Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Plasma Membrane Processes
Discussion Leader: Nina Salama (Fred Hutchinson Cancer Research Center, USA)
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
Jeff Errington (Newcastle University, United Kingdom)
"L-Form Bacteria: Genetics, Cell Cycle and Recurrent Infection"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Paula Welander (Stanford University, USA)
"Biosynthesis of Membrane Lipids in Sulfolobus acidocaldarius "
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
Leonid Sazanov (Institute of Science and Technology Austria, Austria)
"Coupling Mechanism of Respiratory Complex I"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Timothy Knowles (University of Birmingham, United Kingdom)
"Rethinking the Mla Pathway: Evidence for Anterograde Lipid Trafficking"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Building the Cell Wall
Discussion Leader: Eefjan Breukink (Utrecht University, The Netherlands)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Martin Loose (Institute of Science and Technology Austria, Austria)
"Self-Organization of the Bacterial Cell Division Machinery"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
Mariana Pinho (Instituto de Tecnologia Quimica e Biologica, Universidade NOVA de Lisboa, Portugal)
"Coordination Between Peptidoglycan Synthesis and Cell Division"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
Michael Vannieuwenhze (Indiana University, USA)
"Recent Developments with Fluorescent D-Amino Acids and Their Utility in the Study of Bacterial Cell Division"
11:15 am - 11:25 am
Discussion
11:25 am - 11:50 am
Alessandra Polissi (University of Milano, Italy)
"Peptidoglycan Remodeling Enables E. coli to Survive Severe Outer Membrane Assembly Defects"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Alexander Egan (Centre for Bacterial Cell Biology, Newcastle University, United Kingdom)
"Induced Conformational Changes Activate the Bifunctional Peptidoglycan Synthase PBP1B"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Megan Sjodt (Harvard Medical School, USA)
"Structure and Function of the SEDS:bPBP Bacterial Cell Wall Synthesis Machinery"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cell Division and Morphogenesis
Discussion Leader: Tanneke Den Blaauwen (University of Amsterdam, The Netherlands)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Malcolm Winkler (Indiana University Bloomington, USA)
"Movement Dynamics of Proteins that Mediate and Regulate Peptidoglycan Synthesis in Cells of Streptococcus pneumoniae "
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Hesper Rego (Yale University, USA)
"Asymmetry and Heterogeneity in Mycobacterial Growth and Division"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
Zemer Gitai (Princeton University, USA)
"Bacterial Shape and Cytoskeletal Regulation"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Riti Mann (University of Technology Sydney, Australia)
"We Are What We Eat: Identifying a Regulatory Crosstalk Between Central Carbon Metabolism and Cell Division in Bacteria"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
A Dynamic Cell Wall
Discussion Leader: Kerwyn Huang (Stanford University, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Ethan Garner (Harvard University, USA)
"New Feedback Loops Controlling Cell Width and Growth"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
Jan-Willem Veening (University of Lausanne, Switzerland)
"Identification of a Unique Cell Cycle Regulator in Streptococcus pneumoniae by En Masse GFP Localization, Tn-Seq and CRISPRi Phenotyping"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
Tanja Schneider (University of Bonn, Germany)
"Integration of Capsule Formation into the Cell Wall Biosynthetic Network"
11:15 am - 11:25 am
Discussion
11:25 am - 11:50 am
Enrique Rojas (New York University, USA)
"The Mechanical Properties of the Outer Membrane"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Kelsi Sandoz (Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH, USA)
"Covalent Attachment of Porins to Peptidoglycan Promotes Cell Envelope Stability in the Absence of Braun's Lipoprotein"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Jason Peters (University of California, San Francisco, USA)
"CRISPR-Based Dissection of Bacterial Cell Wall Pathways"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Outer Membrane Biogenesis and Function
Discussion Leader: Stephen Trent (University of Georgia, USA)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Damian Ekiert (New York University School of Medicine, USA)
"Architectures of Lipid Transport Systems for the Bacterial Outer Membrane"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Sheena Radford (University of Leeds, United Kingdom)
"Folding and Assembly of Proteins into the Outer Membrane of E. coli "
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
Bert van den Berg (Newcastle University, United Kingdom)
"Nutrient Acquisition by the Human Gut Microbiota"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Shu Sin Chng (National University of Singapore, Singapore)
"Biosynthetic Intermediates of an Exopolysaccharide Exhibit Stabilizing Effects on the Outer Membrane in Escherichia coli "
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cell Envelope Macromolecular Machines
Discussion Leader: Judith Armitage (University of Oxford, United Kingdom)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Ben Luisi (University of Cambridge, United Kingdom)
"Structure and Mechanism of Bacterial Multi-Drug Efflux Pumps"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
Trevor Lithgow (Monash University, Australia)
"The Assembly of Protein Secretion Systems into the Bacterial Outer Membrane"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
Jun Liu (Yale University, USA)
"In Situ Structure and Function of Bacterial Secretion Machines"
11:15 am - 11:25 am
Discussion
11:25 am - 11:50 am
Marek Basler (University of Basel, Switzerland)
"Bacterial Type VI Secretion System: From Structure to Dynamics and Function"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Ben Berks (University of Oxford, United Kingdom)
"Type IX Protein Secretion"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Marcin Grabowicz (Emory University, USA)
"Chemical Biology Insights into Outer Membrane Protein Biogenesis"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Cell Surfaces: A Barrier and a Target for Antibacterials
Discussion Leader: Jeff Errington (Newcastle University, United Kingdom)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Suzanne Walker (Harvard Medical School, USA)
"Regulation of Peptidoglycan Synthesis in Staphylococcus aureus "
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Jennifer Leeds (Novartis Institutes for BioMedical Research, USA)
"Discovery and Early Development of LYS228"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
Athanasios Typas (European Molecular Biology Laboratory, Germany)
"Species-Specific Activity of Drug Combinations"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Roman Dziarski (Indiana University, USA)
"Human Peptidoglycan Recognition Proteins Kill Bacteria by Inducing Oxidative Stress Through a Block in the Respiratory Chain"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Bacterial Communities/Microbiome
Discussion Leader: Melanie Blokesch (Swiss Federal Institute of Technology Lausanne (EPFL), Switzerland)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Bonnie Bassler (Princeton University, USA)
"Bacterial Quorum Sensing and Its Control"
9:35 am - 9:45 am
Discussion
9:45 am - 9:55 am
Katarzyna Mickiewicz (Centre for Bacterial Cell Biology, Newcastle University, United Kingdom)
"L-Form Switching as a Potential Mechanism for the Recurrence of Urinary Tract Infections"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
Georgia Isom (NYU Langone Medical Center, USA)
"Deciphering a Mechanism of Lipid Transport for the Bacterial Outer Membrane"
10:10 am - 10:15 am
Discussion
10:15 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
Matt Traxler (University of California, Berkeley, USA)
"Genetic Control of Specialized Metabolism During Actinomycete Interactions"
11:15 am - 11:25 am
Discussion
11:25 am - 11:50 am
Andrew Goodman (Yale University, USA)
"Vitamin Capture by Human Gut Microbes"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Salim Islam (INRS-Institut Armand-Frappier Research Centre, Canada)
"Integrin-Like Tethering of Motility Complexes at Bacterial Focal Adhesions"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Sloan Siegrist (University of Massachusetts Amherst, USA)
"Membrane Partitioning of Mycobacterial Peptidoglycan Synthesis"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cell Biology of the Envelope
Discussion Leader: Elizabeth Sockett (University of Nottingham, United Kingdom)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Arash Komeili (University of California, Berkeley, USA)
"Lipid-Bounded Organelles in Bacteria"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Jade Wang (University of Wisconsin-Madison, USA)
"(p)ppGpp Mediates Antibiotic Tolerance in Gram-Positive Bacteria"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
Alan Grossman (Massachusetts Institute of Technology, USA)
"Crossing Boundaries: Promiscuity and Exclusivity in Bacterial Sex"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Yu-Ling Shih (Academia Sinica, Taiwan)
"Synchronizing Min Oscillation with Nutrient Availability in Escherichia coli "
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure