Saturday
2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Keynote Session: Systemic Inflammatory Networks in Atherosclerosis
Discussion Leader: Heather Teague (National Heart, Lung, and Blood Institute, NIH, USA)
3:45 pm - 4:25 pm
Filip Swirski (Massachusetts General Hospital / Harvard Medical School, USA)
"Systemic Inflammatory Networks in Atherosclerosis"
4:25 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Epigenetic and Metabolic Reprogramming In Atherosclerosis
Discussion Leader: Maarten Hulsmans (Massachusetts General Hospital / Harvard Medical School, USA)
7:30 pm - 7:45 pm
Marlies Noz (Radboud University Medical Center, The Netherlands)
"Functional and Metabolic Reprogramming of Bone Marrow Myeloid Cells in Patients with Coronary Atherosclerosis"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
Pei Yu (University Health Network, Canada)
"Engulfment of Oxidized LDL by Macrophages Down-Regulates Sustained Expression of Inflammatory Genes Through Epigenetic Reprogramming"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Heegon Kim (KAIST, South Korea)
"Regression of Atherosclerosis Using Cargo-Switching Nanoparticles"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Wera Pustlauk (Berlin-Brandenburg Center/School for Regenerative Therapies, Charité - Universitätsmedizin Berlin, Germany)
"Osteogenic Differentiation of Human Smooth Muscle Cells as a Model of Vascular Calcification in Atherosclerosis"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Paul "Li-Hao" Huang (Washington University in St. Louis School of Medicine, USA)
"Interstitial Lipoprotein Trafficking Through Lymphatics in Human Autoimmune Disease"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Christopher Chan (Center for Systems Biology, Massachusetts General Hospital, USA)
"Thymic Epithelial Cells Require LXRs to Sustain Proper T Cell Development"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Novel Inflammatory Pathways Modulating Atherosclerosis
Discussion Leader: Jesse Williams (University of Minnesota, USA)
9:00 am - 9:15 am
Marie Depuydt (Leiden Academic Centre for Drug Research, Leiden University, The Netherlands)
"Microanatomy of Advanced Human Atherosclerotic Plaques Through Single-Cell Transcriptomics"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Marco Orecchioni (La Jolla Institute for Immunology, USA)
"The Olfactory Receptor Olfr2 Drives Macrophage IL-1beta Expression and Atherosclerosis"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Adil Rasheed (University of Ottawa Heart Institute, Canada)
"Knockdown of the Mixed Lineage Kinase Domain-Like Protein (MLKL) Enhances Extramedullary Hematopoiesis to Increase Atherosclerosis"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Lindsey Padgett (La Jolla Institute for Immunology, USA)
"Exploring a Novel CD8+ T Cell that Intensifies Cardiovascular Disease and Atherosclerosis"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Myrthe Reiche (Amsterdam UMC, Location AMC, The Netherlands)
"B-Cell CD40 Protects Against Atherosclerosis in Hypercholesterolemic Mice"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
Bandana Singh (Blood Research Institute, Versiti, USA)
"Rap1 Restricts Inflammatory Signaling and Maintains Endothelial Homeostasis, Protecting from the Progression of Atherosclerosis"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Insights into Successfully Obtaining Grants
Discussion Leader: Denuja Karunakaran (University of Queensland, Australia)
1:30 pm - 1:50 pm
Michelle Olive (National Heart, Lung, and Blood Institute, NIH, USA)
"Navigating the NIH Career Development Awards"
1:50 pm - 2:00 pm
Discussion
2:00 pm - 2:20 pm
Natalia Komissarova (National Institutes of Health, USA)
"NIH Grant Review"
2:20 pm - 2:30 pm
Discussion
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes