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Barrier Function of Mammalian Skin

Gordon Research Conference

August 5 - 10, 2007
Chairs Michael S. Roberts and Anthony V. Rawlings
Vice Chairs Walter M. Holleran and Neil Kitson
Salve Regina University
100 Ochre Point Avenue
Newport, Rhode Island, United States
 Venue and Travel Information

Conference Description

The 10th Gordon Research Conference on Barrier Function of Mammalian Skin is scheduled to be held August 5-10, 2007 at Salve Regina University in Rhode Island. The Conference will seek to have an optimal mix of attendees from academics, industry and government, in seniority and in country. The 2007 conference proposes a balance of topics with individual sessions devoted to the Topics listed below. In addition, three poster sessions are scheduled for the evening with up to 30 presentations each, which will complement the diverse themes of the meeting.

The 2007 GRC meeting on Barrier Function of Mammalian Skin will be an important interdisciplinary venue, where the latest information and developments in this field will be shared. It will hopefully lead to immediate, practical consequences for patients with skin and other disorders as well as to new insights into the origin and maintenance of mammalian barrier function.

Conference Program

SUNDAY
2:00 pm - 11:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pm The adaptive and reactive barrier
Discussion Leader: Neil Kitson (UBC, Canada)
7:40 pm - 8:05 pmDaniel Maes (Estee Lauder, US)
"Body site, seasonal, psychological, gender & racial differences in barrier function"
8:05 pm - 8:12 pm Discussion
8:12 pm - 8:47 pmBrian Nickoloff (University Of Chicago Medical Center, USA)
"Cracking the Cytokine Code Contributing to Barrier Dysfunction in Psoriatic Plaques"
8:47 pm - 8:55 pm Discussion
8:55 pm - 9:20 pmMichael Cork (Children's Hospital, Sheffield, UK)
"Barrier functionality & repair - a clinical view"
9:20 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm Stratum corneum formation and maturation
Discussion Leader: Tony Rawlings (AVR Consulting Ltd, UK)
9:00 am - 9:30 amEleftherios Diamandis (Mount Sinai Hospital, Canada)
"Desquamation : Whats new?"
9:30 am - 9:40 am Discussion
9:40 am - 10:10 amMichel Simon (Faculté de Médecine, Toulouse Cedex, France)
"Peptidylarginine deiminase isoenzymes & function"
10:10 am - 10:15 am Discussion
10:15 am Coffee Break / Group Photo
10:50 am - 11:20 amErwin Tschachler (Medical University of Vienna, Austria)
"Differentiation or apoptosis?"
11:20 am - 11:30 am Discussion
11:30 am - 12:00 pmIrwin McClean (University of Dundee, United Kingdom)
"Functions of filaggrin & associated genes"
12:00 pm - 12:10 pm Discussion
12:10 pm - 12:20 pmHot Topic: Sheree Cross (University of Queensland, Australia)
"Skin surfactant Proteins"
12:20 pm - 12:30 pm Poster Talk: Carolyn Byrne (Queen Mary University of London)
"AKT signaling in skin barrier development and homeostasis"
12:30 pmLunch
1:30 pm - 6:00 pmFree Time
6:00 pmDinner
7:30 pm - 9:30 pm Strategies to maximise and assess skin penetration
Discussion Leader: Mike Roberts (University of Queensland, Australia)
7:30 pm - 8:00 pmAnnette Bunge (Colorado School of Mines, USA)
"Interplay of formulation thermodynamics, solute structure and the skin barrier"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:40 pmRichard Guy (University of Bath, UK)
"Assessment of topical drug delivery and bioavailability"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:20 pmRuss Potts (Russ Potts Consulting, USA)
"Getting our products to where it matters"
9:20 pm - 9:30 pm Discussion
9:30 pm - 11:00 pm Poster Session
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm Emerging epidermal barrier functions
Discussion Leader: Walt Holleran (VA Medical Centre, San Francisco, USA)
9:00 am - 9:30 amKen Feingold (VA Medical Centre, San Francisco, USA)
"The ABCs of Permeability Barrier Homeostasis"
9:30 am - 9:40 am Discussion
9:40 am - 10:10 amFaith Williams (Toxicology Unit, University of Newcastle, UK)
"Epidermal transporters and skin metabolism"
10:10 am - 10:20 am Discussion
10:20 am - 10:30 amHot Topic: Julia Caussin (Leiden/Amsterdam Center for Drug Research, The Netherlands)
"How moisturisers work on barrier function"
10:30 am Coffee Break
11:00 am - 11:30 amRichard Gallo (University of California, San Diego, USA.)
"Antimicrobial and other defense mechanisms"
11:30 am - 11:40 am Discussion
11:40 am - 12:10 pmDes Tobin (University of Bradford, UK)
"Sensing the environment"
12:10 pm - 12:20 pm Discussion
12:20 pm - 12:30 pm Poster Talk: Charles Roch-Philippe (University of Lausanne)
"The sodium channel ENaC is required for the post-natal maturation of the epidermal permeability barrier function"
12:30 pmLunch
1:30 pm - 6:00 pmFree Time
6:00 pmDinner
7:30 pm - 9:30 pm Skin biomechanics
Discussion Leader: Howard Maibach (UCSF, USA)
7:30 pm - 7:55pmBirgit Lane (Proteos, Singapore)
"Keratinocyte mechanics & keratin remodeling"
7:55 pm - 8:00 pm Discussion
8:00 pm - 8:25 pmReiner Dauskardt (Stanford University, USA)
"Stratum corneum biomechanics"
8:25 pm - 8:30 pm Discussion
8:30 pm - 8:55 pmMark Kendall (University of Queensland, Australia)
"Skin mechanical properties - what is needed to pierce the barrier?"
8:55 pm - 9:00 pm Discussion
9:00 pm - 9:25 pmHoward Maibach (UCSF, USA)
"What Bioengineering Does and Does Not offer!"
9:25 pm - 9:30 pm Discussion
9:30 pm - 11:00 pm Poster Session
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm Consequences of affecting or crossing the skin barrier
Discussion Leader: Bill Dressler (Huntingtown, USA)
9:00 am - 9:30 amChris Anderson (University of Linkoping, Sweden)
"Response, wound repair & clinical issues associated with breaching the barrier"
9:30 am - 9:40 am Discussion
9:40 am - 10:10 amNancy Monteiro-Riviere (NCSU, USA)
"Dermal effects of nanomaterials and other topical products"
10:10 am - 10:20 am Discussion
10:20 am - 10:30 amHot Topic: Guang Wei Lu (Pfizer, US)
"Sebum and Drug Penetration"
10:30 am Coffee Break
11:00 am - 11:30 amGerhard Nohynek (L’Oreal R&D, France)
"Minimizing the potential adverse effects of hairdyes, cosmetics and cosmeceuticals"
11:30 am - 11:40 am Discussion
11:40 am - 12:10 pmBob Bronaugh (FDA, USA)
"Regulatory issues, emphasizing modifying the SC reservoir and effects of nanoparticles"
12:10 pm - 12:20 pm Discussion
12:20 pm - 12:30 pm Poster Talk: Jyoti Gupta (Georgia Institute of Technology)
"Skin Barrier Recovery After Microneedle Treatment in Human Subjects"
12:30 pmLunch
1:30 pm - 6:00 pmFree Time
6:00 pmDinner
7:30 pm - 9:30 pm Keynote talk, Hot Topics & Young Investigators Session
Discussion Leaders: Steven Hoath (Cincinnati Children’s Hospital Medical Center, USA) and Jerry Kasting (University of Cincinnati College of Pharmacy, USA
7:30 pm - 8:15 pmKeynote Talk: Peter Elias (UCSF, USA)
"How Barrier Dysfunction Trumps Immunological Abnormalities in Atopic Dermatitis"
8:15 pm - 8:25 pm Discussion
8:25 pm - 8:35 pmHot Topic: Audra Stinchcomb (UK College of Pharmacy, USA)
"Prodrugs and codrugs as strategies to improve percutaneous absorption"
8:35 pm - 8:45 pm Mei Li (CERBM-GIE - I.G.B.M.C, CEDEX.)
"Keratinocytic nuclear receptors are involved in the pathogenesis of atopic dermatitis"
8:45 pm - 8:55 pm Johanna Brandner (University Hospital Hamburg-Eppendorf)
"Regulation of Epidermal Tight-Junctions (TJ) during Staphylococcal Skin Infections"
8:55 pm - 9:05 pm Hot Topic: Jim Riviere (NCSU, USA)
"Mixed solvents and skin permeability"
9:05 pm - 9:15 pm Discussion
9:15 pm - 9:30 pm Discussion: Jerry Kasting (University of Cincinatti, USA), Yuri Dancik and Owen Jepps (University of Queensland, Australia)
"Dermis transport"
9:30 pm - 11:00 pm Poster Session
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm Lifestyle and barrier function
Discussion Leader: Raman Govindarajan (Johnson & Johnson Asia Pacific, Singapore)
9:00 am - 9:30 amJens Thiele (Boston University, USA)
"Effects of antioxidants on the skin barrier"
9:30 am - 9:40 am Discussion
9:40 am - 10:10 amJohan Wiechers (Uniqema - The Netherlands)
"Cosmeceutical formulation strategies that deliver"
10:10 am - 10:20 am Discussion
10:20 am - 10:30 amHot Topic: Florence Puch (Danone Research, France)
"Improving SC water barrier function"
10:30 am Coffee Break
11:00 am - 11:30 amDominique Bernard (L'Oreal, France)
"Sensitive skin: a neurological perspective"
11:30 am - 11:40 am Discussion
11:40 am - 12:10 pmJuergen Lademann (Charité Hospital, Berlin, Germany)
"How to achieve effective targeting and response via sweat ducts and follicles"
12:10 pm - 12:20 pm Discussion
12:20 pm - 12:30 pm Poster Talk: Mikhail Kiselev (Joint Institute for Nuclear Research)
"Significance of the fully extended conformation of ceramide molecules in the nanostructure of stratum corneum"
12:30 pmLunch
1:30 pm - 6:00 pmFree Time
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
(Nominations for the next Vice Chair(s); Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair(s))
7:30 pm - 9:30 pm DEBATE - Do corneocytes leak?
Discussion Leader: Adrian Williams (University of Reading, UK)
Leader Pro Team: Ken Walters (An-eX, UK)
Leader Con Team: Joke Bouwstra (Leiden University, THE NETHERLANDS)
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Contributors

NATIONAL INSTITUTES OF HEALTH
JOHNSON & JOHNSON COMPANIES
COLGATE-PALMOLIVE COMPANY
PFIZER, INC.
BEIERSDORF AG
ESTEE LAUDER COMPANIES
PENTAPHARM LTD
TRANSFORM PHARMACEUTICALS
L'OREAL

Conference Links

Conference History
Additional Fee Info

Barrier Function of Mammalian Skin (GRS)
August 9 - 10, 2025
Epithelial Differentiation and Keratinization
June 1 - 6, 2025
Tissue Repair and Regeneration
June 1 - 6, 2025


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