Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Atherosclerosis and Heart Disease: From Population Science to Molecular Mechanisms
Discussion Leader: Masanori Aikawa (Brigham and Women's Hospital and Harvard Medical School, United States)
7:40 pm - 8:05 pm
Valentin Fuster (Mount Sinai Hospital, United States)
"Subclinical Arterial Disease Across the Lifespan"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
Anne Tybjærg-Hansen (Rigshospitalet, Copenhagen University Hospital, Denmark)
"Lipoprotein(a) and Cardiovascular Disease"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
Peter Libby (Brigham and Women’s Hospital and Harvard Medical School, United States)
"Targeting Inflammation in Atherosclerosis"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Systems Crosstalk
Discussion Leader: José Gabriel Barcia Durán (NYU Langone Health, United States)
9:00 am - 9:20 am
Andres Hidalgo (Yale University, United States)
"Multidimensional Inflammation in Vessels"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Thomas Vallim (University of California, Los Angeles, United States)
"The Gut-Liver Axis in Cardiovascular Disease"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
Clinton Robbins (University Health Network, Canada)
"Atherosclerotic Process Drives Arterial Damage, Abdominal Aortic Aneurysm Formation, and Rupture"
10:50 am - 11:00 am
Discussion
11:00 am - 11:20 am
Gabrielle Fredman (Albany Medical College, United States)
"Dysregulation of Inflammation-Resolution in Atherosclerosis"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Edward Fisher (NYU Grossman School of Medicine, United States)
"HDL Removes More Than Cholesterol from Plaques: A Lipidomic Perspective"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Max Nieuwdorp (Amsterdam UMC at University of Amsterdam, The Netherlands)
"Machine Learning"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Daisy Sahoo (Medical College of Wisconsin, United States)
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
The Single Cell Resolution Revolution: From Single Cells to Cell Subsets
Discussion Leader: Vesna Todorovic (Nature Cardiovascular Research, Germany)
6:00 pm - 6:20 pm
Claudia Monaco (University of Oxford, United Kingdom)
"Myeloid Cells in Murine and Human Atherosclerosis: One Cell at a Time"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Chiara Giannarelli (NYU Langone Health, NYU Grossman School of Medicine, United States)
"Single-Cell Approaches Applied to Human Atherosclerosis"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Andreas Zirlik (Medical University Graz, Austria)
"Prognostic Value of Single RNA Sequencing in Identifying Leukocyte Phenotypes Predicting CV Mortality"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Catherine 'Lynn' Hedrick (Augusta University, United States)
"Monocyte Heterogeneity Predicts Human Cardiovascular Risk"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Genetics and Epigenetics
Discussion Leader: Muredach Reilly (Columbia University, United States)
9:00 am - 9:25 am
Heribert Schunkert (Deutsches Herzzentrum München, Germany)
"Multiplicative Effects of Common Risk Alleles"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Casey Romanoski (University of Arizona, United States)
"Systems Genetics of Endothelial Cells for Vascular Disease"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
Willem Mulder (Radboud University Medical Center, The Netherlands)
"Targeting Innate Immunity in Cardiovascular Disease"
11:05 am - 11:15 am
Discussion
11:15 am - 11:40 am
Rajat Gupta (Brigham and Women's Hospital/Harvard Medical School, United States)
"CRISPRi-Perturb-Seq in Endothelial Cells Links Atherosclerosis Risk Loci to Novel KLF2/4 Regulatory Genes"
11:40 am - 11:55 am
Discussion
11:55 am - 12:20 pm
Kelsey Jarrett (UCLA, United States)
"Manipulating Bile Acid Production using Genome Editing to Modulate Cardio-Metabolic Disease"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Hematopoiesis and Reprogramming
Discussion Leader: Hanrui Zhang (Columbia University Irving Medical Center, United States)
6:00 pm - 6:20 pm
Siddhartha Jaiswal (Stanford, United States)
"Clonal Hematopoiesis and Atherosclerotic Cardiovascular Disease"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Andrew Murphy (Baker Heart and Diabetes Institute, Australia)
"High Salt Diet Promotes Atherosclerosis by Altering Hematopoiesis"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Ivan Zanoni (Harvard Medical School - Boston Children's Hospital, United States)
"Endogenous Ligands Reprogram Macrophages to Drive Hyperinflammation"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Yajaira Suarez (Yale University School of Medicine, United States)
"Endothelial ANGPTL4 in Metabolic Reprograming and Atherosclerosis"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
The Vasculature and the Heart
Discussion Leader: Michelle Olive (National Heart, Lung, and Blood Institute, NIH, United States)
9:00 am - 9:20 am
Delphine Gomez (University of Pittsburgh, United States)
"SMC Phenotypes and Functions in Vascular Disease"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Kathleen Martin (Yale University School of Medicine, United States)
"VSMC and Epigenetics"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
Daniela Cihakova (Johns Hopkins University, United States)
"Pathogenesis of Immune Checkpoint Inhibitor Myocarditis"
10:50 am - 11:00 am
Discussion
11:00 am - 11:15 am
Atsushi Anzai (Keio University School of Medicine, Japan)
"Stromal-Immune Crosstalk Underlying Post-Infarction Cardiac Repair"
11:15 am - 11:25 am
Discussion
11:25 am - 11:40 am
Dimitris Tsiantoulas (Medical University of Vienna, Austria)
"Dissecting the Functions of APRIL in Cardiovascular Disease"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Noemi Rotllan Vila (Institut de Recerca de l' Hospital de la Santa Creu i Sant Pau (IIB SANT PAU). CIBERDEM, Spain)
"Tailored sHDL with Bioactive Antiatherosclerotic miRNAs"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Caris Wadding-Lee (The University of Cincinnati, United States)
"Protease Activated Receptor 2 is Critical for Vascular Smooth Muscle Cell Transition to a Macrophage-Like State"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
The Immune System
Discussion Leader: Esther Lutgens (Mayo Clinic, United States)
6:00 pm - 6:20 pm
Oliver Soehnlein (WWU Münster, Germany)
"Neutrophils in Cardiovascular Inflammation: From Physiology to Therapeutic Intervention"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Florent Ginhoux (Gustave Roussy, France)
"Heterogeneity of Tissue-Resident Macrophages"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Christoph Binder (Medical University of Vienna, Austria)
"Defining the Functions and Repertoire of IgM Antibodies in Atherosclerosis"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Elena Galkina (Eastern Virginia Medical School, United States)
"Adaptive Response in Atherosclerosis"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Metabolism, Metabolites and Mitochondria
Discussion Leader: Carlos Fernandez-Hernando (Yale University School of Medicine, United States)
9:00 am - 9:20 am
Eicke Latz (University of Bonn, Germany)
"Reprogramming Macrophage Metabolism by Innate Immune Activation"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Laurent Yvan-Charvet (Inserm, France)
"Crosstalk between Metabolism and Hematopoiesis in Atherosclerosis"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
Babak Razani (University of Pittsburgh and UPMC, United States)
"Lysosomal Nutrient Sensing in Macrophages: A Critical Nexus in the Pathophysiology of Atherosclerosis"
10:50 am - 11:00 am
Discussion
11:00 am - 11:20 am
E. Dale Abel (UCLA David Geffen School of Medicine, United States)
"Mitochondrial Dynamics and Cardiometabolic Disease"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Mireille Ouimet (University of Ottawa Heart Institute, Canada)
"Lipophagy in Atherosclerosis"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Leigh Goedeke (Icahn School of Medicine at Mount Sinai, United States)
"Mitochondria as a Nexus of Lipid Metabolism and Signaling: Implications for Cardiometabolic Disease"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Immunometabolism
Discussion Leader: Klaus Ley (Augusta University, United States)
6:00 pm - 6:20 pm
Musa Mhlanga (Radboud Institute for Molecular Life Sciences, The Netherlands)
"Reprogramming the Epigenomic Landscape During Hematopoiesis"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Marit Westerterp (University Medical Center Groningen, The Netherlands)
"Cholesterol Efflux Pathways and Atherosclerosis"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Katey Rayner (University of Ottawa Heart Institute, Canada)
"Life, Death and Zombies in the Atherosclerotic Plaque"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Luke O'Neill (Trinity College Dublin, Ireland)
"Krebs Cycle Reprogrammed for Immunity and Inflammation"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure