| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| 5:00 pm | Chairs and Discussion Leaders meeting |
| 6:00 pm | Dinner |
| 7:15 pm | Welcoming comments |
| 7:30 pm - 9:30 pm | Immune Function |
| Discussion Leader: Goran K. Hansson, M.D., Ph.D. (Karolinska Institute) |
| 7:30 pm - 7:50 pm | Goran K. Hansson, M.D., Ph.D. (Karolinska Institute)
Role of memory, help, and restriction in proatherogenic and atheroprotective immunity |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Ziad Mallat, Ph.D. (INSERM)
The role of regulatory T cells in atherosclerosis |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Joseph L. Witztum, M.D. (UC, San Diego)
Novel aspects of innate immunity in atherosclerosis |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:10 pm | Amy S. Major, Ph.D. (Vanderbilt University)
The role of natural killer T lymphocytes in atherosclerosis |
| 9:10 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:25 pm | Stewart C. Whitman, Ph.D. (Ottawa Heart Institute)
Proatherogenic role of the IL-12, IL-18 and interferon-gamma signaling cascade: lessons learned by using specific gene-targeted mouse models |
| 9:25 pm - 9:30 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Group Photo |
| 9:00 am - 12:30 pm | Inflammatory processes |
| Discussion Leader: Peter Libby, M.D. (Brigham and Women's) |
| 9:00 am - 9:20 am | Peter Libby, M.D. (Brigham and Women's)
Inflammation regulates plaque complication |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Moshe Arditi, M.D. (Cedar Sinai Medical Center)
Toll-like receptor signaling and atherosclerosis |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:20 am | Rama Natarajan, Ph.D. (City of Hope)
Diabetes and vascular inflammation |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am - 11:00 am | Coffee Break |
| 11:00 am - 11:20 am | Mark B. Pepys, M.D., Ph.D., F.R.S. (Royal Free & University College Medical School)
C-reactive protein: epiphenomenon or therapeutic target? |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Garret A. Fitzgerald, M.D. (University of Pennsylvania)
Eicosanoids and vascular biology |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:10 pm | Daniel I. Simon, M.D. (Brigham and Women's)
Inflammation and thrombosis |
| 12:10 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:25 pm | Jeanine D'Armiento, M.D., Ph.D. (Columbia University)
MMPs and aneurysms |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Viewing |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Thrombotic and hemostatic mechanisms |
| Discussion Leader: Shaun R. Coughlin, M.D., Ph.D. (UC, San Francisco) |
| 7:30 pm - 8:00 pm | Shaun R. Coughlin, M.D., Ph.D. (UCSF) |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | Mark B. Taubman, M.D. (University of Rochester)
Circulating forms of tissue factor as mediators of thrombosis and the response to arterial injury |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Bruce Furie, M.D. (Harvard Medical School)
Birth of a thrombus: In vivo visualization of thrombus formation |
| 9:20 pm - 9:30 pm | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Lipoprotein Metabolism |
| Discussion Leader: Mary G. Sorci-Thomas, Ph.D. (Wake Forest University) |
| 9:00 am - 9:20 am | Miranda van Eck, Ph.D. (Leiden University)
Role of SRB-I and ATP-binding cassette transporter A1 in atherogenesis |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Daniel J. Rader, M.D. (University of Pennsylvania)
Molecular regulation of HDL metabolism and reverse cholesterol ester transport in vivo |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:20 am | Alan M. Fogelman, M.D. (UC, Los Angeles)
Using apolipoprotein mimetics as a strategy to control inflammation |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am - 11:00 am | Coffee Break |
| 11:00 am - 11:20 am | Gwendalyn Randolph, Ph.D. (Mt. Sinai School of Medicine)
Altered emigration of dendritic cells in atherosclerosis |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Michael J. Thomas, Ph.D. (Wake Forest University School of Medicine)
Chemical cross-linking and mass spectrometry as a tool to elucidate the lipid-bound structure of HDL ApoA-I |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:10 pm | Vasanthy Narayanaswami, Ph.D. (Children's Hospital Oakland Research Center)
Lipid-bound conformation of apolipoprotein E4 |
| 12:10 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:25 pm | Jianjun Wang, Ph.D. (Wayne State)
The conformational changes of human apolipoprotein AI during HDL assembly |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Judging of Posters |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Metabolic Syndrome |
| Discussion Leader: Douglas Vaughan, M.D. (Vanderbilt University) |
| 7:30 pm - 8:00 pm | Anthony W. Ferrante, M.D., Ph.D. (Columbia University)
Macrophages in obesity and insulin resistance |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:30 pm | Peter Tontonoz, M.D., Ph.D. (UC, Los Angeles)
Nuclear receptors at the crossroads of lipid metabolism and inflammation |
| 8:30 pm - 8:40 pm | Discussion |
| 8:40 pm - 9:20 pm | Douglas Vaughan, M.D. (Vanderbilt University)
Proteomic insights into the vascular consequences of obesity |
| 9:20 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Macrophage Biology |
| Discussion Leader: Martha K. Cathcart, Ph.D. (Cleveland Clinic) |
| 9:00 am - 9:20 am | Martha K. Cathcart, Ph.D. (Cleveland Clinic)
Phospholipase regulation of monocyte chemotaxis |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Christopher K. Glass, M.D., Ph.D. (UC, San Diego)
Nuclear factors in macrophage activation |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:20 am | Catherine C. Hedrick, Ph.D. (University of Virginia)
Regulation of monocyte-endothelial interactions in diabetes |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am - 11:00 am | Coffee Break |
| 11:00 am - 11:20 am | Elaine Raines, M.S. (University of Washington)
Macrophage MMP-9 and plaque stability |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | William A. Muller, M.D., Ph.D. (Weill Medical College of Cornell University)
Molecular regulation of transendothelial migration |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:10 pm | Ara Aslanian, Ph.D. (Gladstone Institutes)
Role of PSOX in atherosclerosis |
| 12:10 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:25 pm | Janusz H.S. Kabarowski, Ph.D. (University of Alabama)
Lysophophatidylcholine action in atherosclerosis: role of the G2A receptor |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Judging of Posters |
| 6:00 pm | Dinner |
| 7:15 pm | Business Meeting |
| 7:30 pm - 9:30 pm | Vascular Wall Stem Cell Biology |
| Discussion Leader: Elizabeth G. Nabel, M.D. (National Institutes of Health) |
| 7:30 pm - 7:50 pm | Victor J. Dzau, M.D. (Duke University)
Paracrine hypothesis of stem cell action in cardiovascular repair |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Shahin Rafii, M.D. (Cornell University)
Contribution of hemangiogenic cells to dysregulated neo-vascularization |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Kenneth R. Chien, M.D., Ph.D. (Harvard University)
The Islet-1 heart progenitor story: Redefining cardiovascular physiology and disease in specific cell lineages |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Mark T. Keating, M.D. (Children's Hospital Boston)
Cardiac regeneration in zebrafish |
| 9:20 pm - 9:30 pm | Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Cell Biology of Atherosclerosis |
| Discussion Leader: Joseph Loscalzo, M.D., Ph.D. (Boston University) |
| 9:00 am - 9:20 am | Bradford C. Berk, M.D., Ph.D. (University of Rochester)
Flow-mediated atheroprotection: Redox signaling mechanisms |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Cecilia M. Giachelli, Ph.D. (University of Washington)
Cellular control of vascular calicification |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:20 am | John P Cooke, M.D., Ph.D. (Stanford University)
"Role of endogenous NOS inhibitors in vascular disease" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am - 11:00 am | Coffee Break |
| 11:00 am - 11:20 am | Joseph Loscalzo, M.D., Ph.D. (Boston University)
Endothelial oxidant stress and thiol proteome |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Roy Silverstein, M.D. (Cleveland Clinic Foundation)
CD36 signaling cascades in foam cell formation |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:10 pm | William A. Frazier, Ph.D. (Washington University)
Characterization of the anti-OxLDL autoantibody responses in CD47/apoE and CD36/apoE double null mice and its relationship to atherosclerosis |
| 12:10 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:25 pm | Dennis C. Bruemmer, M.D. (University of Kentucky)
Regulation of vascular smooth muscle cell function by nuclear receptor |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Viewing |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Human and Animal Genetics of Atherosclerosis |
| Discussion Leader: Aldons J. Lusis, Ph.D. (UC, Los Angeles) |
| 7:30 pm - 7:50 pm | Paivi Pajukanta, M.D., Ph.D. (UC, Los Angeles)
Genetics of familial combined hyperlipdemia |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Alan D. Attie, Ph.D. (University of Wisconsin)
Mining for type 2 diabetes genes using mouse genetics |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Carol C. Shoulders, Ph.D. (Imperial College)
Genetic insights into intracellular lipid transport and familial combined hyperlipidemia |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Jonathan D. Smith, Ph.D. (Cleveland Clinic)
QTL and gene arrays in atherosclerosis susceptibility |
| 9:20 pm - 9:30 pm | Discussion |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |
