| Session 1 |
Sunday PM |
| Insights into receptors and cholesterol trafficking |
|
Michael Phillips, Discussion leader |
| 7:30-8:00 |
Michael Phillips
Mechanisms of cholesterol flux between HDL and cells |
| 8:00-8:30 |
Jack Oram
Apolipoprotein-mediated removal of cellular cholesterol and phospholipid |
| 8:30-8:45 |
Break |
| 8:45-9:15 |
Fred de Beer
SRB1 is a specific apolipoprotein A1 receptor |
| 9:15-9:45 |
Scott Argraves
Cubilin, a receptor that mediates HDL endocytosis and lysosomal degradation |
| Session 2 |
Monday AM |
| Experimental models of atherosclerosis |
|
Jake Lusis, Discussion leader |
| 9:00-9:30 |
Tom Innerarity
Engineering a non-atherogenic LDL: Evidence for the response-to-retention hypothesis |
| 9:30-10:00 |
Nobuyo Maeda
Interaction of genetic factors in the development of atherosclerosis |
| 10:00-10:30 |
Israel Charo
The role of monocytes in atheroma formation: Insights from the MCP-1 and CCR2 knock-out mice |
| 10:30-11:00 |
Coffee Break |
| 11:00-11:30 |
Renee LeBoeuf/Sandy Schreyer
Molecular mechanisms contributing to insulin resistance and obesity in mice |
| 11:30-12:00 |
Clay Semenkovich
Peroxisome proliferator-activated receptor alpha and atherosclerosis |
| Session 3 |
Monday PM |
| Gene regulation in hypoxia and ischemia |
|
Lorenz Poellinger, Discussion leader |
| 7:30-8:00 |
Lorenz Poellinger
Signal transduction in hypoxic cells |
| 8:00-8:30 |
Eli Keshet
Oxygen-regulated formation and regression of blood vessels |
| 8:30-8:45 |
Break |
| 8:45-9:15 |
Greg Semenza
Cardiovascular responses to hypoxia/ischemia mediated by hypoxia-inducible factor 1 |
| 9:15-9:45 |
Peter Carmeliet
Genetic models of ischemia in cardiovascular disease |
| Session 4 |
Tuesday AM |
| Oxidation and inflammation in vascular disease |
|
Jay Heinecke, Discussion leader |
| 9:00-9:30 |
Jay Heinecke
Pathways of LDL oxidation in the artery wall |
| 9:30-10:00 |
Garret FitzGerald
Isoprostanes: Indices of oxidant stress in vivo |
| 10:00-10:30 |
Balz Frei
Antioxidants and lipid peroxidation in plasma and in vivo |
| 10:30-11:00 |
Coffee Break |
| 11:00-11:30 |
John Baynes
Lipid peroxidation in atherosclerosis, diabetes and uremia: Biomarkers and inhibitors |
| 11:30-12:00 |
Roland Stocker
Aortic lipid peroxidation and atherosclerosis in animal models |
| Session 5 |
Tuesday PM |
| Genetics of atherosclerosis |
|
Helen Hobbs, Discussion leader |
| 7:30-7:35 |
Helen Hobbs
Introduction |
| 7:35-8:05 |
Aravinda Chakravarti
The nature of genetic variation underlying complex traits |
| 8:05-8:35 |
Eric Boerwinkle
Genetics of hypertension: the morning after |
| 8:35-8:50 |
Break |
| 8:50-9:20 |
Jake Lusis
Characterization of a novel gene that causes combined hyperlipidemia in mice |
| 9:20-9:50 |
James Scott
Molecular genetics of the metabolic overlap syndrome |
| 9:50-10:00 |
Helen Hobbs
Finale |
| Session 6 |
Wednesday AM |
| Atherogenic and modified lipoproteins |
|
Ira Tabas, Discussion leader |
| 9:00-9:30 |
Ira Tabas
Secretory sphingomyelinase, lipoprotein aggregation and atherogenesis |
| 9:30-10:00 |
Petri Kovanen
Molecular aspects of lipoprotein modification |
| 10:00-10:30 |
Diane Tribble
Enhanced retention and degradation of lipoproteins in the aorta of irradiated mice: A model of oxidant-induced atherosclerosis |
| 10:30-11:00 |
Coffee Break |
| 11:00-11:30 |
Tucker Collins
"Role of NF-kB in atherosclerosis and inflammation." |
| 11:30-12:00 |
David Hajjar/Maria Febbraio
Molecular and cellular insights into CD36: A scavenger receptor involved in cholesterol trafficking |
| Special Session |
Wednesday PM |
| After dinner speaker |
| 7:30-9:00 |
Louis Ignarro - 1998 Nobel Laureate
Nitric oxide in vascular biology and medicine
|
| Session 7 |
Thursday AM |
| Microorganisms and immunity in atherogenesis |
|
Goran Hansson, Discussion leader |
| 9:00-9:30 |
Goran Hansson
Protective immunity in atherosclerosis |
| 9:30-10:00 |
Francis Bayard
Hormonal regulation of atheroprotective immunity |
| 10:00-10:30 |
Steve Epstein
Role of cytomegalovirus in atherosclerosis and coronary disease |
| 10:30-11:00 |
Coffee Break |
| 11:00-11:30 |
Mike Rosenfeld
Chlamydia pneumonia and atherosclerosis: Insights from animal models |
| 11:30-12:00 |
Kurt Bachmaier
Chlamydia and inflammatory heart disease |
| 12:00-12:30 |
Georg Wick
Heat shock proteins, microorganisms and atherosclerosis |
| Session 8 |
Thursday PM |
| Plaque progression and rupture |
|
Peter Libby, Discussion leader |
| 7:30-8:00 |
Erling Falk
Pathology of plaque rupture |
| 8:00-8:30 |
Peter Libby
Molecular mechanisms of plaque rupture |
| 8:30-8:45 |
Break |
| 8:45-9:15 |
Allison Schecter
Tissue factor expression by vascular cells |
| 9:15-9:25 |
Shu Ye
Metalloproteinase gene polymorphism |
| 9:25-9:35 |
Giuseppina Caligiuri
Myocardial infarction in apoE-KO mice |
| 9:35-9:45 |
Jorge Plutzky
PPAR-gamma mediated gene regulation in the plaque |
