SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Endothelial and Smooth Muscle Cell Dysfunction in Vascular Disease Pathogenesis |
| Discussion Leaders: William Sessa (Yale Univ. School of Med.) and Elaine Raines (Univ. of Washington) |
7:40 pm - 8:00 pm | William Sessa (Yale Univ. School of Med.)
"Novel Mechanisms Controlling Vascular Function" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:30 pm | George King (Harvard Medical School) "Loss of Endothelial Cell Insulin Signaling and Atherosclerosis" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:00 pm | Martin Bennett (Addenbrooke's Centre for Clinical Investigation)
"Smooth Muscle Cell Apoptosis" |
9:00 pm - 9:10 pm | Discussion |
9:10 pm - 9:20 pm | Olga Stenina (Cleveland Clinic)
"Thrombospondin 4 and Atherosclerosis" |
9:20 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Macrophage Biology in Atherosclerosis |
| Discussion Leaders: Edward Fisher (NYU School of Medicine) and David Greaves (Sir William Dunn School of Pathology) |
9:00 am - 9:20 am | David Greaves (Sir William Dunn School of Pathology)
"Novel Regulation of Macrophage Inflammation" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Ajay Chawla (Stanford Univ. School of Medicine)
"Diabetes, Nuclear Receptors, and M1/M2 Macrophages" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:30 am | Group Photo / Coffee Break |
10:30 am - 11:50 am | Israel Charo (Gladstone Institute of Cardiovascular Disease)
"Chemokines and Atherosclerosis" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Gwendalyn Randolph (Mt. Sinai School of Medicine)
"Macrophage Heterogeneity and Trafficking in Atherosclerosis" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Catherine (Lynn) Hedrick (La Jolla Inst. for Allergy and Immunology)
"Nuclear Receptors in Innate Immunity" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Esther Lutgens (Maastricht University Medical Center)
"CD40-CD40L in Atherosclerosis" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Lazar Bojic (Univ. of Western Ontario)
"Inhibition of VLDL-induced macrophage inflammation by activation of PPAR delta" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Adaptive Immunity in Atherosclerosis |
| Discussion Leader: Goran Hansson (Karolinska Institute) |
7:30 pm - 7:50 pm | Andrew Lichtman (Brigham and Womens Hospital)
"T Cells and Atherosclerosis" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Goran Hansson (Karolinska Institute)
"Antigen Specificity in Cell Immune Responses in Atherosclerosis" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Klaus Ley (La Jolla Inst. for Allergy and Immunology)
"Trafficking of Adaptive Immune Cells in Atherosclerosis" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Giuseppina Caligiuri (INSERM)
"Pecam, T cells, and Atherosclerosis" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Mansori Aikawa (Brigham and Women's Hosp.)
"Dll4-Notch Signaling Promotes Macrophage Activation and Cardiometabolic Disorders" |
9:25 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Clinical Perspectives, Biomarkers, and the Vulnerable Patient |
| Discussion Leaders: Stan Hazen (Cleveland Clinic) and Peter Libby (Harvard Medical School) |
9:00 am - 9:20 am | Thomas Wang (Mass. General Hospital)
"Lessons from the Framingham Heart Study" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Frank Sacks (Harvard School of Public Health)
"Apolipoprotein C-III, Atherosclerosis, and Coronary Heart Disease" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:10 am | Stephan Baldus (University Hospital Hamburg)
"Myeloperoxidase and Coronary Artery Disease" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:40 am | Coffee Break |
10:40 am - 11:00 am | Peter Libby (Harvard Medical School)
"Molecular Imaging to Detect the Vulnerable Patient" |
11:00 am - 11:10 am | Discussion |
11:10 am - 11:30 am | Karine Clement (INSERM)
"Obesity, Coronary and Cardiac Diseases: Implications of Adipose Inflammation and Tissue Remodeling" |
11:30 pm - 11:40 am | Discussion |
11:40 am - 12:00 pm | Clay Semenkovich (Washington Univ. School of Medicine)
"Novel Therapies for Metabolic Syndrome" |
12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:20 pm | Steven Rosenberg (CardioDx)
"Development, Clinical Validation, and Initial Outcomes with a Gene Expression Test for Obstructive Coronary Artery Disease" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Innate Immunity and Inflammation in Atherosclerosis |
| Discussion Leader: Kathryn Moore (NYU Medical Center) |
7:30 pm - 7:50 pm | Michael Fessler (National Institute of Environmental Health Sciences)
"Inflammation Cross Talk with Reverse Cholesterol Transport" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Antonio Castrillo (Instituto Investigaciones Biomedicas ‘Alberto Sols’ Consejo Superior)
"Apoptotic Cell Clearance and LXRs" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Filip Swirski (Mass. General Hospital)
"Spleen Monocyte Reservoir and Atherosclerosis" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Frederick Sheedy (NY University School of Medicine)
"CD36: The Toll-Gate for Inflammasome Activation in Atherosclerosis" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Mireille Ouimet (Ottawa Heart Institute)
"Autophagy Regulates Cholesterol Efflux in Macrophage Foam Cells" |
9:25 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | HDL Function and Plaque Regression |
| Discussion Leaders: John Chapman (INSERM) and Alan Tall (Columbia Univ.) |
9:00 am - 9:20 am | Dan Rader (Univ. of Pennsylvania)
"HDL/TG Genes and Reverse Cholesterol Transport" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Edward Fisher (NYU School of Medicine)
"Regression of Atherosclerosis" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:10 am | Ryan Temel (Wake Forest University School of Medicine)
"Non-Biliary Reverse Cholesterol Transport" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:40 am | Coffee Break |
10:40 am - 11:00 am | Alan Tall (Columbia Univ.)
"Cholesterol Efflux Pathways and Myeloid Cell Proliferation" |
11:00 am - 11:10 am | Discussion |
11:10 am - 11:30 am | Mary Sorci-Thomas (Wake Forest University School of Medicine)
"HDL and Immune Functions" |
11:30 pm - 11:40 am | Discussion |
11:40 am - 12:00 pm | Stan Hazen (Cleveland Clinic)
"Novel HDL Functions" |
12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:20 pm | Christian Besler (University Hospital Zurich)
"Endothelial-Protective Effects of HDL that are Impaired in Patients with Coronary Disease" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
7:30 pm - 9:30 pm | Genetics and Genomics I, and Keynote Address |
| Discussion Leaders: Jonathan Smith (Cleveland Clinic) and Daniel Teupser (University Hospital Leipzig) |
7:30 pm - 7:50 pm | Daniel Teupser (University Hospital Leipzig)
"QTL Mapping of the Plasma Proteome (pQTL)" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Arya Mani (Yale School of Medicine)
"Coronary Artery Disease: Identifying a Disease Gene and Understanding its Function" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:40 pm | Ralph Burkhardt (University of Leipzig)
"TRIB1" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Keynote Lecture: Sek Kathiresan (Mass. General Hospital)
"Exome Sequencing, Rare Variants, and Risk for Early-Onset Myocardial Infarction" |
9:20 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Genetics and Genomics II |
| Discussion Leaders: Sek Kathiresan (Mass. General Hospital) and Dan Rader (Univ. of Pennsylvania) |
9:00 am - 9:20 am | Axel Visel (Lawrence Berkeley National Laboratory) "9p21 Locus and Enhancers in the Heart" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:45 am | Lesca Holdt (University Hospital Leipzig) "9p21 Locus Studies in Humans" |
9:45 am - 9:55 am | Discussion |
9:55 am - 10:10 am | J. Brian Kim (UCLA)
"The effect of 9p21 risk locus neighboring genes on atherosclerosis in mice" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:40 am | Coffee Break |
10:40 am - 11:00 am | Chris O'Donnell (NHLBI Framingham Heart Study)
"Framingham in the Genomic Era" |
11:00 am - 11:10 am | Discussion |
11:10 am - 11:30 am | Danish Saleheen (University of Cambridge) "Emerging biological pathways and CHD risk - use of genetic and biomarker studies to assess causal relevance"
|
11:30 pm - 11:40 am | Discussion |
11:40 am - 11:50 am | Nehal Mehta (Univ. of Pennsylvania) "Chr10q11 Atherosclerosis Locus Modulation of Plasma and Adipose CXCL12 to in vivo Inflammation" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Kiran Musunuru (Mass. General Hospital) "SORT1"
|
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 6:00 pm | Free Time |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | New Directions in Therapeutics |
| Discussion Leader: Philip Barter (The Heart Research Institute, Sydney) |
7:30 pm - 7:50 pm | Kathryn Moore (NYU Medical Center)
"miR33 Antagonism" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Philip Barter (The Heart Research Institute, Sydney)
"CETP Inhibition as an Anti-Atherosclerosis Strategy" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Viktoria Gusarova (Regeneron Pharmaceuticals)
"PCSK9 inhibition therapy" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Tom Schall (ChemoCentryx)
"CXCR7 inhibition" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Zhaosha Li (Leiden)
"Niacin Reduces Hepatic and Plasma CETP Levels by Diminishing Liver Macrophage Content in CETP Transgenic Mice" |
9:25 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |