Receptor Tyrosine Kinases in Blood Vessel Formation

Monday, June 16

9:00 - 12:30PM: GENETIC APPROACHES TO THE STUDY OF ATHEROSCLEROSIS

Session Leader: Eric Lander
  • Jan Breslow - Genetic Modifiers of Atherosclerosis in the ApoE Knockout Mouse
  • Rick Lifton - Molecular Genetics of Hypertension and its Consequences
  • Jonathan Cohen - Genetic Determinants of Plasma HDL-Cholesterol Levels

4:30 - 5:30PM: Workshop:

SCIENTIFIC OPPORTUNITIES IN CARDIOVASCULAR RESEARCH

Jan Breslow

7:30 - 10:00PM: EXPERIMENTAL MODELS AND METHODOLOGIES TO STUDY ATHEROSCLEROTIC LESIONS AND PLAQUE RUPTURE

Session Leader: Russell Ross
  • Russell Ross -Studies of Chimeric ApoE-/- Mice
  • Jake Lusis - Mouse Models: Secretory Phospholipase A2, Lipid Oxidation, and Atherosclerosis
  • Arthur Beaudet - Genetic Analysis of Leukocyte and Endothelial Cell Adhesion Molecules in Atherosclerosis
  • Andras Nagy - ES Cell-Mediated Genetic Approaches for Studying Vessel Development
  • David Stern - Accelerated Atherosclerosis and Diabetes: Role of RAGE

Tuesday, June 17

9:00 - 12:30PM: USE OF GENE TRANSFER TECHNIQUES IN ANGIOGENESIS AND ATHEROGENESIS

Session Leader: Jeff Leiden
  • Jeff Leiden - Adenovirus-Mediated Gene Transfer to Understand and Treat Vascular Proliferative Disorders
  • Elizabeth Nabel - Cyclin-Dependent Kinase Inhibitors and Vascular Disease
  • Jeffrey Isner - VEGF Gene Transfer Offers Clues to Endogenous Mechanisms
  • Victor Dzau - E2F Transcriptional Factor Decoy for Genetic Engineering of Vascular Graft

4:30-5:30PM: Workshop

CLINICAL APPROACH TO CORONARY ARTERY DISEASE: BENCH TO BEDSIDE

Victor Dzau, Elizabeth Nabel, Jeff Leiden, Antonio Gotto

4:30-6:30: Poster Session 1

7:30 - 10:00PM: ROLE OF INFLAMMATORY CELLS IN LESION PROGRESSION AND REGRESSION

Session Leader: Edgar Haber
  • Edgar Haber - Role of MHC I and MHC II in Transplant Arteriosclerosis
  • Peter Libby - CD40L: Not Just Another Cytokine
  • Joe Witztum - Humoral Response to Oxidation-Dependent Epitopes and Potential Roles in Atherosclerosis
  • Goran Hansson - Cell-Mediated Immunity and the Regulation of Inflammation

Wednesday, June 18

9:00 - 12:30PM: LIPOPROTEIN BIOLOGY AND ATHEROSCLEROSIS

Session Leader: Helen Hobbs
  • Ira Tabas - Sphingomyelinase and Atherogenesis
  • Jay Heinecke - Pathways for Oxidative Damage in Atherosclerosis
  • Nobuyo Maeda - Human Apolipoprotein E Alleles in Mice and Atherosclerosis
  • *MacRae Linton - Macrophage Apolipoprotein E in Atherosclerosis
  • *Maria Febbraio - The Role of CD36 in Atherosclerotic Foam Cell Development
  • *Attilio Rigotti - Recent Studies of SR-BI function in vivo

4:30-5:30PM: Workshop

ANALYSIS OF LESIONS IN MAN AND MOUSE

Alan Daugherty, Sotirios Tsimikas, MacRae Linton

7:30 - 10:00 PM: MATRIX AND VASCULAR REMODELING

Session Leader: Richard Hynes
  • Richard Hynes - Integrins in Vascular Form and Function
  • Jack Lawler - Thrombospondins in the Vessel Wall
  • Denisa Wagner - Leukocyte Adhesion Receptors in Atherosclerosis and Obesity
  • Bjorn Olsen - Venous Malformations - Genetics Abnormalities in Vascular Morphogenesis

Thursday, June 19

9:00 - 12:30PM: MOLECULAR LINKS BETWEEN THROMBOSIS AND ATHEROSCLEROSIS

Session Leader: David Loskutoff
  • David Loskutoff - Introduction and Discussion of Murine Models of Thrombotic Disease
  • Dan Lawrence - A Molecular Switch Regulating Smooth Muscle Cell Migration by a Single Conformational Change
  • Peter Carmeliet - Role of Urokinase in Activation of Matrix Metalloproteinase During Aneurysm Formation in Atherosclerotic Mice
  • Jay Degen - Role of Plasminogen and Fibrinogen in Atherosclerosis
  • Fahumiya Samad - Adipose Tissue Expression of Hemostatic Genes: Potential Contributor to Cardiovascular Complications in Obesity?

4:30-6:30: Poster Session 2

8:00-9:00 PM: KEY NOTE SPEECH

Session Leader: David Hajjar
  • Oliver Smithies - Gene Targeting in the Study of Genetic Diseases

Conference Links

Conference History
Additional Fee Info

Atherosclerosis (GRS)
June 21 - 22, 2025
Biomechanics in Vascular Biology and Disease
August 3 - 8, 2025
Endothelial Cell Phenotypes in Health and Disease
June 30 - July 5, 2024
Molecular and Cellular Biology of Lipids
July 27 - August 1, 2025
Vascular Cell Biology
January 12 - 17, 2025


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