Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Atherosclerosis and Heart Disease: From Population Science to Molecular Mechanisms
7:40 pm - 8:05 pm
"Subclinical Arterial Disease Across the Lifespan"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
"Lipoprotein(a) and Cardiovascular Disease"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
"Targeting Inflammation in Atherosclerosis"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:20 am
"Multidimensional Inflammation in Vessels"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"The Gut-Liver Axis in Cardiovascular Disease"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
"Atherosclerotic Process Drives Arterial Damage, Abdominal Aortic Aneurysm Formation, and Rupture"
10:50 am - 11:00 am
Discussion
11:00 am - 11:20 am
"Dysregulation of Inflammation-Resolution in Atherosclerosis"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"HDL Removes More Than Cholesterol from Plaques: A Lipidomic Perspective"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
The Single Cell Resolution Revolution: From Single Cells to Cell Subsets
6:00 pm - 6:20 pm
"Myeloid Cells in Murine and Human Atherosclerosis: One Cell at a Time"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"Single-Cell Approaches Applied to Human Atherosclerosis"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"Prognostic Value of Single RNA Sequencing in Identifying Leukocyte Phenotypes Predicting CV Mortality"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Monocyte Heterogeneity Predicts Human Cardiovascular Risk"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
9:00 am - 9:25 am
"Multiplicative Effects of Common Risk Alleles"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Systems Genetics of Endothelial Cells for Vascular Disease"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
"Targeting Innate Immunity in Cardiovascular Disease"
11:05 am - 11:15 am
Discussion
11:15 am - 11:40 am
"CRISPRi-Perturb-Seq in Endothelial Cells Links Atherosclerosis Risk Loci to Novel KLF2/4 Regulatory Genes"
11:40 am - 11:55 am
Discussion
11:55 am - 12:20 pm
"Manipulating Bile Acid Production using Genome Editing to Modulate Cardio-Metabolic Disease"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Hematopoiesis and Reprogramming
6:00 pm - 6:20 pm
"Clonal Hematopoiesis and Atherosclerotic Cardiovascular Disease"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"High Salt Diet Promotes Atherosclerosis by Altering Hematopoiesis"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"Endogenous Ligands Reprogram Macrophages to Drive Hyperinflammation"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Endothelial ANGPTL4 in Metabolic Reprograming and Atherosclerosis"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
The Vasculature and the Heart
9:00 am - 9:20 am
"SMC Phenotypes and Functions in Vascular Disease"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
"Pathogenesis of Immune Checkpoint Inhibitor Myocarditis"
10:50 am - 11:00 am
Discussion
11:00 am - 11:15 am
"Stromal-Immune Crosstalk Underlying Post-Infarction Cardiac Repair"
11:15 am - 11:25 am
Discussion
11:25 am - 11:40 am
"Dissecting the Functions of APRIL in Cardiovascular Disease"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Tailored sHDL with Bioactive Antiatherosclerotic miRNAs"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Protease Activated Receptor 2 is Critical for Vascular Smooth Muscle Cell Transition to a Macrophage-Like State"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
6:00 pm - 6:20 pm
"Neutrophils in Cardiovascular Inflammation: From Physiology to Therapeutic Intervention"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"Heterogeneity of Tissue-Resident Macrophages"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"Defining the Functions and Repertoire of IgM Antibodies in Atherosclerosis"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Adaptive Response in Atherosclerosis"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Metabolism, Metabolites and Mitochondria
9:00 am - 9:20 am
"Reprogramming Macrophage Metabolism by Innate Immune Activation"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Crosstalk between Metabolism and Hematopoiesis in Atherosclerosis"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
"Lysosomal Nutrient Sensing in Macrophages: A Critical Nexus in the Pathophysiology of Atherosclerosis"
10:50 am - 11:00 am
Discussion
11:00 am - 11:20 am
"Mitochondrial Dynamics and Cardiometabolic Disease"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Lipophagy in Atherosclerosis"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Mitochondria as a Nexus of Lipid Metabolism and Signaling: Implications for Cardiometabolic Disease"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
6:00 pm - 6:20 pm
"Reprogramming the Epigenomic Landscape During Hematopoiesis"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"Cholesterol Efflux Pathways and Atherosclerosis"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"Life, Death and Zombies in the Atherosclerotic Plaque"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Krebs Cycle Reprogrammed for Immunity and Inflammation"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure