Saturday
2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Keynote Session: Wanted Dead or Alive: Inflammatory Macrophages in Vascular Disease
Discussion Leader: Andrew Sage (University of Cambridge, United Kingdom)
3:45 pm - 4:25 pm
Katey Rayner (University of Ottawa Heart Institute, Canada)
"Wanted Dead or Alive: Inflammatory Macrophages in Vascular Disease"
4:25 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Lipids, Macrophages and Inflammation
Discussion Leader: Holger Winkels (La Jolla Institute for Allergy and Immunology, USA)
7:30 pm - 7:45 pm
Bastian Ramms (University of California, San Diego, USA)
"Apolipoprotein E Determines the Functional and Atherosclerotic Fate of Apolipoprotein C-III"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
Xin Bi (University of Pennsylvania, USA)
"C6orf106, a Novel Plasma Lipid Locus in Humans, Regulates Lipoprotein Metabolism and Atherogenesis in Mice"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Ada Weinstock (New York University School of Medicine, USA)
"Novel Regulation of Macrophage Polarization and Atherosclerosis Regression by Wnt"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Mandy van Leent (Icahn School of Medicine at Mount Sinai, USA)
"Targeted CD40-TRAF6 Inhibition Resolves Macrophage Accumulation in Atherosclerosis"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Eva Kritikou (Leiden Academic Centre for Drug Research (LACDR), Leiden University, The Netherlands)
"Hypercholesterolemia Induces a Mast Cell-CD4+ T-Cell Interaction in Atherosclerosis"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Cameron McAlpine (Massachusetts General Hospital, USA)
"Sleep Restricts Hematopoiesis and Protects Against Atherosclerosis"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Novel Paradigms for Atherosclerosis Drug Discovery
Discussion Leader: Isabel Schellinger (Heart Research Center Göttingen, Germany)
9:00 am - 9:15 am
Richard Bayliss (University of Virginia, USA)
"SMC Appear to be the Primary Cell Type Responding to IL1β Within Atherosclerotic Lesions"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Shuang Zhang (Northwestern University, USA)
"Mitochondrial-Directed Macrophage Reprogramming During Efferocytosis and Post Myocardial Infarction"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Annelie Shami (Academic Medical Center, University of Amsterdam, The Netherlands)
"GITR Activation Promotes Regulatory CD4+ T-Cell Responses and Stimulates Leukocyte Recruitment in Atherosclerotic Plaques"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Max Senders (Icahn School of Medicine at Mount Sinai, USA)
"Nanobody-Facilitated Multiparametric PET/MRI Phenotyping of Experimental Atherosclerosis"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Vikram Shende (California Institute for Biomedical Research, USA)
"Identification of Small Molecule Suppressors of PCSK9 for the Treatment of Hypercholesterolemia"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
Rhogerry Deshycka (Whitehead Institute for Biomedical Research, USA)
"Engineered Red Blood Cells Carrying PCSK9 Inhibitors as Cholesterol Blockbuster"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Taking the Next Step in Your Research Career
Discussion Leader: Sylvia Nuernberg (University of Pennsylvania, USA)
1:30 pm - 1:50 pm
Michelle Olive (National Heart, Lung, and Blood Institute, NIH, USA)
"Sourcing Support for Your Research"
1:50 pm - 2:00 pm
Discussion
2:00 pm - 2:20 pm
Lauren Celano (Propel Careers, USA)
"Smooth Transitions – Moving to a Career Outside of Academia"
2:20 pm - 2:30 pm
Discussion
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes
