Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: New Developments in Skin and Epidermal Equivalent Models
Discussion Leader: Maria Morasso (National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, USA)
7:40 pm - 8:20 pm
Ellen Van Den Bogaard (Radboud University Medical Center, The Netherlands)
"Alternatives for Primary Keratinocytes in Experimental Dermatological Research"
8:20 pm - 8:35 pm
Discussion
8:35 pm - 9:15 pm
Michel Salmon (StratiCELL, Belgium)
"Complexification of In Vitro 3D Skin Models: Sensory Aspects and Atopic Skin"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Insights into Barrier Function from Human Epidermal Pathology
Discussion Leaders: Matthias Schmuth (Medical University of Innsbruck, Austria) and Nicole Brogden (University of Iowa, USA)
9:00 am - 9:30 am
Sandrine Dubrac (Medical University of Innsbruck, Austria)
"Eicosanoid Metabolism in FLG-Mutated Atopic Dermatitis"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
Anna De Benedetto (University of Florida, USA)
"Epidermal Barrier in Atopic Dermatisis: Role of PAR-2 and Tight Junctions"
10:05 am - 10:10 am
Discussion
10:10 am - 10:35 am
Group Photo / Coffee Break
10:35 am - 11:05 am
Nathalie Jonca (UMR 1056, INSERM / University of Toulouse, France)
"Role of PNPLA1 in CLE and Barrier Elaboration"
11:05 am - 11:15 am
Discussion
11:15 am - 11:45 am
Akemi Ishida-Yamamoto (Asahikawa Medical University, Japan)
"Molecular Basis of the Skin Barrier Structures Revealed by Electron Microscopy in Health and Disease"
11:45 am - 11:55 am
Discussion
11:55 am - 12:20 pm
Katerina Vavrova (Charles University, Faculty of Pharmacy, Czech Republic)
"Ultra-Long Ceramides in the Skin Barrier"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizer: Ellen Van Den Bogaard (Radboud University Medical Center, The Netherlands)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
In Silico Modeling of the Barrier and Permeation Pathways
Discussion Leader: Olga Lopez (Institute for Advanced Chemistry of Catalonia, Spanish National Research Council, Spain)
7:30 pm - 8:00 pm
Clare McCabe (Vanderbilt University, USA)
"Molecular Dynamics Simulations of Stratum Corneum Lipid Mixtures: A Multiscale Perspective"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Rebecca Notman (University of Warwick, United Kingdom)
"Modeling Permeation Through Skin Lipids"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Reiko Tanaka (Imperial College London, United Kingdom)
"Modeling Barrier Homeostaisis Regulatory Processes "
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Spontaneous and Man-Made Animal Models of the Epidermal Barrier Dysfunction
Discussion Leader: Gopinathan Menon (California Academy of Sciences, USA)
9:00 am - 9:30 am
Wim Declercq (VIB, Ghent University, Belgium)
"RIPK4, an Important Player in Skin Homeostasis"
9:30 am - 9:45 am
Discussion
9:45 am - 10:20 am
Elizabeth Mauldin (University of Pennsylvania, USA)
"Cellular and Metabolic Basis for the Ichthyotic Phenotype in NIPAL4 (Ichthyin)-Deficient Canines"
10:20 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:35 am
Wolfgang Bäumer (Free University of Berlin, Germany)
"Translational Animal Models of Atopic Dermatitis for Preclinical Studies"
11:35 am - 11:50 am
Discussion
11:50 am - 12:20 pm
Mitsuhiro Denda (Shiseido Global Innovation Center, Japan)
"In Silico Predictive Model Provides Rational Basis for Establishing 3-D Epidermal Equivalent Systems"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Predicting, Measuring and Modeling Topical Drug Delivery
Discussion Leader: Samir Mitragotri (Harvard University, USA)
7:30 pm - 8:00 pm
Aneesh Alex (GlaxoSmithKline, USA)
"Imaging Biodistribution of Topical Drugs In Situ Using Multimodal Optical Microscopy"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Leandro Santos (Incyte Corporation, USA)
"Analytical and Predictive Tools for Topical Delivery: From NCE Selection to Clinical-Ready Formulation"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Emma Sparr (Lund University, Sweden)
"Tracking Solvents in the Skin Through Atomically Resolved Measurements of Molecular Mobility in Intact Stratum Corneum"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Regulation of Epidermal Barrier Constitution and Function
Discussion Leaders: Michel Simon (INSERM, France) and Arup Indra (Oregon Health and Science University, USA)
9:00 am - 9:30 am
Kwesi Teye (Kurume University, Japan)
"Unusual CD44 Form in Epidermal Differentiation"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Markus Kretz (University of Regensburg, Germany)
"Long Noncoding RNAs in Skin Homeostasis and Disease"
10:10 am - 10:25 am
Discussion
10:25 am - 10:50 am
Coffee Break
10:50 am - 11:25 am
Andor Pivarcsi (Karolinska Institutet, Sweden)
"Micro-RNA in Skin Homeostasis and Aging"
11:25 am - 11:40 am
Discussion
11:40 am - 12:15 pm
Desmond Tobin (University College Dublin, Ireland)
"Pigmentation and Melanin in Skin Barrier Function"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Late-Breaking Topics / Selected Poster Presentations
Discussion Leaders: M. Begona Delgado-Charro (University of Bath, United Kingdom) and Marjana Tomic-Canic (Miller School of Medicine, University of Miami, USA)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:45 pm
Anna Celli (University of California, San Francisco, USA)
"The Calcium Sensing Receptor Regulates Epidermal Intracellular Ca2+ Signaling and Re-Epithelialization in Aged Epidermis"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:00 pm
Benjamin Kuzma (Long Island University, USA)
"Estimation of In Vivo Percutaneous Permeation (Flux) and Cumulative Amount Input of Metronidazole Formulations in Minipigs' Dermis"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:15 pm
Zachary Lipsky (Binghamton University, USA)
"Lipid Reductions Enable Permeation of Staphylococcus aureus Bacteria Through Human Stratum Corneum"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:30 pm
Byeong Deog Park (SphingoBrain, USA)
"The Skin Is the Mirror of the Brain, Can the Skin Be the Biomarker of Autism?"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:45 pm
Sagar Shukla (University of Maryland, USA)
"Impact of Operator Variability on the Reproducibility of Tape Stripping Results"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:00 pm
Zhengxi Wei (National Center for Advancing Translational Sciences, NIH, USA)
"Integrated In Vitro Assays to Screen Potential Dermal Toxicants in the Tox21 10K Library"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:15 pm
Takeshi Yoshida (University of Rochester Medical Center, USA)
"Nonlesional Atopic Dermatitis Skin Shows Alterations in Langerhans Cells in Close Proximity to Tight Junction Fragmentation"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
New Insights into Stratum Corneum Lipid Composition, Organization and Dynamics
Discussion Leaders: Joke Bouwstra (Leiden Academic Centre for Drug Research (LACDR), Leiden University, The Netherlands) and Pankaj Karande (Rensselaer Polytechnic Institute, USA)
9:00 am - 9:30 am
Corinne Leprince (INSERM U1056, France)
"Rab11 and Actin-Based Myosin 5b Motor Are Crucial for Lamellar Body Trafficking in the Epidermis"
9:30 am - 9:45 am
Discussion
9:45 am - 10:20 am
Charlotte Beddoes (Leiden University, The Netherlands)
"Biophysical Studies of Barrier Lipids: From Complex to Simple Models"
10:20 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:35 am
Roger Sandhoff (German Cancer Research Center, Germany)
"Skin Barrier Ceramide Metabolism in Health and Disease"
11:35 am - 11:50 am
Discussion
11:50 am - 12:20 pm
Olga Lopez (Institute for Advanced Chemistry of Catalonia, Spanish National Research Council, Spain)
"Assessment of Skin Treatment with a Lamellar Body Mimicking Lipid System"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Changes in Epidermal Barrier Function in Health and Associated with Systemic Disease
Discussion Leader: Theodora Mauro (University of California, San Francisco, USA)
5:30 pm - 6:00 pm
Emer Duffy (Dublin City University, Ireland)
"Sniffing the Barrier: Probing Skin Function Through the Volatile Footprint"
6:00 pm - 6:10 pm
Discussion
6:10 pm - 6:40 pm
Sanja Kezic (Amsterdam University Medical Centre, The Netherlands)
"Stratum Corneum Biomarkers: A Non-Invasive Tool in Clinical Practice"
6:40 pm - 6:50 pm
Discussion
6:50 pm - 7:20 pm
Andrzej Slominski (University of Alabama at Birmingham, USA)
"Novel Pathways of Vitamin D and Lumisterol Activation and Their Role in the Epidermis Functions"
7:20 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure