Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: The Effects of Aging and Environment on the Skin Barrier
Discussion Leaders: Theodora Mauro (University of California, San Francisco, United States) and Amanda Williamson (Boston University, United States)
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:15 pm
Anna Celli (University of California, San Francisco, United States)
"Calcium Signaling in Ageing Epidermis"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Elena Goleva (National Jewish Health, United States)
"Multi-omic Aproaches to Characterize Skin Barrier Function: Implementations for the Skin Inflammation and Environmental Exposures"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
Elizabeth Kovacs (University of Colorado Denver, United States)
"Burns are More than Skin Deep: Inflamm-Aging and the Gut - Lung Axis"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Skin Colonizers: Making or Breaking the Barrier
Discussion Leaders: Lindsay Kalan (McMaster University, Canada) and Jamie Burgess (University of Miami, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Elizabeth Grice (University of Pennsylvania, United States)
"Microbial Mechanisms of Skin Barrier Maintenance & Repair"
9:35 am - 9:40 am
Discussion
9:40 am - 10:05 am
Irena Pastar (University of Miami Miller School of Medicine, United States)
"Staphylococci and Cutaneous Disorders: the Good, the Bad and the Ugly"
10:05 am - 10:10 am
Discussion
10:10 am - 10:20 am
Nathan Balukoff (University of Miami Miller School of Medicine Dermatology, United States)
"Inflammatory Modulation Correlates with Clinical Scarless Tunnel Resolution after Novel Anti-biofilm Therapy for Hidradenitis Suppurativa Tunneling Wounds"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Group Photo / Coffee Break
11:00 am - 11:25 am
Yves Poumay (University of Namur, Belgium)
"Experimental Identification in Fungi and Keratinocytes of Factors Involved during Epidermal Infection."
11:25 am - 11:30 am
Discussion
11:30 am - 11:55 am
Stuart Jones (King's College London, United Kingdom)
"Understanding the Barrier Penetration and Activity of Anti-Infective Gases"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Aayushi Uberoi (University of Pennsylvania, United States)
"Commensal Microbes Fortify Skin Barrier through the Control of Tryptophan-Aryl Hydrocarbon Receptor Cascade"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Elizabeth Grice (University of Pennsylvania, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Inflammation in Barrier Function and Dysfunction
Discussion Leaders: Katherine Gallagher (University of Michigan, United States) and Aayushi Uberoi (University of Pennsylvania, United States)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
Shruti Naik (NYU School of Medicine, United States)
"Adaptive and Maladaptive Immune-Epithelial Interactions"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Luisa DiPietro (University of Illinois Chicago, United States)
"Cellular Cross-Talk in Epithelial Repair"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Maria Morasso (National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, United States)
"Networks Regulating Tissue Repair and Inflammation: Lessons Learned from Comparative Models of Oral and Skin Wound Healing"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:05 pm
Rebecca Barresi (L'Oreal USA, United States)
"Human Ex Vivo Inflammatory Dermatosis Model Demonstrates Altered Epidermal Barrier Lipidome"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
Xiangmei Hua (University of Wisconsin-Madison, United States)
"Epidermal RORa Deficiency Causes Impaired Skin Barrier Functions and Enhanced Allergic Inflammatory Reactions."
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Optimizing Dermatological Therapies
Discussion Leaders: David Moore (University of Edinburgh, United Kingdom) and Priyanka Ghosh (FDA, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Rosalind Hannen (Keratify, Ltd./Queen Mary University London, United Kingdom)
"Overcoming Challenges in Skin Permeation and Toxicology Studies With New Fluidic Engineering"
9:35 am - 9:40 am
Discussion
9:40 am - 10:05 am
Jon Lenn (MedPharm, United States)
"Avoid the ‘Valley of Death’ - Topical Formulation Development for the Clinic"
10:05 am - 10:10 am
Discussion
10:10 am - 10:20 am
Abe Janis (Hollister Incorporated, United States)
"Establishing an Ex Vivo Model of Peristomal Skin Damage towards Developing Novel Ostomy Adhesives"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
Audra Stinchcomb (University of Maryland, Baltimore, United States)
"Advanced Harmonization Techniques Result in Accurate Establishment of In Vitro-In Vivo Relationships for Drug Permeation from Complex Dermal Formulations"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
Dusko Ilic (King's College London, United Kingdom)
"NETSKINMODELS - European Network for Skin Engineering and Modelling"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Noèlia Loza Rodríguez (IQAC-CSIC, Spain)
"Lipid Gel Systems for Skin Permeation and Ascorbic Acid Stabilization"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Shubham Pallod (Arizona State University, United States)
"Silk Fibroin-Based Materials for Skin Repair, Wound Healing, and Infection Control"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Big Data to Knowledge: Models, Diagnostics and Therapies
Discussion Leaders: Andor Pivarcsi (Uppsala University, Sweden) and Elena Goleva (National Jewish Health, United States)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
Cristina de Guzman Strong (Henry Ford Health/Michigan State University, United States)
"Using Multi-Omics to Understand Human Skin Barrier Evolution and Health Disparity"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Tesfaye Mersha (Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, United States)
"Leveraging Multilayered Omics Data for Atopic Dermatitis: A Road Map to Precision Medicine"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Florian Gruber (Medical University of Vienna /CDL SKINMAGINE, Austria)
"CDL-SKINMAGINE- a Multimodal Analytical Imaging Approach to Investigate the Epilipidome and Metabolic Adapations in Skin Stress and -Aging"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:05 pm
Tao Chen (University of Surrey, United Kingdom)
"Modelling Skin Penetration: Towards Computer-Aided Design of Topical Delivery and Safety Assessment"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
Jannik Rousel (Centre for Human Drug Research, The Netherlands)
"Impaired Barrier Function and Altered Stratum Corneum Ceramide Composition Characterizes Lesional Skin of Seborrheic Dermatitis; Results From a Cross-Sectional Observational Multimodal Study"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Predicting Permeation Through the Skin Barrier: Chemical Exposure and Risk Assessment
Discussion Leaders: Annette Bunge (Colorado School of MInes, United States) and Gerald Kasting (University of Cincinnati, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
John Troutman (Procter & Gamble, United States)
"Addressing Knowledge Gaps in Mechanistic Dermal Absorption Modeling through New Data Generation and Iterative Learning"
9:35 am - 9:40 am
Discussion
9:40 am - 10:05 am
James Clarke (Certara UK, United Kingdom)
"Applications of Physiologically Based Pharmacokinetic Modelling for Dermal Exposure Assessment"
10:05 am - 10:10 am
Discussion
10:10 am - 10:20 am
Manfred Bodenlenz (JOANNEUM RESEARCH GmbH, HEALTH – Institute for Biomedical Research and Technologies, Graz, Austria, Austria)
"Dermal Open-Flow Microperfusion Indicates Differences in Topical Drug Permeation Between Males and Females"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
Peter Olmsted (Georgetown University, United States)
"What Can Multi-Scale Modeling Tell Us about Permeation through the Stratum Corneum?"
11:25 am - 11:30 am
Discussion
11:30 am - 11:55 am
John Kissel (University of Washington (Retired), United States)
"Regulatory Strategies and Dermal Permeation Science"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Alec Salminen (U.S. Food and Drug Administration, United States)
"A Standardized Approach to Determine the Suitability of Alternative Skin Barrier Models for Use in Dermal Absorption Studies"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Applied Knowledge of Skin Barrier: From Discovery to Recovery
Discussion Leaders: Anna De Benedetto (University of Rochester Medical Center, United States) and Leandro Santos (Incyte Corporation, United States)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
Marianne Lind (LEO Pharma, Denmark)
"Design of Topical Formulations for Skin Diseases"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Chandan Sen (University of Pittsburgh, United States)
"Skin Barrier Function and Functional Wound Closure"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Andrew Liu (University Of Pittsburgh, United States)
"Neuroimmune Circuits Linking Scratching and Inflammation"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:05 pm
Tomas Andriuskevicius (Imperial College London, United Kingdom)
"Characterising Monoamine Signalling in Human Dermal Fibroblasts and Keratinocytes"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
Shinobu Nakanishi (Shiseido, Japan)
"Odorant Binding Protein 2A (OBP2A) Regulates Epidermal Barrier Function Against Small Hydrophobic Molecules and Epidermal Homeostasis: Possible Association with Atopic Dermatitis"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Imaging the Skin Barrier: Seeing the Previously Unseen
Discussion Leaders: Richard Guy (University of Bath, United Kingdom) and Mila Boncheva Bettex (Haleon, Switzerland)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:40 am
Sebastien Gregoire (L'Oréal R&I, France)
"Skin Mass Spectromery Imaging"
9:40 am - 9:45 am
Discussion
9:45 am - 10:15 am
Conor Evans (Massachusetts General Hospital / Harvard Medical School, United States)
"Pharmacokinetic and Pharmacodynamic Tomography: Imaging and Quantifying Skin Pharmacology"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:00 am
Yousuf Hussain MOHAMMED (University of Queensland, Australia)
"Micro Projection Array (MAP) Topography and Coating Efficiency"
11:00 am - 11:05 am
Discussion
11:05 am - 11:15 am
Valeria Cota (University of Iowa, United States)
"Optical Coherence Tomography as a Tool to Visualize Micropore Closure in Diverse Skin Types"
11:15 am - 11:25 am
Discussion
11:25 am - 11:55 am
Natalie Belsey (National Physical Laboratory, United Kingdom)
"Visualization of Topical Drug Delivery with Label-Free Chemical Imaging"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Vince Gruber (Vantage Personal Care, United States)
"ATP Biofluorescence as a Rapid Means to Quantify Probiotics Delivered from Topical Probiotic Treatments"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
The "Next Big Question” on the Skin Barrier
Discussion Leaders: Pankaj Karande (Rensselaer Polytechnic Institute, United States) and Nicole Brogden (University of Iowa, United States)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
Amanda MacLeod (Janssen R&D, United States)
"Future Outlook of Skin Barrier Science: Perspectives from Academia and Industry"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
Joke Bouwstra (Leiden Academic Centre for Drug Research (LACDR), Leiden University, The Netherlands)
"Do We Need Lipids for Skin Barrier Repair?"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:10 pm
Theodora Mauro (University of California, San Francisco, United States)
"Skin Barrier as a Complex Systems Biology"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure