Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Exploring the Bacterial Cell Envelope
Discussion Leader: Rut Carballido-Lopez (Paris-Saclay University - INRAE - AgroParisTech , France)
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:00 pm
Introduction by Discussion Leader
8:00 pm - 8:20 pm
Thomas Silhavy (Princeton University, United States)
"Phospholipid Transport to and From the Outer Membrane"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Waldemar Vollmer (Newcastle University, United Kingdom)
"Coordination of Cell Envelope Biogenesis"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Christine Jacobs-Wagner (Stanford University, United States)
"Alexander M. Cruickshank Lecture: Lyme Disease and the Peptidoglycan"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Modifying the Bacterial Cell Surface
Discussion Leader: Jean-Francois Collet (UCLouvain, Belgium)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Filippo Mancia (Columbia University, United States)
"Structural Basis of Lipopolysaccharide Maturation"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
Felipe Cava (Umea University, Sweden)
"Genome-Wide Vibrio cholerae Peptidoglycan Profiling"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
Gregory Bokinsky (TU Delft, The Netherlands)
"Membrane Detection Mechanisms Establish Feedback Loops that Separately Maintain Phospholipid and Lipopolysaccharide Homeostasis in Escherichia coli"
11:15 am - 11:25 am
Discussion
11:25 am - 11:50 am
Aimee Shen (Tufts University School of Medicine, United States)
"Mechanisms Controlling Spore Cortex Modification in Clostridioides difficile "
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Antonella Fioravanti (Structural and Molecular Microbiology group, Structural Biology Research Center-VIB, Belgium)
"The Bacillus anthracis S-layer is an Exoskeleton-Like Structure that Imparts Mechanical and Osmotic Stabilization to the Cell Wall"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Matthew Doyle (The University of Sydney, Australia)
"Beta-Barrel Folding within the Gram-negative Outer Membrane"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Erin Goley (Johns Hopkins University School of Medicine, United States) and Mario Feldman (Washington University School of Medicine, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cell Division and Morphogenesis
Discussion Leader: Simon Foster (University of Sheffield, United Kingdom)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Thomas Bernhardt (Harvard Medical School, United States)
"Regulation of Envelope Assembly in Gram-Negative Bacteria"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Erin Goley (Johns Hopkins University School of Medicine, United States)
"Constriction Activation by FzlA Links Division to Chromosome Segregation in Caulobacter "
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
Kumaran Ramamurthi (National Cancer Institute, NIH, United States)
"Developmental Checkpoint that Directly Monitors Cell Surface Morphogenesis"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Thomas Bartlett (Harvard Medical School, United States)
"Discovery and Characterization of Firmicute Division Protein FacZ"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Stress Responses and Signaling Across the Cell Envelope
Discussion Leader: Marcin Grabowicz (Emory University, United States)
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:40 am
Tam Mignot (CNRS-Aix Marseille University, France)
"Motility Equipped with a Sense of Touch in Predatory Bacteria"
9:40 am - 9:50 am
Discussion
9:50 am - 10:00 am
Elizabeth Hart (Harvard Medical School, United States)
"Characterizing the Corynebacterial Sigma D Cell Envelope Stress Response"
10:00 am - 10:05 am
Discussion
10:05 am - 10:15 am
Jan-Samuel Puls ( University Hosptial Bonn, University of Bonn, Germany)
"The Novel Epilancin A37 Destabilizes Bacterial Membranes and Induces Intracellular Vesicle Formation"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
Alexandre Persat (École Polytechnique Fédérale de Lausanne, Switzerland)
"Mechanosensing with Type IV Pili"
11:15 am - 11:25 am
Discussion
11:25 am - 11:50 am
Anna Konovalova (University of Texas Health Science Center at Houston, United States)
"Gaining Exposure: Localization and Function of the Surface Sensor RcsF"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Jacob Bouchier (University of Missouri, United States)
"Activation of a Plant Invasion Switch by Cell Wall Stress in Agrobacterium tumefaciens "
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Arne Janssens (Vrije Universiteit Brussel (VUB), Belgium)
"SlyB Compartmentalizes the Outer Membrane Proteome into Stress-Induced Lipid Nanodomains"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Mechanisms of Surface Recognition
Discussion Leader: Daniel Wall (University of Wyoming, United States)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Andrew Lovering (University of Birmingham, United Kingdom)
"Mechanisms Underpinning Bacterial Predation by Bdellovibrio"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Serge Mostowy (London School of Hygiene and Tropical Medicine, United Kingdom)
"Use of the Cytoskeleton to Control Shigella Infection"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
Andrea Wolf (Cedars-Sinai Medical Center, United States)
"The Importance of Metabolic Proteins in the Recognition of Bacterial Cell Wall Peptidoglycan"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Sujeet Kumar (The Ohio State University, United States)
"Identification of Putative Phospholipid Transporters that Build the Outer Membrane"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Transport through the Envelope
Discussion Leader: Natividad Ruiz (Ohio State University, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Lori Burrows (McMaster University, Canada)
"Pumping Iron - Exploitation of TonB-Dependent Receptors by Antimicrobials"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
Matthew Waldor (Brigham and Women's Hospital / Harvard University, United States)
"Candidate Undecaprenyl Phosphate Translocases Enable Conditional Microbial Fitness and Pathogenesis"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
Jorge Galan (Yale School of Medicine, United States)
"The Virulence-Associated Type III Secretion System of Salmonella "
11:15 am - 11:25 am
Discussion
11:25 am - 11:50 am
Georgina Cox (University of Guelph, Canada)
"Construction of a Genetic Platform to Investigate the Functions of Bacterial 'Drug' Efflux Pumps"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Kyrie Grasekamp (Institut Pasteur, France)
"Bridges Instead of Boats? Investigating Phospholipid Trafficking in an Unusual Diderm Firmicute"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Kévin Macé (Birkbeck University, United Kingdom)
"Type IV Secretion System Cyro-EM Structure"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
7:30 pm - 9:30 pm
Protein Secretion and Transport
Discussion Leader: Edith Houben (Vrije Universiteit Amsterdam, The Netherlands)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Melanie Blokesch (EPFL, Switzerland)
"No Matter How – Pandemic V. cholerae do it in a Different Way"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Mario Feldman (Washington University School of Medicine, United States)
"Shedding Light on OMV Shedding"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
Tracy Palmer (Newcastle University, United Kingdom)
"The Staphylococcus aureus Type VII Secretion System"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Nadia Herrera (University of California San Francisco, United States)
"The Type VII Secretion System, ESX-1, Exhibits Bi-Modular Function in Mycobacteria in Response to Nitrogen"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
How the Surface Influences Bacterial Communities
Discussion Leader: Lotte Sogaard-Andersen (Max Planck Institute for Terrestrial Microbiology, Germany)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Peggy Cotter (University of North Carolina at Chapel Hill, United States)
"Bordetella Filamentous Hemagglutinin: Adhesin, Immunomodulator, and Phagocyte-Specific Toxin Delivery"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
Urs Jenal (University of Basel, Switzerland)
"Cellular Individuality in Surface Colonization of a Human Pathogen"
10:10 am - 10:20 am
Discussion
10:20 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
Nicole Koropatkin (University of Michigan Medical School, United States)
"TonB-Dependent Import of Glycans in Human Gut Bacteroides "
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Charlène Cornilleau (INRAE, France)
"Differential Effect of Peptidoglycan Synthesis Inhibitors on the Cell Wall Elongation Machineries"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Julia Page (Harvard Medical School, United States)
"A Recurrent Strategy for Activating Peptidoglycan Amidases"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Merel Damen (Vrije Universiteit Amsterdam, The Netherlands)
"The ESX-1 Substrate PPE68 has a Key Function in the ESX-1 Mediated Secretion in Mycobacterium marinum "
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Krista Armbruster (University of Michigan Medical School, United States)
"Identification and Characterization of the Lipoprotein N-acyltransferase Gene in Bacteroides"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Biophysical Methods to Improve Antimicrobial Therapies
Discussion Leader: Pamela Brown (University of Missouri, United States)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Kerwyn Huang (Stanford University, United States)
"Mechanisms of Cell Shape Determination in Human Gut Commensals"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Steven Rutherford (Genentech, United States)
"Interfering with Outer Membrane Biogenesis"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
Jie Xiao (Johns Hopkins University School of Medicine, United States)
"A Potential Activation Mechanism for Septal Cell Wall Synthesis in E. coli "
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Georgina Benn (Princeton University, United States)
"Phase Separation in the Outer Membrane of Escherichia coli "
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure