| Saturday |
| 2:00 pm - 5:00 pm | Arrival and Check-in |
| 3:30 pm - 3:45 pm | Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair |
| 3:45 pm - 4:30 pm | Keynote Session: Mechanotransduction and Cardiovascular Disease |
| Discussion Leader: Jie Li (La Jolla Institute for Allergy and Immunology, USA) |
| 3:45 pm - 4:20 pm | Eleni Tzima (University of North Carolina, USA)
"Vascular
Mechanotransduction: A Journey from the Protein to the Vessel" |
| 4:20 pm - 4:30 pm | Discussion |
| 4:30 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Initiation and Progression of Atherosclerosis |
| Discussion Leader: Sylvia Nuernberg (University of Pennsylvania, USA) |
| 7:30 pm - 7:45 pm | Anais Briot (University of California, Los Angeles, USA)
"NOTCH1 Repression Enables Endothelial Activation and Predisposes to Atherosclerosis" |
| 7:45 pm - 7:50 pm | Discussion |
| 7:50 pm - 8:05 pm | Xinmin Li (Cleveland Clinic, USA)
"Elevated Plasma Levels of the Gut Microbial Metabolite TMAO Predict Increased Risk of Myocardial Infarction Among Subjects Presenting with Chest Pain" |
| 8:05 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:25 pm | Esther Smeets (Academic Center Amsterdam, The Netherlands)
"E3 Ubiquitin-Protein Ligase Casitas B Lineage Lymphoma B Deficiency Aggravates Atherosclerosis" |
| 8:25 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:45 pm | Thomas Theelen (Maastricht University Medical Center, The Netherlands)
"Myeloid PHD2 Deficiency Impairs Macrophage Collagen Degradation Stimulating Atherosclerotic Plaque Stability in Mice" |
| 8:45 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:05 pm | Nemanja Vujic (Medical University of Graz, Austria)
"Monoglyceride Lipase Inhibition as Potential Target for Atherosclerotic Plaque Stabilization" |
| 9:05 pm - 9:10 pm | Discussion |
| 9:10 pm - 9:30 pm | General Discussion |
| Sunday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 11:00 am | Atherosclerosis and Its Complications |
| Discussion Leader: Yun Fang (University of Chicago, USA) |
| 9:00 am - 9:15 am | Mark Blaser (University of Toronto, Canada)
"Deficiency of C-Type Natriuretic Peptide Signaling Promotes Aortic Stenosis, Aortic Dilatation, Left Ventricular Dysfunction, and Bicuspid Aortic Valves in Mice" |
| 9:15 am - 9:20 am | Discussion |
| 9:20 am - 9:35 am | Kevin Guedj (INSERM U1148, Laboratory for Vascular Translational Science, France)
"A CD31-Derived Peptide Controls the Recruitment and Function of Blood-Derived Macrophages in the Injured Site After Myocardial Infarction" |
| 9:35 am - 9:40 am | Discussion |
| 9:40 am - 9:55 am | Sandeep Kumar (Emory University, USA)
"Disturbed Flow Stimulates Expression of the microRNA-106b-93-25 Cluster, Which Regulates Flow-Dependent Endothelial Proliferation and Atherosclerosis in Mice" |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am - 10:15 am | Sasha Singh (Brigham and Women's Hospital, USA)
"State-of-the-Art Mass Spectrometry Reveals the Complexity of Protein Distribution and Metabolism Across HDL Sizes" |
| 10:15 am - 10:20 am | Discussion |
| 10:20 am - 10:35 am | Holger Winkels (Ludwig Maximilians University, Munich, Germany)
"Co-Stimulation via CD27 Increases Frequency of Regulatory T Cells and Ameliorates Atherogenesis in Hyperlipidemic Mice" |
| 10:35 am - 10:40 am | Discussion |
| 10:40 am - 10:55 am | Kristen Leslie (Yale University, USA)
"The Role
of OGT in Vascular Smooth Muscle Cell Plasticity" |
| 10:55 am - 11:00 am | Discussion |
| 11:00 am - 12:30 pm | Poster Session |
| Coffee will be served in the poster area from 11:00 am - 11:30 am |
| 12:30 pm | Lunch |
| 1:30 pm - 2:30 pm | Mentorship Component: Career Opportunities in Atherosclerosis Research |
| Discussion Leaders: Yun Fang (University of Chicago, USA) and Sylvia Nuernberg (University of Pennsylvania, USA) |
| 1:30 pm - 2:30 pm | Panel Discussion |
| "Different Career Paths in Academia, Industry and Government" |
|
- Eleni Tzima (University of North Carolina, USA)
- Klaus Ley (La Jolla Institute of Allergy and Immunology, USA)
|
| 2:30 pm - 3:00 pm | Evaluation Period |
| Fill in GRS Evaluation Forms |
| 3:00 pm | Seminar Concludes |
