Sunday |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Keynote Session: Progress in Defining, Investigating and
Surmounting the Barrier |
| Discussion Leaders: Theodora Mauro (University of California, San Francisco, USA) and Philip Wertz (University of Iowa, USA) |
7:40 pm - 8:05 pm | Peter Elias (Veterans Administration Medical Center / University of California, San Francisco, USA) "The Impact of Pigmentation on Barrier Function" |
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:40 pm | Richard Guy (University of Bath, United Kingdom) "Imaging Drug Delivery to Skin and Nail with Micro(spectro)scopic Techniques" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | Lars Norlen (Karolinska Institute, Sweden) "Molecular Organization of Skin
Barrier Formation" |
9:15 pm - 9:30 pm | Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Normal and Pathological
Responses to Barrier Disruption |
| Discussion Leaders: Steven Hoath (University of Cincinnati, USA) and Birgit Lane (Institute of Medical Biology, Singapore) |
9:00 am - 9:30 am | Allan Balmain (University of California, San Francisco, USA) "Genetic Control of Skin Barrier Function, Inflammation and
Carcinogenesis" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Fiona Watt (Kings College London, United Kingdom) "How
Differentiated Epidermal Cells Influence Cancer Susceptibility" |
10:15 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Group Photo / Coffee Break |
11:00 am - 11:30 am | Frank Nestle (King's College London, United Kingdom) "Factors Influencing the Balance Between Skin Immune
Homeostasis and Pathology" |
11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | Maria Morasso (National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, USA) "Contribution of Keratinocyte Dysfunction to Cutaneous Inflammation" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Overcoming
the Barrier in Delivering Therapeutics |
| Discussion Leader: Gerald Kasting (University of Cincinnati, USA) |
7:30 pm - 7:50 pm | Adrian Davis (Limeway Pharma Design Ltd., United Kingdom) "Improved Patient Adherence by Taking
Back Control from the Skin
Barriers" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Amy Paller (Northwestern University, USA) "Nanoconstructs as Topical Gene Therapy for Skin Disease" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Samir Mitragotri (University of California, Santa Barbara, USA) "Ionic Liquids for Transdermal and Topical Drug
Delivery" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Majella Lane (University College London, United Kingdom) "New Adventures in the Skin Trade" |
9:20 pm - 9:30 pm | Discussion |
Tuesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Regulating
Barrier Formation and Maintenance |
| Discussion Leader: Nava Dayan (Dr. Nava Dayan, LLC, USA) |
9:00 am - 9:30 am | Masayuki Amagai (Keio University School of Medicine, Japan) "Dissecting
Skin Barrier Dysfunction as a Cause of Dermatitis" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Thomas Magin (University of Leipzig, Germany) "Keratins as Integrators of Cornified Envelope Regulation
and Function" |
10:15 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:30 am | Carien Niessen (University of Cologne, Germany) "Metabolic
Regulation of Skin Barrier Formation and Function" |
11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | Sabine Werner (ETH Zurich, Switzerland) "Cytoprotective Signaling Pathways in the Control
of Barrier Function" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | New
Technology for Investigating / Penetrating the Barrier |
| Discussion Leaders: Marek Haftek (University of Lyon / CNRS, France) and Michael Roberts (University of South Australia / University of Queensland, Australia) |
7:30 pm - 7:50 pm | Roger Kaspar (TransDerm, USA) "Overcoming the Barrier – Development of Delivery Technologies for Potential Pachyonychia Congenita Therapeutics" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Kevin Mills (Procter and Gamble Company, USA) "Molecular Profiling in Health
and Disease: Utility in Discovery of Agents to Improve Skin Condition" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Xiao-Jing Wang (University of Colorado, Denver, USA) "Smad7-Based Therapeutics for Chronic Wound Healing" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Gabriel Wittum (Goethe Center for Scientific Computing, Goethe University Frankfurt, Germany) "In Silico Modeling the Barrier Function of Human Skin" |
9:20 pm - 9:30 pm | Discussion |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Itch
and the Epidermal Barrier |
| Discussion Leader: Cristina De Guzman Strong (Washington University School of Medicine, USA) |
9:00 am - 9:30 am | Ethan Lerner (Harvard University School of Medicine, USA) "Understanding Itch: Are We There
Yet?" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Sarah Ross (University of Pittsburgh, USA) "The Neural Basis for Itch and Its Inhibition by Counter
Stimuli" |
10:15 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:30 am | Giuseppe Lauria (Foundation I.R.C.C.S., Institute of Neurology, Milano, Italy) "The Skin as a Nociceptor" |
11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | Heidi Kong (National Cancer Institute, NIH, USA) "Studying Microbiota in Atopic Dermatitis: The Itch That Rashes" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | Late-Breaking Topics / Young Investigator Presentations |
| This session will have eight presentations (10 minutes duration, 5 minute discussion) to be selected from the abstracts received. |
| Discussion Leaders: Joachim Fluhr (Charité - Universitätsmedizin Berlin, Germany) and Reinhard H. Neubert (Martin Luther University Halle-Wittenberg, Germany) |
7:30 pm - 7:40 pm | Hongzhen Hu (Washington University in St. Louis, USA) "Activation of TRPV4-Expressing Resident Cells in the Skin Promotes Itch" |
7:40 pm - 7:45 pm | Discussion |
7:45 pm - 7:55 pm | Mary Bedard (Stiefel, a GSK Company, USA) "An Ex Vivo Skin Model that Combines Topical Skin Penetration and Th17 Stimulation" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:10 pm | Stefan Hoenzke (Freie Universitat Berlin, Germany) "Filaggrin Deficiency Alters the Innate Immune Response in a 3D Skin Model" |
8:10 pm - 8:15 pm | Discussion |
8:15 pm - 8:25 pm | Yosuke Ishitsuka (Charles C. Gates Center for Regenerative Medicine and Stem Cell Biology, University of Colorado, USA) "The Nrf2/Keap1 Pathway Contributes to the Pathogenesis of Atopic Dermatitis by Directly Regulating the IL33/ST2 Pathway in the Epidermis" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:40 pm | Hanne Engelsby (University of Southern Denmark, Denmark) "Loss of Acyl-CoA Binding Protein in Mice Results in Decreased Levels of Protein Bound Ceramides in Stratum Corneum and Affects Epidermis Integrity" |
8:40 pm - 8:45 pm | Discussion |
8:45 pm - 8:55 pm | Adina Eichner (Martin Luther Universtity Halle Wittenberg, Germany) "New Insights into the Structure-Function Relationship of Long-Chain Omega-Acyl Ceramides to the Nanostructure of Stratum Corneum Lipid Model Membranes" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Magdalena Hoppel (University of Vienna, Austria) "Self-Assembled Nanostructured Aqueous Dispersions as Dermal Delivery Systems" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Ulrike Alexiev (Freie Universität Berlin, Germany) "A New Fluorescence Lifetime Imaging Microscopy Technique Reveals Skin Penetration and Differential Cellular Uptake of Tecto-Dendrimer Nanoparticles in Human Reconstructed Skin Models" |
9:25 pm - 9:30 pm | Discussion |
Thursday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Stratum Corneum
Structure and Function: What Is New? |
| Discussion Leaders: Joke Bouwstra (Leiden Academic Centre for Drug Research (LACDR), The Netherlands) and Juergen Lademann (Charité - Universitätsmedizin Berlin, Germany) |
9:00 am - 9:25 am | Alain Hovnanian (INSERM UMR1163, Imagine Institute, France) "Protease-Mediated
Signaling Cascades and Their Regulation in the Skin" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Daniel Huster (University of Leipzig, Germany) "Investigation of the Structure
and Phase Bahavior of Stratum
Corneum Models by Solid-State
NMR Spectroscopy" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:35 am | Matthew Hardman (University of Manchester, United Kingdom) "The Host-Microbiota Axis in Skin Wound Repair" |
10:35 am - 10:45 am | Discussion |
10:45 am - 11:15 am | Coffee Break |
11:15 am - 11:40 am | Andrzej Slominski (University of Alabama at Birmingham, USA) "Cutaneous Melatoninergic and Secosteroidogenic Systems as Protectors of Epidermal Integrity" |
11:40 am - 11:55 am | Discussion |
11:55 am - 12:20 pm | Gerald Brezesinski (Max Planck Institute, Potsdam-Golm, Germany) "Interaction of Ceramides and Their Mixtures with Penetration
Enhancers: A Monolayer Approach" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Skin Barrier in Health and Disease / In Vitro vs. In Vivo Models of Barrier Function |
| Discussion Leaders: Walter Holleran (Veterans Administration Medical Center / University of California, San Francisco, USA) and Gopinathan Menon (ASI Corporation, USA) |
7:30 pm - 7:55 pm | Arup Indra (Oregon State University / Oregon Health and Science University, USA) "Epidermal Lipids in Barrier Integrity: From Animal Models to Humans" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Jerrold Turner (The University of Chicago, USA) "Tight Junctions in Regulation of Epithelial
Barrier and Pathogenesis of Crohn's Disease" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:05 pm | Spiro Getsios (Northwestern University, USA) "Perspectives
on a Top-Down Approach" |
9:05 pm - 9:15 pm | Discussion |
9:15 pm - 9:30 pm | General Discussion |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |