SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
5:00 pm | Meeting of Chairs and Discussion Leaders |
6:00 pm | Dinner |
7:30 pm - 7:45 pm | Welcome / Introductory Comments by GRC Site Staff & Chairs |
7:45 pm - 9:30 pm | Macrophage Heterogeneity |
| Discussion Leader: Siamon Gordon (University of Oxford) |
7:45 pm - 8:05 pm | Frédéric Geissmann (Université René Descartes Paris V)
"Monocyte subsets and the immune response" |
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:35 pm | Filip Swirski (Massachusetts General Hospital)
"Behavior of reservoir monocytes in inflammation" |
8:35 pm - 8:45 pm | Discussion |
8:45 pm - 9:05 pm | Siamon Gordon (University of Oxford)
"Heterogeneity of macrophage functions: Receptors and responses" |
9:05 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Short Talk: Koka Motoyama (University of Washington)
"Hypercholesterolemia induces a unique subset of macrophage foam cells in ApoE -/- mice" |
9:25 pm - 9:30 pm | Discussion |
9:30 pm | Reception |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Genomics and Genetics of Atherosclerosis |
| Discussion Leader: Ruth McPherson (University of Ottawa Heart Institute) |
9:00 am - 9:20 am | Karen Mohlke (University of North Carolina, Chapel Hill)
"Common genetic variants for lipids and other metabolic risk factors for cardiovascular disease" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Sekar Kathiresan (Massachusetts General Hospital)
"Genetic basis for complex cardiovascular traits" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:20 am | Robert Hegele (Robarts Research Institute)
"Rare genomic variants and atherosclerosis" |
10:20 am - 10:30 am | Discussion |
10:30 am | Coffee Break / Group Photo |
11:00 am - 11:20 am | Bev Paigen (Jackson Laboratory)
"Health status of animal room affects atherosclerosis and mapping of genetic loci for atherosclerosis susceptibility in mice" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Ruth McPherson (University of Ottawa Heart Institute)
"Functional analysis of CHD genetic variants" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Short Talk: Vladimir Reiser (Merck Research Laboratories)
"REPLICA Biobank - an archive of human atherosclerotic plaque samples for identification of genetic, molecular and imaging biomarkers associated with cardiovascular risks and plaque composition" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Short Talk: Nehal Mehta (University of Pennsylvania)
"A novel GWAS atherosclerosis locus regulates plasma levels of CXCL12" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Stem Cells and Lineage Acquisition |
| Discussion Leader: Qingbo Xu (King's College London) |
7:30 pm - 7:50 pm | Qingbo Xu (King's College London)
"Stem cells in the pathogenesis of atherosclerosis" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Yi Zhu (Peking University)
"AMPK in endothelial progenitor cell differentiation" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Ann Canfield (University of Manchester)
"Perivascular stem cells" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Short Talk: Isabel Casimiro (Albert Einstein College of Medicine)
"Impaired macrophage function in mice lacking allograft inflammatory factor-1 (AIF-1)" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Short Talk: Gareth Hyde (University of Manchester)
"The regulation of VSMC adipogenic differentiation by Axl tyrosine kinase" |
9:25 pm - 9:30 pm | Discussion |
9:30 pm | Reception |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Calcific vasculopathy and valvulopathy |
| Discussion Leader: Dwight Towler (Washington University) |
9:00 am - 9:20 am | Elena Aikawa (Massachusetts General Hospital)
"Molecular imaging of pro-inflammatory mechanisms of cardiovascular calcification" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Robert Terkeltaub (University of California-San Diego)
"Ectoenzyme regulation of arterial calcification" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:20 am | Nalini Rajamannan (Northwestern University)
"The clinical spectrum of calcific aortic stenosis: Mediators and modifiers" |
10:20 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:20 am | Jordan Miller (University of Iowa)
"Oxidative stress & osteogenic signaling in valvular and vascular calcification" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Catherine Shanahan (King's College London)
"Microparticles and nanoparticles in vascular calcification" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Short Talk: Wilhelm Jahnen-Dechent (RWTH Aachen University)
"Fetuin-A protects against atherosclerotic calcification in chronic kidney disease" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Short Talk: Cindy Yip (University of Toronto)
"C-type natriuretic peptide protects valvular interstitial cells against pathological differentiation and calcification" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Future therapeutics and diagnostics: Nanotechnology and Atherosclerosis |
| Discussion Leader: Sam Wickline (Washington University) |
7:30 pm - 7:50 pm | Jeff Bulte (Johns Hopkins)
"Nanoparticles for cellular labeling and therapeutics" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Sam Wickline (Washington University)
"Targeted theranostic nanoparticles for multiple clinical applications" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Denis Buxton (National Institutes of Health)
"Nanobiology of atherosclerosis" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Short Talk: Oscar Puig (Merck Research Laboratories)
"Identification of biomarkers of plaque status: Gene expression profiling of human atherosclerosis plaque" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Short Talk: Bo Jansson (Bioinvent International)
"Oxidation-specific epitopes on LDL used as biomarkers for vulnerable plaques in atherosclerosis" |
9:25 pm - 9:30 pm | Discussion |
9:30 pm | Reception |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Lipids, Lipoproteins and Dysmetabolic Conditions |
| Discussion Leader: Stan Hazen (Cleveland Clinic) |
9:00 am - 9:20 am | Kerry-Anne Rye (University of Sydney)
"High Density Lipoproteins increase the insulin secretory capacity of pancreatic beta cells" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Jonathan Smith (Cleveland Clinic)
"Inflammation impairs reverse cholesterol transport" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:20 am | Clay Semenkovich (Washington University)
"Novel approaches to insulin resistance and vascular disease" |
10:20 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:20 am | Theo Van Berkel (Leiden University)
"Macrophage cholesterol transporters and atherogenesis" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Lisa Cassis (University of Kentucky)
"Effects of the low calorie sweetener, D-tagatose, vs sucrose on serum lipids in atherosclerotic mice and diabetic humans" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Short Talk: Longhue Fang (UCSD)
"Live imaging of oxidized lipoproteins in the vasculature of hypercholesterolemic zebrafish" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Short Talk: Muredach Reilly (University of Pennsylvania)
"Adipocyte modulation of high-density lipoprotein cholesterol" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | Plaque Dynamics |
| Discussion Leader: Richard Lee (Brigham and Women's Hospital) |
7:30 pm - 7:50 pm | Hanjoong Jo (Emory)
"Bone morphogenetic proteins and shear stress" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Guillermo Garcia-Cardena (Brigham and Women's Hospital)
"Transcriptional regulation by Klf2/4" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Craig Simmons (University of Toronto)
"Biomechanical stimuli and cardiac valve pathobiology" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Short Talk: Mete Civelek (University of Pennsylvania)
"Chronic endoplasmic reticulum stress in athero-susceptible arterial endothelium in vivo" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Short Talk: Lisa Tannock (University of Kentucky)
"Serum amyloid A accelerates atherosclerosis development" |
9:25 pm - 9:30 pm | Discussion |
9:30 pm | Reception |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Atherosclerosis Progression and Regression |
| Discussion Leaders: Elaine Raines (University of Washington) and Ed Fisher (New York University) |
9:00 am - 9:20 am | Ira Tabas (Columbia University)
"Mechanisms and consequences of efferocytosis in the progression of atherosclerosis" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | J.W. Tervaert (Cardiovascular Research Institute Maastricht)
"Acceleration of atherosclerosis and autoimmunity" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:20 am | Guo-Ping Shi (Brigham and Women's Hospital)
"Mast cell functions in cardiovascular diseases" |
10:20 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:20 am | Elaine Raines (University of Washington)
"Do proteases really break atherosclerotic plaques?" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Ed Fisher (New York University)
"HDL and regression: regulation of macrophage migration and inflammatory state" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Collin Stultz (Massachusetts Institute of Technology)
"New insights into the mechanism of collagenolysis" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Systems Biology of Atherosclerosis: "The Artery Wall and Beyond" |
| Discussion Leaders: Martha Cathcart (Cleveland Clinic) and Linda Demer (UCLA) |
7:30 pm - 7:40 pm | Brian Bennett (UCLA)
"Novel aystems genetic approach for identification of atherosclerotic susceptibly loci atherosclerotic susceptibly loci" |
7:40 pm - 7:45 pm | Discussion |
7:45 pm - 8:05 pm | Elizabeth Gold (Systems Biology Institute)
"Systems approach to understanding macrophage differentiation" |
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:35 pm | Rita Upmacis (Weill Cornell Medical College)
"Nitrative and oxidative stress: thinking outside the plaque" |
8:35 pm - 8:45 pm | Discussion |
8:45 pm - 9:20 pm | Lecture in Honor of the Journal of Lipid Research 50th Anniversary: Stan Hazen (Cleveland Clinic)
"Metabolomics studies implicate choline metabolism in cardiovascular disease pathogenesis" |
9:20 pm - 9:30 pm | Discussion |
9:30 pm | Reception |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |