Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:00 pm - 3:15 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:15 pm - 4:00 pm
Keynote Session: A Fresh Perspective on Atherosclerosis - The Role of Complement
Discussion Leader: Redouane Aherrahrou (University of Virginia/University of Luebeck/University of Eastern Finland, Germany)
3:15 pm - 3:25 pm
General Discussion
3:25 pm - 3:50 pm
Claudia Kemper (National Institutes of Health, United States)
"Complement and Complosome - An Old Dog Still Bites"
3:50 pm - 4:00 pm
Discussion
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Molecular Mechanisms of Cardiometabolic Disease
Discussion Leaders: Sabrina Robichaud (University of Ottawa Heart Institute, Canada) and Tarik Zahr (Columbia University, United States)
5:30 pm - 5:45 pm
Johannes Gollmer (Medical University Graz, Austria)
"Molecular Alterations of Human Diabetic Heart Disease Revealed using Single Nucleus Sequencing"
5:45 pm - 5:50 pm
Discussion
5:50 pm - 6:05 pm
Tom Collins (Baker Heart and Diabetes Institute, Australia)
"Exploring How Cardiometabolic Disease Impacts the Immune Cell Lipidome"
6:05 pm - 6:10 pm
Discussion
6:10 pm - 6:25 pm
Teresa Gerhardt (Icahn School of Medicine at Mount Sinai, United States)
"Coronary Culprit Plaque Morphology Determines Residual Inflammatory Risk and Outcome – Novel Aspects Towards Precision Prevention Following Acute Coronary Syndrome"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:45 pm
Rachel Carley (Brown University, United States)
"Rac1 and NF-kB Signaling Regulate Macrophage Expression of IL-1ß and Atherosclerotic Calcification: Implications for Targeted Therapies"
6:45 pm - 6:50 pm
Discussion
6:50 pm - 7:05 pm
Megan Mulholland (Lund University, Sweden)
"IL1RAP Blockade Limits Development of Atherosclerosis and Reduces Plaque Inflammation"
7:05 pm - 7:10 pm
Discussion
7:10 pm - 7:25 pm
Gage Stuttgen (Medical College of Wisconsin, United States)
"FFAR4 Regulates Macrophage Metabolism and Foam Cell Formation"
7:25 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Cells of the Vessel Wall and Metabolic Determinants of Cardiovascular Disease
Discussion Leaders: Kelsey Jarrett (UCLA, United States) and Corey Scipione (University Health Network, Canada)
9:00 am - 9:15 am
Tamara Vico (University Heart Center Freiburg-Bad Krozingen, Germany)
"Recruited and Resident Cardiac Macrophage Phenotypes Converge in the Healing Infarct but not in the Failing Heart Exposed to Continuous Pressure Overload"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Allen Chung (Columbia University, United States)
"The Matrix Metalloproteinase ADAMTS7 Increases Foam Cell Formation and Atherosclerosis"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Sneha Raju (University of Toronto , Canada)
"Endothelial Cells Communicate with Surrounding Vascular Cells via Bidirectional and Polarized Secretion of Extracellular Vesicular Cargo: Implications for Atherosclerotic Plaque Development"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Jared Elenbaas (Washington University in St. Louis, United States)
"The Cardiometabolic Disease Risk Protein SVEP1 Signals Through the Orphan Receptor PEAR1"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Rosalie W.M. Kempkes (Amsterdam UMC, The Netherlands)
"EZH2 Inhibition Reduces Macrophage Inflammatory Responses in Atherosclerosis"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
Yasemin Zurke (University of Oxford, United Kingdom)
"Macrophage Heterogeneity in Metabolic Disease"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Insights Into Successfully Obtaining Grants
Discussion Leader: Mabruka Alfaidi (LSU Health – Shreveport, United States)
1:30 pm - 1:55 pm
Michelle Olive (National Heart, Lung, and Blood Institute, NIH, United States)
"Navigating the NIH Career Development Awards"
1:55 pm - 2:00 pm
Discussion
2:00 pm - 2:25 pm
Andrew Murphy (Baker Heart and Diabetes Institute, Australia)
"High Dietary Salt Promotes a TH17 Cell Driven Gut-Bone Axis to Regulate Haematopoiesis and Atherosclerosis"
2:25 pm - 2:30 pm
Discussion
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes
