Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Attention, Prospects and Lessons for the Auditory System
Discussion Leader: Jeffrey Holt (Harvard Medical School / Boston Children's Hospital, USA)
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
Charles Liberman (Massachusetts Eye and Ear Infirmary, USA)
"Cochlear Synaptopathy in Acquired Sensorineural Hearing Loss: Research Progress and Therapeutic Prospects"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Barbara Shinn-Cunningham (Boston University, USA)
"Control of Spatial and Non-Spatial Auditory Attention"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Jean Bennett (University of Pennsylvania, USA)
"Retinal Gene Therapy and Lessons for the Auditory System"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Building and Rebuilding Auditory Transduction
Discussion Leader: Anthony Peng (University of Colorado Denver, USA)
9:00 am - 9:20 am
Teresa Nicolson (Oregon Health & Science University, USA)
"The MET Complex in Zebrafish"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Guy Richardson (University of Sussex, United Kingdom)
"The Tectorial Membrane, a Matrix Required for Normal Hearing: Effects of Mutations and Ageing"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Peter Narins (University of California, Los Angeles, USA)
"Contributions of Internally Coupled Ears to Localization and Auditory Sensitivity Reduction in Frogs"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
Selected from Poster Abstracts: Nurunisa Akyuz (Harvard Medical School, USA)
"Structural Features of the Hair-Cell Transduction Channel"
11:10 am - 11:15 am
Discussion
11:15 am - 11:25 am
Selected from Poster Abstracts: Bifeng Pan (Boston Children's Hospital / Harvard Medical School, USA)
"Identification of the Pore Region of TMC1 Using Cysteine Mutagenesis"
11:25 am - 11:30 am
Discussion
11:30 am - 11:50 am
Tobias Moser (University of Goettingen, Germany)
"Optogenetic Restoration of Hearing"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Selected from Poster Abstracts: Kevin Booth (University of Iowa, USA)
"Old Gene, New Phenotype: Splice-Altering Variants in CEACAM16 Cause Recessive Non-Syndromic Hearing Impairment"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Ruth Litovsky (University of Wisconsin-Madison, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Genetics of Auditory Function and Dysfunction
Discussion Leader: Lisa Goodrich (Harvard Medical School, USA)
7:30 pm - 7:50 pm
Selected from Poster Abstracts: Brikha Shrestha (Harvard Medical School, USA)
"Diversification of Type I Spiral Ganglion Neurons by IHC-Driven Activity"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Neil Segil (University of Southern California, USA)
"Epigenetic Mechanisms Governing Development and Failure of Regeneration in the Inner Ear"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Troy Hackett (Vanderbilt University Medical Center, USA)
"Transcriptome Profiling in the Auditory Pathway: Characterizing Genomic Change in Development, Aging and Pathology"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Christine Petit (Institut Pasteur, France)
"Hidden Cortical Deficits in Hereditary Deafness"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Physiology and Pathology of Auditory Synapses
Discussion Leader: Larry Trussell (Oregon Hearing Research Center, Oregon Health and Science University / Vollum Institute, USA)
9:00 am - 9:20 am
Elisabeth Glowatzki (Johns Hopkins University, USA)
"Modulation of Hair Cell Afferent Transmission by Lateral Efferent Fibers"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Paul Manis (University of North Carolina at Chapel Hill, USA)
"Quantitative Analyses of Synaptic Connectivity in the Cochlear Nucleus"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Maria Geffen (University of Pennsylvania, USA)
"Cortical Circuits for Dynamic Auditory Perception"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
Selected from Poster Abstracts: Matthew Fischl (National Institute on Deafness and Other Communication Disorders, NIH, USA)
"Medial Olivocochlear Neurons Receive Inhibitory Input from the Medial Nucleus of the Trapezoid Body"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
Don Caspary (Southern Illinois University School of Medicine, USA)
"Attention and Aging in Auditory Thalamus: Cholinergic Transmission and Predictive Coding"
11:35 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Jeffry Isaacson (University of California, San Diego, USA)
"Cortical Circuits Underlying Audition"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Unique Connections in the Auditory Pathways
Discussion Leader: Ruth Anne Eatock (University of Chicago, USA)
7:30 pm - 7:50 pm
Katie Kindt (National Institute on Deafness and Other Communication Disorders, NIH, USA)
"Gap Junction Networks Facilitate Presynaptic Activity in Lateral-Line Hair Cells"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
George Spirou (West Virginia University, USA)
"Cochlear Nucleus Connectome: A Platform to Study the Mammalian Auditory System"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Jennifer Groh (Duke University, USA)
"The Eardrum Moves When the Eyes Move: A Multisensory Effect on the Mechanics of Hearing"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Selected from Poster Abstracts: Srivatsun Sadagopan (University of Pittsburgh, USA)
"Cortical Mechanisms Supporting Complex Sound Processing"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Auditory Plasticity Following Auditory Pathology
Discussion Leader: Dan Sanes (New York University, USA)
9:00 am - 9:20 am
Karl Kandler (University of Pittsburgh, USA)
"Plasticity of Intrinsic Circuits in the Inferior Colliculus"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Selected from Poster Abstracts: David Schneider (New York University, USA)
"A Cortical Filter Learns and Suppresses the Acoustic Consequences of Movement"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Stephen Lomber (University of Western Ontario, Canada)
"Plasticity in Auditory Cortex Following Hearing Loss"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Anne Takesian (Massachusetts Eye and Ear Infirmary, USA)
"Inhibitory Circuit Gating of Auditory Cortical Plasticity"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Jonathan Fritz (University of Maryland, USA)
"Attention-Driven Transformations in Auditory Processing"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Selected from Poster Abstracts: Erin Glennon (New York University School of Medicine, USA)
"Neuromodulation and Plasticity for a Rodent Model of Cochlear Implant Use"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Novel Approaches for Investigating the Auditory System
Discussion Leader: Ronna Hertzano (University of Maryland School of Medicine, USA)
7:30 pm - 7:50 pm
Amanda Janesick (Stanford University School of Medicine, USA)
"Chicken Inner Ear Hair Cell Regeneration at High Temporal and Spatial Resolution"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Allison Coffin (Washington State University, USA)
"From Fins to Fur: Drug Development for Hearing Protection"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Selected from Poster Abstracts: Michael Roberts (University of Michigan, USA)
"Identification of Novel Neuron Classes in the Inferior Colliculus"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
Matthew Kelley (National Institute on Deafness and Other Communication Disorders, NIH, USA)
"Examining Inner Ear Development Using Single Cell RNAseq"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Selected from Poster Abstracts: Ramnarayan Ramachandran (Vanderbilt University Medical Center, USA)
"The Development of a Nonhuman Primate Model for Noise Induced Hearing Loss"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Emerging Therapies for Auditory Restoration
Discussion Leader: Gwenaelle Geleoc (Boston Children's Hospital, USA)
9:00 am - 9:20 am
Rene Gifford (Vanderbilt University, USA)
"Combined Electric and Acoustic Stimulation: Mechanisms Driving Patient Benefit"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Karl Koehler (Indiana University, USA)
"Directed Self-Assembly of Human Inner Ear Organoids"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Selected from Poster Abstracts: Hela Azaiez (University of Iowa, USA)
"The Deafness Variation Database: A Deafness-Specific Comprehensive Platform for the Classification and Dissemination of Genetic Variants"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Rachael Richardson (Bionics Institute, Australia)
"Novel Therapies for Protecting and Regenerating Sensory Cells in the Cochlear After Hearing Loss"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Selected from Poster Abstracts: Carl Nist-Lund (Boston Children's Hospital, USA)
"Next Generation Gene Therapy Restores Hearing and Balance in Mouse Models of Genetic Inner Ear Disorder"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Xi Lin (Emory University, USA)
"Major Barriers to Overcome for Translational Success of Cochlear Gene Therapy"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Selected from Poster Abstracts: Stephen McInturff (Massachusetts Eye and Ear Infirmary, USA)
"Electrical Stimulation of the Dorsal Cochlear Nucleus: Effects of Dorsal Acoustic Stria Cuts"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Regulation and Dysregulation of Auditory Pathways
Discussion Leader: Dave Raible (University of Washington, USA)
7:30 pm - 7:50 pm
Donna Fekete (Purdue University, USA)
"Zika Virus Infection During CNS and Inner Ear Development"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Conny Kopp-Scheinpflug (University of Munich, Germany)
"Axon-Glia Communication During Activity Dependent Regulation of Axonal Conduction"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Mark Warchol (Washington University School of Medicine, USA)
"Cochlear Macrophages Influence the Survival of Auditory Neurons"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Selected from Poster Abstracts: Melissa Caras (New York University, USA)
"Increasing Inhibitory Gain During Development Enhances Perception"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure