SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff & Conference Chairs |
7:40 pm - 9:30 pm | MEMBRANE BIOPHYSICS & SKIN BIOMECHANICS |
| Discussion Leaders: Jenifer Thewalt (Simon Fraser University, Vancouver, Canada) and Juergen Lademan (Charite Hospital, Berlin, Germany) |
7:40 pm - 8:05 pm | Evan Evans (University of British Columbia, Vancouver)
"Membrane biophysics and the skin" |
8:05 pm - 8:20 pm | Discussion |
8:20 pm - 8:45 pm | Michel Lafleur (University of Montreal, Quebec)
"Organization and phase behavior of stratum corneum lipids" |
8:45 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Jamshed Anwar (University of Bradford, UK)
"Simulations of skin barrier function " |
9:20 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | BARRIER STRUCTURE AND FUNCTION: INSIGHTS FROM NOVEL TECHNOLOGIES & APPLICATIONS |
| Discussion Leaders: Reinhard Neubert (Martin Luther University, Halle, Germany) and Jerry Kasting (University of Cincinnati College of Pharmacy) |
9:00 am - 9:25 am | Luis A. Bagatolli (University of Southern Denmark, Odense, Denmark)
"Visualization of lipid domains in skin structure and transdermal delivery of liposomes" |
9:25 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Sunney Xie (Harvard University, Cambridge, MA)
"Skin imaging with Coherent Raman Spectroscopy (CARS)" |
10:05 am - 10:20 am | Discussion |
10:20 am | Coffee Break / Group Photo |
10:40 am - 11:05 am | Annett Schroeter (Martin Luther University, Halle, Germany)
"Role of ceramide [AP] for the structural assembly of stratum corneum lipids" |
11:05 am - 11:20 am | Discussion |
11:20 am - 11:45 am | Joke Bouwstra (Center for Biopharm. Sciences, Leiden University, The Netherlands)
"Novel insights in the skin barrier lipid organization" |
11:45 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Guy German (Yale University, New Haven, CT)
"Imaging stress in the stratum corneum during dehydration" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Jeroen van Smeden (Leiden University, The Netherlands)
"Development of a quick & robust detection method for skin ceramides" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session #1 |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | MOLECULAR REGULATION AND MATRIX SIGNALING IN EPIDERMAL BARRIER GENERATION |
| Discussion Leaders: Kenneth R. Feingold (University of California, San Francisco CA) and Theodora Mauro (University of California San Francisco) |
7:30 pm - 7:55 pm | Dennis Roop (University of Colorado, Aurora, CO)
"Molecular mechanisms regulating epithelial stratification" |
7:55 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Alan R. Brash (Vanderbilt University, Nashville, TN)
"Novel lipid mediators in barrier formation & function (12-R-Lipoxygenase products/hepoxilins)" |
8:35 pm - 8:50 pm | Discussion |
8:50 pm - 9:00 pm | Arup Indra (Oregon State University, Oregon)
"Dual role of COUP-TF-interacting protein 2 (CTIP2) in epidermal homeostasis and permeability barrier formation" |
9:00 pm - 9:05 pm | Discussion |
9:05 pm - 9:15 pm | Fang Liu (Wadsworth Center, NY)
"Genomic analysis of mouse phenocopies reveals distinct levels of control of keratinocyte terminal differentiation" |
9:15 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | MEMBRANE LIPIDS & TRAFFICKING IN BARRIER FORMATION & FUNCTION |
| Discussion Leaders: Lars Norlen (Karolinska Institut, Stockholm, Sweeden) and Phillip Wertz (University of Iowa, IA) |
9:00 am - 9:25 am | Gerrit van Meer (Utrecht University, The Netherlands)
"Membrane lipid transport, microdomains, and lamellar body formation" |
9:25 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Masashi Akiyama (Hokkaido University, Sapporo, Japan)
"ABCA12 in lamellar body formation and function" |
10:05 am - 10:20 am | Discussion |
10:20 am | Coffee Break |
10:40 am - 11:05 am | Akemi Ishida-Yamamoto (Asahikawa University, Japan)
"Lamellar body trafficking in the epidermal barrier and disease" |
11:05 am - 11:20 am | Discussion |
11:20 am - 11:45 am | Michel Simon (Toulouse, France)
"Trafficking and secretion of lamellar bodies: Lessons from proteomic characterization" |
11:45 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Sevgi Gungor (Istanbul University, Turkey)
"Transdermal flux predictions for highly lipophilic compounds: Comparison with experimental results" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Yoshikazu Uchida (University of California San Francisco)
"Ceramide metabolites in epidermal permeability barrier function and atopic dermatitis" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session #2 |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | SKIN BARRIER AS BIOSENSOR: NEURAL-EPIDERMAL CONNECTIONS |
| Discussion Leaders: Steven Hoath (Cincinnati Children's Hospital Medical Center) and Des Tobin (University of Bradford, UK) |
7:30 pm - 7:55 pm | Mitsuhiro Denda (Shiseido, Yokohama, Japan)
"Neuro-effectors of the epidermal barrier" |
7:55 pm - 8:10 pm | Discussion |
8:10 pm - 8:20 pm | Hyunjung Kim (Yonsei University, Seoul, Korea)
"Potential role of TRPV5 and 6 in the formation of epidermal calcium gradients and keratinocyte differentiation" |
8:20 pm - 8:25 pm | Discussion |
8:25 pm - 8:35 pm | Truus Roelandt (Ziekenhuis University Brussels, Belgium)
"Cannabinoid receptors 1 and 2 regulate epidermal barrier status" |
8:35 pm - 8:40 pm | Discussion |
8:40 pm - 8:55 pm | Tarl Prow (University of Queensland, Australia)
"Nanoparticle-biological interactions in the skin" |
8:55 pm - 9:05 pm | Discussion |
9:05 pm - 9:20 pm | Ken Feingold (University of California, San Francisco)
"Cytokines in fetal barrier development" |
9:20 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | CROSSING EPIDERMIS & OTHER BARRIERS: LESSONS FROM LUNG, GI, & BRAIN BARRIERS |
| Discussion Leaders: Nancy Monteiro-Riviere (North Carolina State Univ., Raleigh NC) and Annette Bunge (Colorado School of Mines, Golden, CO) |
9:00 am - 9:25 am | Jesus Perez-Gil (Universidad Complutense, Madrid, Spain)
"2D & 3D membrane (net)works at the borderline: Pulmonary surfactant" |
9:25 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Eduard Stange (Robert Bosch Hospital, Stuttgart, Germany)
"Antimicrobial peptides in the maintenance of mucosal barrier & Crohn's Disease" |
10:05 am - 10:20 am | Discussion |
10:20 am | Coffee Break |
10:40 am - 11:05 am | Nadine Barrie Smith (Pennsylvania State University, Hershey, PA)
"Delivery of nanoliposomal siRNA targeted against cutaneous melanoma" |
11:05 am - 11:20 am | Discussion |
11:20 am - 11:45 am | Samir Mitragotri (University of California, Santa Barbara, CA)
"Enhancement of drug delivery through GI mucosal epithelia & the stratum corneum" |
11:45 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Omathanu Perumal (South Dakota State University, Brookings)
"Transcutaneous inontophoretic delivery of antisense oligonucleotides using nanocarriers" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Luke Mortensen (University of Rochester, NY)
"Effects of UVR on in vivo skin penetration and in vitro skin cell uptake of quantum dot nanoparticles" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session #3 |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | EMERGING BARRIER FUNCTIONS & TECHNOLOGIES: HOT TOPICS & YOUNG INVESTIGATORS |
| Discussion Leaders: Kevin Mills (Procter & Gamble, Cincinnati OH) and Mike Roberts (University of Queensland, Australia) |
7:30 pm - 7:40 pm | Arne Naegel (Goethe University, Frankfurt, Germany)
"Comparison of numerical simulations of two-dimensional, biphasic stratum corneum membranes with impermeable and permeable corneocytes" |
7:40 pm - 7:50 pm | Discussion |
7:50 pm - 8:00 pm | Lei Zhang (University of Colorado at Denver)
"A novel ABCA12 mutant mouse model provides new insight into the pathological mechanisms of Harlequin Ichthyosis" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:20 pm | Simona Frateschi (University of Lausanne, Switzerland)
"Dysregulation of channel activating protease 1 in mouse epidermis" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:40 pm | Takuo Yuki (Kanebo Basic Research Lab, Odawara, Japan)
"Activation of Toll-like receptor-2 enhances the intercellular permeability barrier of tight junctions in normal human keratinocytes" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:00 pm | Liselotte Jensen (University of Pennsylvania)
"Toll-like receptor-2 and interleukin-1 signaling in keratinocytes during Staphlococcus aureus infections" |
9:00 pm - 9:10 pm | Discussion |
9:10 pm - 9:20 pm | Kazutami Sakamoto (Tokyo University of Science, Tokyo, Japan)
"Peptide penetration of skin: Curvature vs. penetration. ESR/EPR of skin lipids; arginine aa-penetration" |
9:20 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | STRATUM CORNEUM STRUCTURE, FUNCTION, & DISEASE |
| Discussion Leaders: Peter M. Elias (University of California San Francisco, CA) and Seung Hun Lee (Yonsei University, Seoul, Korea) |
9:00 am - 9:25 am | Jens M. Schroeder (Kiel University, Germany)
"Antimicrobial peptides in innate immunity barriers" |
9:25 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Alain Hovnanian (INSERM, Paris, France)
"Serine protease regulation in stratum corneum function and disease" |
10:05 am - 10:20 am | Discussion |
10:20 am | Coffee Break |
10:40 am - 11:05 am | Edith Hummler (University of Lausanne, Switzerland)
"The epithelial sodium channel (ENaC) in epidermal barrier function" |
11:05 am - 11:20 am | Discussion |
11:20 am - 11:45 am | Lilly Bourguignon (University of California San Francisco)
"Matrix (hyaluronan) signaling in epidermal formation and repair" |
11:45 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Yutaka Takagi (Kao Biological Sciences, Japan)
"Relationship between ceramide profile and cutaneous barrier function" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Padraic Fallon (Trinity College, Dublin, Ireland)
"A homozygous frameshift mutation in the mouse Flg gene facilitates enhanced percutaneous allergen priming" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 6:00 pm | Free Time |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | DEBATE & DISCUSSION: MATH OVER MOUSE - INSIGHTS FROM ALTERNATE PERSPECTIVES |
| Discussion Leader & Moderator: Keith Brain (Cardiff, United Kingdom) |
7:30 pm - 8:10 pm | Richard Guy (University of Bath, United Kingdom)
"Pro Team" |
8:10 pm - 8:30 pm | Discussion |
8:30 pm - 9:10 pm | Jim Riviere (North Carolina State University, Raleigh, NC)
"Con Team" |
9:10 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |