Sunday 18.4
2:00 - 6:00 pm Registration
6:00 pm Dinner
7:30 - 9:30 pm Evening Session
7:30 - 7:40 Introductory Remarks (Hans Schaefer, Clichy/France, Chair) (Bruno Giannasi, IL Ciocco, Local Manager)
Optical properties (Christopher Cullander, San Francisco/US, Vice Chair)
| 7:40 - 8:00 |
Pierre Corcuff, Aulnay-sous-Bois/France
"Optical Properties of the Skin Revisited by in vivo Confocal Microscopy" |
| 8:15 - 8:35 |
Mark Orazem, Gainesville/US
"Characterization of Transdermal Delivery in-vitro using Optical and Electrochemical Impedance" |
| 8:50 - 9:10 |
Robert Imhof, London/United Kingdom
"Opto-Thermal in-vivo Transdermal Diffusion Measurement" |
9:30 pm Welcome Reception (Italian Wine and Cheese)
Monday 19.4
9:00 - 12:30 am Morning Session
Barrier Formation (Hans Schaefer, Clichy/France, Chair)
| 9:00 - 9:20 |
Gonneke Pilgram, Leiden/Netherlands
"Electron Diffraction: a New Tool to Establish the Lateral Lipid Packing of Human Stratum Corneum in vivo and ex vivo" |
| 9:35 - 9:55 |
Theodora Mauro, San Francisco/US
"Ionic Gradients in the Skin" |
| 10:10 - 10:30 |
Richard Eckert, Cleveland/US
"Calcium, S 100 Proteins and Cornified Envelope Formation" |
10:45-11:15am - Photograph and Coffee Break
| 11:15 - 11:35 |
Peter Steinert, Bethesda/US
"Enzymatic Attachment of Ceramides to the Cornified Cell Envelope" |
| 11:50 - 12:10 |
Kenneth Feingold, Sans Francisco/US
"Regulation of Keratinocyte Differentiation and Barrier Development by PPAR and FXR Activators" |
12:30 - Lunch
4:30 pm Coffee and Cookies
Monday 19.4
5:30 - 7:30 pm Evening Session
Modeling (Neil Kitson, Vancouver/Canada, Chair)
| 5:30 - 5:50 |
Jonathan Hadgraft, Cardiff/United Kingdom
"Physicochemical Determinants of Skin Penetration" |
| 6:05 - 6:25 |
Bo Michniak, Columbia/US
"In vitro Activities of Novel Dermal Penetration Enhancers" |
| 6:40 - 7:00 |
William van Osdol, Palo Alto/US
"Predictive Modeling of Permeation Enhancement" |
| 7:15 - 7:35 |
Thomas Magin, Düsseldorf/Germany
"Barrier Defects in Keratin 10-Deficient Mice" |
8:00 pm Dinner
9:15 pm Poster
Tuesday 20.4
9:00 - 12:00 am Morning Session
Models/Methods (Maja Ponec, Leiden/Netherlands, Chair)
| 9:00 - 9:20 |
Isabelle Castiel, Clichy/France
"Lipid Synthesis and Barrier Function of Reconstructed Skin" |
| 9:35 - 9:55 |
Esther Schnetz, Erlangen/Germany
"Microdialysis as a Tool for in vivo and in vitro Studies of Percutaneous Penetration" |
| 10:10 - 10:30 |
Esther Boelsma, Leiden/Netherlands
"Skin Microdialysis as a Tool to Measure Percutaneous Penetration in Human Skin in vitro" |
10:45-11:15am - Coffee Break
| 11:15 - 11:35 |
Delphine Imbert, Foster City/US
"Characterization of Physical and Enzymatic Barriers in Porcine Buccal Mucosa in vitro" |
| 11:50 - 12:10 |
Dennis Roop, Houston/US
"Transgenic Mouse Models Exhibiting Loss of Epidermal Barrier Function" |
12:30 pm Lunch
4:30 pm Coffee and Cookies
Tuesday 20.4
5:30-7:30pm - Evening Session
Pathology and Repair of the Barrier (Manigé Fartasch, Erlangen/Germany, Chair)
| 5:30 - 5:50 |
Steven Hoath, Cincinnati/US
"Considerations on the Role of the Stratum Corneum as the Boundary of an Autopoetic System" |
| 6:05 - 6:25 |
Ehrhardt Proksch, Kiel/Germany
"Signaling in Barrier Repair"
|
| 6:40 - 7:00 |
Paul Robbins, Stanford/US
"Achieving Lasting Genetic Correction of Inherited Disorders of Cornification" |
8:00 pm - Dinner
9:15 pm - Poster
Wednesday 21.4
9:00 - 12:30 am Morning Session
Exobiotics/Defense (Jens Thiele, Düsseldorf/Germany, Chair)
| 9:00 - 9:20 |
Peter Elsner, Jena/Germany
"Barrier Against Microorganisms" |
| 9:35 - 9:55 |
Gary Darmstadt, Seattle/US
"Antimicrobial Barrier Function of the Skin" |
| 10:10 - 10:30 |
Mitsuhiro Denda, Yokohama/Japan
"The Effect of Environment on Permeability Barrier Homeostasis and Epidermal Proliferation" |
10:45 - 11:15 am - Coffee Break
| 11:15 - 11:35 |
Karen Burke, New York/US
"The Penetration and Efficacy of the Topical Antioxidants l-Selenomethionine and d-alpha Tocopherol" |
| 11:50 - 12:10 |
Jean Krutmann, Düsseldorf
"The Role of Ceramides in Ultraviolet A Radiation-Induced Gene Expression in Human Keratinocytes" |
12:30 pm Lunch
4:30 pm Coffee and Cookies
Wednesday 21.4
5:30 - 7:30 pm Business Meeting
8:00 pm Dinner
9:15 - 10:30 pm - Debate
Quantitative Structure Penetration Relations, Do They Predict The Real Thing?
Moderator : Bo Forslind, Stockholm/Sweden
Pro Team : Jonathan Hadgraft, Cardiff/UK
Con Team : Jean-Paul Marty, Châtenay-Malabry/France
Thursday 22.4
9:00 - 12:30 am Morning Session
Tape-Stripping (Joke Bouwstra, Leiden/Netherlands, Chair)
| 9:00 - 9:20 |
Jürgen Lademann, Berlin, Germany
"Penetration of Titanium Dioxide Particles into the Barrier" |
| 9:35 - 9:55 |
Graham Bench, Livermore/US
"A Quantitative Minimally Invasive Assay for the Detection of Metals in the Stratum Corneum" |
| 10:10 - 10:30 |
Yogi Kalia, Archamps/France
"Calculating Transport Parameters as a Function of Depth within Human Stratum Corneum in vivo" |
10:45 - 11:15 Coffee Break
| 11:15 - 11:35 |
Jurij Hostynek, San Francisco/US
"Penetration Gradient of Nickel and its Salts Absorbed in Human Stratum Corneum in vivo" |
| 11:50 - 12:10 |
Jean-Paul Marty, Châtenay-Malabry/France
"Tape Stripping and Sunscreen Dermatopharmacokinetics" |
12:30 pm Lunch
4:30 pm Coffee and Cookies
Thursday 22.4
5:30 - 7:30 pm - Evening Session
Hot news (Patrizia Santi, Parma/Italy, Chair)
| 5:30 - 5:40 |
Vera Morhenn, California Skin Research Institute, San Diego/ USA.
"A New Method for Distinguishing Irritant and Allergic Reactions of the Skin" |
| 5:50 - 6:00 |
Julia Segre, HHMI, Univ of Chicago, Chicago/US
"Transcriptional Regulation of Hair Follicle Development and Differentiation" |
| 6:10 - 6:20 |
Bradley Bath, Univ. of Utah, Salt Lake City/US
"Mechanistic Analysis of Molecular Transport through Skin During Iontophoresis" |
8:00 pm Dinner
9:15 pm Poster
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